STRINGSTRING
P2RX7 P2RX7 HTR2A HTR2A MLST8 MLST8 ENSMFAP00000030824 ENSMFAP00000030824 MLXIPL MLXIPL INSR INSR ZBTB20 ZBTB20 MTOR MTOR ARNT ARNT PRKAA1 PRKAA1 RPTOR RPTOR PSEN1 PSEN1 APP APP SLC4A4 SLC4A4 PRXL2C PRXL2C IGF1 IGF1 GPD1 GPD1 PRKAA2 PRKAA2 LOC102140140 LOC102140140 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSMFAP00000030824Uncharacterized protein. (188 aa)
MLXIPLUncharacterized protein. (244 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
SLC4A4Anion exchange protein. (1100 aa)
PRXL2CUncharacterized protein. (226 aa)
IGF1Insulin like growth factor 1. (159 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
LOC102140140BHLH domain-containing protein. (412 aa)
HIF1AUncharacterized protein. (831 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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