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| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | WDR48 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (714 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (510 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (223 aa) |
| | ENSMFAP00000027240 | Uncharacterized protein. (356 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ENSMFAP00000026582 | HMG box domain-containing protein. (177 aa) |
| | PHF10 | PHD finger protein 10. (469 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | ENSMFAP00000025930 | MRG domain-containing protein. (246 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (649 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1418 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (815 aa) |
| | MORF4L2 | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (288 aa) |
| | TMEM161A | Transmembrane protein 161A. (479 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | ENSMFAP00000022955 | Uncharacterized protein. (223 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa) |
| | PBRM1 | Polybromo 1. (1725 aa) |
| | ARID1B | AT-rich interaction domain 1B. (2295 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1496 aa) |
| | DDX11 | DEAD/H-box helicase 11. (906 aa) |
| | ENSMFAP00000020931 | Uncharacterized protein. (74 aa) |
| | DPF3 | Double PHD fingers 3. (275 aa) |
| | ENSMFAP00000019905 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (141 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2268 aa) |
| | SMARCD3 | SWIB domain-containing protein. (483 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (242 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (473 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | FUS | Uncharacterized protein. (530 aa) |
| | ENSMFAP00000016477 | Uncharacterized protein. (137 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1270 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (740 aa) |
| | KMT5B | Lysine methyltransferase 5B. (885 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (818 aa) |
| | Q9GMN5_MACFA | Uncharacterized protein. (83 aa) |
| | FOXM1 | Forkhead box M1. (770 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (612 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (155 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | ACTL6A | Actin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | ENSMFAP00000014022 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa) |
| | ENSMFAP00000013586 | Uncharacterized protein; Belongs to the actin family. (257 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | LOC102136325 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa) |
| | ENSMFAP00000012580 | DUF4502 domain-containing protein. (62 aa) |
| | ENSMFAP00000012317 | Uncharacterized protein. (59 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | ENSMFAP00000012243 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | ENSMFAP00000012051 | Reverse transcriptase domain-containing protein. (1217 aa) |
| | LOC102124821 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa) |
| | KMT5C | Lysine methyltransferase 5C. (461 aa) |
| | ENSMFAP00000007806 | EP400_N domain-containing protein. (401 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ENSMFAP00000009163 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa) |
| | HDGFL2 | HDGF like 2. (670 aa) |
| | FMN2 | Formin 2. (1729 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | DPF2 | Double PHD fingers 2. (405 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (364 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (316 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (279 aa) |
| | ENSMFAP00000001080 | Uncharacterized protein; Belongs to the actin family. (354 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | MRNIP | MRN complex interacting protein. (343 aa) |
| | EPC1 | Enhancer of polycomb homolog. (836 aa) |
| | MBTD1 | Mbt domain containing 1. (754 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | HDAC10 | Histone deacetylase 10. (672 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (889 aa) |
| | FAM178B | Uncharacterized protein. (679 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | INO80D | INO80 complex subunit D. (1027 aa) |
| | SPIRE1 | Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in [...] (757 aa) |
| | ENSMFAP00000004486 | Uncharacterized protein. (144 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | ENSMFAP00000004513 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa) |
| | ENSMFAP00000004985 | Uncharacterized protein. (90 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | WAS | WASP actin nucleation promoting factor. (503 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (548 aa) |
| | ENSMFAP00000006938 | MPN domain-containing protein. (285 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (368 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (244 aa) |
| | ENSMFAP00000007596 | FAM35_C domain-containing protein. (223 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | BRD8 | Bromodomain containing 8. (1235 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (714 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1247 aa) |
| | EP400 | E1A binding protein p400. (3136 aa) |
| | DHX9 | DExH-box helicase 9. (1275 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | ENSMFAP00000040574 | Uncharacterized protein. (130 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | TRIM28 | Tripartite motif containing 28. (721 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (510 aa) |
| | ENSMFAP00000039612 | Uncharacterized protein. (175 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (712 aa) |
| | ACTL6B | Actin like 6B; Belongs to the actin family. (426 aa) |
| | ARID2 | AT-rich interaction domain 2. (1815 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (202 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (493 aa) |
| | ENSMFAP00000037788 | Uncharacterized protein. (65 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | FANCB | FA complementation group B. (858 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa) |
| | MFSD11 | UNC93-like protein MFSD11. (449 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | SHLD1 | Shieldin complex subunit 1. (269 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (206 aa) |
| | SHLD2 | FAM35_C domain-containing protein. (991 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (445 aa) |
| | MRGBP | MRG domain binding protein. (204 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (238 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (352 aa) |
| | PCNA | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa) |
| | PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa) |
| | ENSMFAP00000030863 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (313 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1171 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | DPF1 | Double PHD fingers 1. (424 aa) |
