STRINGSTRING
ROR2 ROR2 DVL3 DVL3 SASH1 SASH1 MAP3K5 MAP3K5 TNF TNF AGER AGER ENSMFAP00000004486 ENSMFAP00000004486 AXIN1 AXIN1 ERN2 ERN2 EDN1 EDN1 MAP3K4 MAP3K4 FZD5 FZD5 TAOK3 TAOK3 FZD10 FZD10 ENSMFAP00000013287 ENSMFAP00000013287 Q9GMN5_MACFA Q9GMN5_MACFA FGD2 FGD2 ENSMFAP00000016477 ENSMFAP00000016477 MAP2K7 MAP2K7 PTPN1 PTPN1 SYK SYK TRAF2 TRAF2 TNFRSF11A TNFRSF11A MAP4K2 MAP4K2 MAP3K13 MAP3K13 MAP3K12 MAP3K12 ARHGEF5 ARHGEF5 MAP3K10 MAP3K10 DAB2IP DAB2IP EPHA4 EPHA4 PAK1 PAK1 PTK2B PTK2B WNT5A WNT5A DUSP19 DUSP19 FZD4 FZD4 DKK1 DKK1 MAP3K7 MAP3K7 ENSMFAP00000039612 ENSMFAP00000039612 CCL19 CCL19 TRAF6 TRAF6 ERN1 ERN1 DVL2 DVL2 FZD8 FZD8 MAP3K11 MAP3K11 RPS3 RPS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
SASH1SAM and SH3 domain containing 1. (1246 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
ENSMFAP00000004486Uncharacterized protein. (144 aa)
AXIN1Axin 1. (867 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (767 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1604 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TAOK3TAO kinase 3. (898 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ENSMFAP00000013287TNF receptor-associated factor. (474 aa)
Q9GMN5_MACFAUncharacterized protein. (83 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (655 aa)
ENSMFAP00000016477Uncharacterized protein. (137 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
SYKTyrosine-protein kinase. (635 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (825 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1597 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (883 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
EPHA4EPH receptor A4. (986 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (217 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSMFAP00000039612Uncharacterized protein. (175 aa)
CCL19C-C motif chemokine. (123 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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