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| | COLEC11 | C-type lectin domain-containing protein. (280 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | CRTAM | Cytotoxic and regulatory T cell molecule. (393 aa) |
| | NCR3 | Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. (201 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | HLA-E | Major histocompatibility complex, class I, E; Belongs to the MHC class I family. (382 aa) |
| | HLA-F | Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (443 aa) |
| | CASP6 | Uncharacterized protein; Belongs to the peptidase C14A family. (293 aa) |
| | ZNFX1 | Zinc finger NFX1-type containing 1. (1918 aa) |
| | ENSMFAP00000002918 | U1-type domain-containing protein. (555 aa) |
| | LOC102133652 | MHC_I-like_Ag-recog domain-containing protein. (263 aa) |
| | STING1 | Stimulator of interferon protein. (379 aa) |
| | ENSMFAP00000003951 | Ku domain-containing protein. (542 aa) |
| | LOC102131557 | Fibrinogen C-terminal domain-containing protein. (329 aa) |
| | LOC102122509 | C-type lectin domain-containing protein. (191 aa) |
| | POLR3F | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa) |
| | TLR8 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1058 aa) |
| | NECTIN2 | Nectin cell adhesion molecule 2. (538 aa) |
| | SH2D1A | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa) |
| | POLR3C | RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (294 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | PLSCR1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa) |
| | SH2D1B | SH2 domain containing 1B. (132 aa) |
| | KLRD1 | Killer cell lectin like receptor D1. (179 aa) |
| | PYHIN1 | Pyrin and HIN domain family member 1. (492 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | EREG | Epiregulin. (169 aa) |
| | USP27X | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa) |
| | LSM14A | LSM14A mRNA processing body assembly factor. (468 aa) |
| | LOC102132169 | C-type lectin domain-containing protein. (159 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa) |
| | AKIRIN2 | Akirin 2. (205 aa) |
| | MASP2 | Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | POLR3G | DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (223 aa) |
| | POLR3D | RNA polymerase III subunit D. (397 aa) |
| | PQBP1 | Polyglutamine binding protein 1. (265 aa) |
| | ENSMFAP00000014199 | HATPase_c domain-containing protein. (307 aa) |
| | TRIM62 | Tripartite motif containing 62. (475 aa) |
| | HEXIM1 | HEXIM P-TEFb complex subunit 1. (359 aa) |
| | TRIM56 | Tripartite motif containing 56. (755 aa) |
| | CXorf21 | Chromosome X open reading frame 21. (301 aa) |
| | UBE2K | Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (842 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (818 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (221 aa) |
| | ZBP1 | Z-DNA binding protein 1. (420 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (423 aa) |
| | AIM2 | Absent in melanoma 2. (348 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | MBL2 | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (255 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | ENSMFAP00000018412 | HATPase_c domain-containing protein. (644 aa) |
| | STAT5B | Signal transducer and activator of transcription. (763 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (216 aa) |
| | ENSMFAP00000018989 | Ku domain-containing protein. (498 aa) |
| | SLAMF6 | SLAM family member 6. (338 aa) |
| | PSPC1 | Paraspeckle component 1. (523 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | LAG3 | Lymphocyte activating 3. (529 aa) |
| | IRF3 | Interferon regulatory factor 3. (422 aa) |
| | SYK | Tyrosine-protein kinase. (635 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | PLA2G5 | Phospholipase A(2). (138 aa) |
| | MNDA | Myeloid cell nuclear differentiation antigen; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1 (By similarity). (407 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | ENSMFAP00000021023 | Ku domain-containing protein. (583 aa) |
| | RIOK3 | RIO kinase 3. (271 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | LOC102143922 | Uncharacterized protein. (499 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (893 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | COCH | Cochlin. (569 aa) |
| | CD160 | CD160 molecule. (233 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (495 aa) |
| | KIR2DL4 | Uncharacterized protein. (229 aa) |
| | ZCCHC3 | Zinc finger CCHC-type containing 3. (402 aa) |
| | LOC102132533 | C-type lectin domain-containing protein. (246 aa) |
| | LOC102133674 | Uncharacterized protein. (94 aa) |
| | LOC102138114 | AIG1-type G domain-containing protein. (323 aa) |
| | TRIM41 | Tripartite motif containing 41. (631 aa) |
| | ENSMFAP00000027951 | Matrin-type domain-containing protein. (255 aa) |
| | NMI | N-myc and STAT interactor. (307 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (729 aa) |
| | TIRAP | TIR domain-containing protein. (234 aa) |
| | KIR3DL3 | Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (316 aa) |
| | ULBP4 | MHC_I-like_Ag-recog domain-containing protein. (247 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | CD226 | CD226 molecule. (336 aa) |
| | RNF185 | Ring finger protein 185. (192 aa) |
| | MASP1 | Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (730 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (831 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (545 aa) |
| | XRCC6 | Testis cDNA, clone: QtsA-19002, similar to human thyroid autoantigen 70kDa (Ku antigen) (G22P1). (609 aa) |
| | RBM14 | Uncharacterized protein. (669 aa) |
| | ENSMFAP00000035310 | Uncharacterized protein. (328 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | IRGM | Immunity related GTPase M. (159 aa) |
| | ENSMFAP00000036774 | Ig-like domain-containing protein; Belongs to the MHC class I family. (365 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1117 aa) |
| | MMP12 | Matrix metallopeptidase 12. (470 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | POLR3B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (522 aa) |
| | CLNK | Cytokine dependent hematopoietic cell linker. (443 aa) |
| | IFI35 | Interferon induced protein 35. (286 aa) |
| | HPX | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa) |
| | NONO | Non-POU domain containing octamer binding. (471 aa) |
| | PVR | PVR cell adhesion molecule. (340 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | TYROBP | TYRO protein tyrosine kinase binding protein. (144 aa) |
| | ENSMFAP00000042558 | Uncharacterized protein. (170 aa) |
| | CADM1 | Cell adhesion molecule 1. (473 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | TOMM70 | Translocase of outer mitochondrial membrane 70. (608 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (820 aa) |
| | SLC15A4 | Solute carrier family 15 member 4. (496 aa) |
| | COLEC10 | Collectin subfamily member 10. (277 aa) |
| | TXK | Tyrosine-protein kinase. (527 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | ENSMFAP00000045157 | Uncharacterized protein. (205 aa) |
| | CLEC6A | C-type lectin domain containing 6A. (209 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | FCN3 | Ficolin 3. (299 aa) |
| | ENSMFAP00000046117 | Uncharacterized protein. (200 aa) |
| | MATR3 | Uncharacterized protein. (895 aa) |
