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HDAC2 HDAC2 NOTCH1 NOTCH1 INTU INTU TBX3 TBX3 ENSMFAP00000043974 ENSMFAP00000043974 MSX1 MSX1 OSR1 OSR1 BCL2L11 BCL2L11 GNA12 GNA12 HAND2 HAND2 SFRP2 SFRP2 TBC1D32 TBC1D32 IFT140 IFT140 CPLANE1 CPLANE1 CREBBP CREBBP IMPAD1 IMPAD1 WNT5A WNT5A LRP4 LRP4 SALL1 SALL1 SMAD4 SMAD4 SHH SHH WNT7A WNT7A IFT52 IFT52 HOXA11 HOXA11 ENSMFAP00000025317 ENSMFAP00000025317 ENSMFAP00000024251 ENSMFAP00000024251 ECE1 ECE1 WDPCP WDPCP BAX BAX HOXD13 HOXD13 TMEM107 TMEM107 GRHL2 GRHL2 FLVCR1 FLVCR1 LMBR1 LMBR1 HOXD12 HOXD12 GLI3 GLI3 OSR2 OSR2 C2CD3 C2CD3 NOG NOG ZBTB16 ZBTB16 ENSMFAP00000010148 ENSMFAP00000010148 HDAC1 HDAC1 MAP3K20 MAP3K20 FZD6 FZD6 ENSMFAP00000008086 ENSMFAP00000008086 BMP4 BMP4 CTNNB1 CTNNB1 BMPR1A BMPR1A FREM2 FREM2 MKS1 MKS1 ALX4 ALX4 IHH IHH TBX2 TBX2 HOXC11 HOXC11 B9D1 B9D1 TULP3 TULP3 CHST11 CHST11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NOTCH1Notch receptor 1. (2556 aa)
INTUInturned planar cell polarity protein. (942 aa)
TBX3T-box transcription factor 3. (743 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
MSX1Msh homeobox 1. (303 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
GNA12G protein subunit alpha 12. (381 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
TBC1D32TBC1 domain family member 32. (1319 aa)
IFT140Intraflagellar transport 140. (1475 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3200 aa)
CREBBPCREB binding protein. (2442 aa)
IMPAD1Inositol monophosphatase domain containing 1. (313 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
LRP4LDL receptor related protein 4. (1913 aa)
SALL1Spalt like transcription factor 1. (1323 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
IFT52Intraflagellar transport 52. (437 aa)
HOXA11Homeobox A11. (311 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
ENSMFAP00000024251Homeobox domain-containing protein. (143 aa)
ECE1Endothelin converting enzyme 1. (769 aa)
WDPCPWD repeat containing planar cell polarity effector. (731 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
HOXD13Homeobox D13. (321 aa)
TMEM107Transmembrane protein 107. (146 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (529 aa)
HOXD12Homeobox D12. (270 aa)
GLI3GLI family zinc finger 3. (1579 aa)
OSR2Odd-skipped related transciption factor 2. (402 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
ENSMFAP00000008086Uncharacterized protein. (466 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CTNNB1Catenin beta 1. (781 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FREM2FRAS1 related extracellular matrix 2. (3170 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
ALX4ALX homeobox 4. (409 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
TBX2T-box transcription factor 2. (639 aa)
HOXC11Homeobox C11. (304 aa)
B9D1B9 domain containing 1. (204 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (464 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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