STRINGSTRING
ENSMFAP00000005860 ENSMFAP00000005860 NUDT21 NUDT21 MIER3 MIER3 HDAC2 HDAC2 BRMS1 BRMS1 MEF2B MEF2B CCND1 CCND1 ENSMFAP00000000647 ENSMFAP00000000647 KPNA2 KPNA2 TBX2 TBX2 WDTC1 WDTC1 MYOCD MYOCD KAT2A KAT2A ENSMFAP00000001828 ENSMFAP00000001828 HDAC10 HDAC10 CDC20 CDC20 MAPK10 MAPK10 NR2E1 NR2E1 PRKN PRKN NCOR2 NCOR2 TOP2A TOP2A ENSMFAP00000005456 ENSMFAP00000005456 ENSMFAP00000005566 ENSMFAP00000005566 THAP7 THAP7 PARP1 PARP1 HDAC3 HDAC3 RAD9B RAD9B TFAP4 TFAP4 ENSMFAP00000007313 ENSMFAP00000007313 BCL3 BCL3 MIER2 MIER2 HDAC1 HDAC1 HOXA10 HOXA10 SFPQ SFPQ NR2C1 NR2C1 H1-5 H1-5 ENSMFAP00000010148 ENSMFAP00000010148 LOC102126330 LOC102126330 HDAC9 HDAC9 BEX4 BEX4 KCTD21 KCTD21 ENSMFAP00000012453 ENSMFAP00000012453 NRIP1 NRIP1 LOC102134827 LOC102134827 ENSMFAP00000013287 ENSMFAP00000013287 GCM1 GCM1 PKN2 PKN2 MEF2D MEF2D ENSMFAP00000015493 ENSMFAP00000015493 SUDS3 SUDS3 GLI3 GLI3 MTA1 MTA1 MAGEA11 MAGEA11 HNRNPD HNRNPD DDX20 DDX20 GMNN GMNN CAMTA2 CAMTA2 HEY2 HEY2 RARA RARA DHX36 DHX36 ENSMFAP00000018577 ENSMFAP00000018577 HIF1A HIF1A RELA RELA HDAC4 HDAC4 LOC102124602 LOC102124602 ENSMFAP00000021335 ENSMFAP00000021335 NACC2 NACC2 KAT2B KAT2B SATB2 SATB2 SRF SRF ENSMFAP00000022925 ENSMFAP00000022925 ANKRA2 ANKRA2 ENSMFAP00000024220 ENSMFAP00000024220 DACT1 DACT1 IKZF3 IKZF3 TAL1 TAL1 TOP2B TOP2B MIER1 MIER1 HDAC6 HDAC6 ENSMFAP00000025317 ENSMFAP00000025317 MAGEA12 MAGEA12 ENSMFAP00000026376 ENSMFAP00000026376 HIC1 HIC1 MEF2C MEF2C ENSMFAP00000027449 ENSMFAP00000027449 AKAP8L AKAP8L SP1 SP1 SMG5 SMG5 NKX3-1 NKX3-1 MTA2 MTA2 C10orf90 C10orf90 MEF2A MEF2A ZBTB7B ZBTB7B NIPBL NIPBL BHLHE41 BHLHE41 AKAP8 AKAP8 BCOR BCOR PHB PHB NACC1 NACC1 LEF1 LEF1 ENSMFAP00000033178 ENSMFAP00000033178 MAGEB5 MAGEB5 FOXP3 FOXP3 CHD4 CHD4 PHF6 PHF6 CBX5 CBX5 RFXANK RFXANK ANKRD1 ANKRD1 PKN1 PKN1 ZMYND15 ZMYND15 NCOR1 NCOR1 MTA3 MTA3 BRMS1L BRMS1L MAPK8 MAPK8 TP53 TP53 SP2 SP2 PRDM1 PRDM1 ENSMFAP00000039407 ENSMFAP00000039407 CEBPB CEBPB CRY1 CRY1 ENSMFAP00000040719 ENSMFAP00000040719 RAD9A RAD9A CIR1 CIR1 TCF21 TCF21 YWHAE YWHAE ENSMFAP00000042484 ENSMFAP00000042484 TRAF6 TRAF6 USF1 USF1 RBBP4 RBBP4 ENSMFAP00000043974 ENSMFAP00000043974 ENSMFAP00000044019 ENSMFAP00000044019 LCOR LCOR MAGEA1 MAGEA1 UHRF1BP1 UHRF1BP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000005860Prohibitin. (194 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
MIER3Mesoderm induction early response protein 3; Transcriptional repressor. (550 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
BRMS1Uncharacterized protein. (262 aa)
MEF2BMyocyte enhancer factor 2B. (388 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSMFAP00000000647WD_REPEATS_REGION domain-containing protein. (410 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
TBX2T-box transcription factor 2. (639 aa)
WDTC1WD and tetratricopeptide repeats 1. (687 aa)
MYOCDMyocardin. (964 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ENSMFAP00000001828CAF1C_H4-bd domain-containing protein. (103 aa)
HDAC10Histone deacetylase 10. (672 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (499 aa)
MAPK10Mitogen-activated protein kinase. (474 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
ENSMFAP00000005456Prohibitin. (239 aa)
ENSMFAP00000005566MAGE_N domain-containing protein. (104 aa)
THAP7THAP domain containing 7. (309 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
TFAP4Transcription factor AP-4. (299 aa)
ENSMFAP00000007313Prohibitin. (196 aa)
BCL3BCL3 transcription coactivator. (435 aa)
MIER2MIER family member 2. (545 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
HOXA10Homeobox A10. (410 aa)
SFPQSplicing factor proline and glutamine rich. (707 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] (603 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
LOC102126330Importin subunit alpha; Functions in nuclear protein import. (504 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
BEX4Brain expressed X-linked 4. (120 aa)
KCTD21Potassium channel tetramerization domain containing 21. (260 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
LOC102134827MAGE domain-containing protein. (314 aa)
