STRINGSTRING
ZC3H12A ZC3H12A PPM1B PPM1B ZMYND11 ZMYND11 ADIPOQ ADIPOQ TNFAIP3 TNFAIP3 CACTIN CACTIN ABL1 ABL1 ENSMFAP00000043974 ENSMFAP00000043974 ESR1 ESR1 OTUD7A OTUD7A TRIM39 TRIM39 SIRT1 SIRT1 NR1D1 NR1D1 CASP8 CASP8 CCDC22 CCDC22 USP10 USP10 STAT1 STAT1 RIPK1 RIPK1 CARD19 CARD19 DNAJA3 DNAJA3 DAB2IP DAB2IP MAPKBP1 MAPKBP1 TLE1 TLE1 OPTN OPTN NLRC3 NLRC3 TNIP3 TNIP3 NLRP12 NLRP12 ENSMFAP00000025317 ENSMFAP00000025317 PER1 PER1 RORA RORA RIOK3 RIOK3 PYCARD PYCARD TREM2 TREM2 ENSMFAP00000016148 ENSMFAP00000016148 TNIP1 TNIP1 LILRB4 LILRB4 RHOH RHOH ASH1L ASH1L ENSMFAP00000010148 ENSMFAP00000010148 HDAC1 HDAC1 TANK TANK NR1H4 NR1H4 NLRX1 NLRX1 PPM1A PPM1A OTUD7B OTUD7B PPM1N PPM1N NLRP6 NLRP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
PPM1BProtein phosphatase, Mg2+/Mn2+ dependent 1B. (479 aa)
ZMYND11Zinc finger MYND-type containing 11. (648 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa)
CACTINCactin, spliceosome C complex subunit. (760 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
OTUD7AOTU deubiquitinase 7A. (748 aa)
TRIM39Tripartite motif containing 39. (518 aa)
SIRT1Sirtuin 1. (743 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa)
CCDC22Coiled-coil domain containing 22. (627 aa)
USP10Ubiquitin specific peptidase 10; Belongs to the peptidase C19 family. (810 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CARD19Caspase recruitment domain family member 19. (183 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1514 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (571 aa)
NLRC3NLR family CARD domain containing 3. (1026 aa)
TNIP3TNFAIP3 interacting protein 3. (432 aa)
NLRP12NLR family pyrin domain containing 12. (962 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
PER1Period circadian regulator 1. (1292 aa)
RORARAR related orphan receptor A. (555 aa)
RIOK3RIO kinase 3. (271 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ENSMFAP00000016148PPM-type phosphatase domain-containing protein. (280 aa)
TNIP1TNFAIP3 interacting protein 1. (637 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (448 aa)
RHOHRas homolog family member H. (191 aa)
ASH1LASH1 like histone lysine methyltransferase. (2967 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
NLRX1NLR family member X1. (972 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (433 aa)
NLRP6NLR family pyrin domain containing 6. (1044 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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