ENSMFAP00000013287TNF receptor-associated factor. (474 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
PKN2Protein kinase N2. (983 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
ENSMFAP00000015493Uncharacterized protein. (235 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (328 aa)
GLI3GLI family zinc finger 3. (1579 aa)
MTA1Metastasis associated 1. (726 aa)
MAGEA11MAGE family member A11. (429 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
DDX20DEAD-box helicase 20. (856 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
CAMTA2Calmodulin binding transcription activator 2. (1223 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
RARARetinoic acid receptor alpha. (462 aa)
DHX36DEAH-box helicase 36. (1008 aa)
ENSMFAP00000018577Prohibitin. (236 aa)
HIF1AUncharacterized protein. (831 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
LOC102124602MAGE domain-containing protein. (300 aa)
ENSMFAP00000021335Prohibitin. (247 aa)
NACC2NACC family member 2. (586 aa)
KAT2BLysine acetyltransferase 2B. (731 aa)
SATB2DNA-binding protein SATB. (733 aa)
SRFSerum response factor. (508 aa)
ENSMFAP00000022925Prohibitin. (196 aa)
ANKRA2Ankyrin repeat family A member 2. (313 aa)
ENSMFAP00000024220WD_REPEATS_REGION domain-containing protein. (398 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
IKZF3IKAROS family zinc finger 3. (509 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1626 aa)
MIER1MIER1 transcriptional regulator. (565 aa)
HDAC6Histone deacetylase 6. (1215 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
MAGEA12MAGE family member A12. (297 aa)
ENSMFAP00000026376WD_REPEATS_REGION domain-containing protein. (381 aa)
HIC1HIC ZBTB transcriptional repressor 1. (733 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSMFAP00000027449WD_REPEATS_REGION domain-containing protein. (261 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (642 aa)
SP1Sp1 transcription factor. (786 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1016 aa)
NKX3-1NK3 homeobox 1. (232 aa)
MTA2Metastasis associated 1 family member 2. (673 aa)
C10orf90Chromosome 10 open reading frame 90. (796 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
NIPBLNipped-B protein. (2804 aa)
BHLHE41Basic helix-loop-helix family member e41. (482 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (690 aa)
BCORBCL6 corepressor. (1755 aa)
PHBProhibitin. (272 aa)
NACC1Nucleus accumbens associated 1. (429 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ENSMFAP00000033178MAGE domain-containing protein. (323 aa)
MAGEB5MAGE family member B5. (269 aa)
FOXP3Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The s [...] (456 aa)
CHD4Uncharacterized protein. (1912 aa)
PHF6PHD finger protein 6. (365 aa)
CBX5Chromobox 5. (191 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (260 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
PKN1Protein kinase N1. (949 aa)
ZMYND15Zinc finger MYND-type containing 15. (740 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
MTA3Metastasis associated 1 family member 3. (593 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
SP2Sp2 transcription factor. (613 aa)
PRDM1PR/SET domain 1. (825 aa)
ENSMFAP00000039407Importin subunit alpha; Functions in nuclear protein import. (446 aa)
CEBPBCCAAT/enhancer-binding protein. (314 aa)
CRY1Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] (586 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
RAD9ACell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa)
CIR1Corepressor interacting with RBPJ, 1. (374 aa)
TCF21Transcription factor 21. (179 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
ENSMFAP00000042484CAF1C_H4-bd domain-containing protein. (69 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
USF1Upstream transcription factor 1. (310 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (425 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
ENSMFAP00000044019WD_REPEATS_REGION domain-containing protein. (237 aa)
LCORLigand dependent nuclear receptor corepressor. (1556 aa)
MAGEA1MAGE family member A1. (309 aa)
UHRF1BP1UHRF1 binding protein 1. (1440 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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