STRINGSTRING
HNF1A HNF1A GABBR1 GABBR1 CRH CRH SPINK1 SPINK1 ADCY8 ADCY8 SIRT6 SIRT6 SRI SRI RPH3AL RPH3AL TRPM2 TRPM2 GAL GAL BAIAP3 BAIAP3 FGG FGG NR1H4 NR1H4 DOC2B DOC2B INHA INHA GIP GIP NR0B2 NR0B2 CFTR CFTR FOXL2 FOXL2 SNX4 SNX4 EDN1 EDN1 BMP6 BMP6 RAB8B RAB8B DAB2 DAB2 HLA-DRB5 HLA-DRB5 RFX6 RFX6 HFE HFE TFR2 TFR2 ANO1 ANO1 LOC102136620 LOC102136620 GPR68 GPR68 P2RY1 P2RY1 FFAR1 FFAR1 C2CD2L C2CD2L SOX11 SOX11 TUNAR TUNAR MYRIP MYRIP PLA2G3 PLA2G3 ENSMFAP00000015614 ENSMFAP00000015614 SOX4 SOX4 CAPN10 CAPN10 GHRHR GHRHR ABAT ABAT HIF1A HIF1A TNFSF11 TNFSF11 PPP3CB PPP3CB NNAT NNAT NMB NMB MCU MCU GALR1 GALR1 ISL1 ISL1 PDX1 PDX1 BAD BAD GIPR GIPR INHBB INHBB TCF7L2 TCF7L2 DRD2 DRD2 OSBP OSBP TACR1 TACR1 GHRL GHRL GCK GCK ADCYAP1 ADCYAP1 GHRH GHRH AIMP1 AIMP1 LRRC8A LRRC8A FGB FGB STX4 STX4 FGA FGA GPLD1 GPLD1 NKX3-1 NKX3-1 FFAR4 FFAR4 TRH TRH C1QTNF6 C1QTNF6 IRS2 IRS2 VSNL1 VSNL1 RBP4 RBP4 NLGN2 NLGN2 ENSMFAP00000031019 ENSMFAP00000031019 ECRG4 ECRG4 ENSMFAP00000031517 ENSMFAP00000031517 PPARD PPARD TMF1 TMF1 SMAD4 SMAD4 PSMD9 PSMD9 C1QTNF3 C1QTNF3 ARHGEF7 ARHGEF7 SLC30A8 SLC30A8 PRKCE PRKCE PCK2 PCK2 GRP GRP VAMP8 VAMP8 RASL10B RASL10B BLK BLK SELENOT SELENOT PFKM PFKM INHBA INHBA SPP1 SPP1 VDR VDR CYP19A1 CYP19A1 RETN RETN C1QTNF12 C1QTNF12 MPC2 MPC2 PTPN11 PTPN11 PLA2G6 PLA2G6 C1QTNF1 C1QTNF1 TM7SF3 TM7SF3 GCG GCG CASR CASR GPER1 GPER1 EDN3 EDN3 ENSMFAP00000043772 ENSMFAP00000043772 ILDR1 ILDR1 CREB1 CREB1 ACSL4 ACSL4 TRPM4 TRPM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNF1AHNF1 homeobox A. (599 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1011 aa)
CRHCorticotropin releasing hormone. (196 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
SIRT6Sirtuin 6. (355 aa)
SRISorcin. (198 aa)
RPH3ALRabphilin 3A like (without C2 domains). (294 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1511 aa)
GALGalanin and GMAP prepropeptide. (143 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
FGGFibrinogen gamma chain. (453 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
GIPGastric inhibitory polypeptide. (153 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
FOXL2Forkhead box L2. (376 aa)
SNX4Sorting nexin 4. (450 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
DAB2DAB adaptor protein 2. (770 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
RFX6Regulatory factor X6. (928 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
TFR2Transferrin receptor 2. (798 aa)
ANO1Anoctamin. (986 aa)
LOC102136620Uncharacterized protein. (64 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FFAR1Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular c [...] (300 aa)
C2CD2LC2CD2 like. (707 aa)
SOX11Transcription factor SOX. (441 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
MYRIPMyosin VIIA and Rab interacting protein. (871 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
ENSMFAP00000015614Uncharacterized protein. (506 aa)
SOX4Transcription factor SOX. (474 aa)
CAPN10Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). (681 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (393 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
HIF1AUncharacterized protein. (831 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
NNATNeuronatin. (81 aa)
NMBNeuromedin B. (153 aa)
MCUMitochondrial calcium uniporter. (351 aa)
GALR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
BADBCL2 associated agonist of cell death. (167 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
INHBBInhibin subunit beta B. (360 aa)
TCF7L2Transcription factor 7 like 2. (542 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (682 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
GCKPhosphotransferase. (480 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
GHRHGrowth hormone releasing hormone. (108 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
FGBFibrinogen beta chain. (491 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
FGAFibrinogen alpha chain. (928 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
NKX3-1NK3 homeobox 1. (232 aa)
FFAR4Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)- coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates [...] (377 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (234 aa)
C1QTNF6C1q and TNF related 6. (278 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
VSNL1Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. (191 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
NLGN2Neuroligin 2. (849 aa)
ENSMFAP00000031019Uncharacterized protein. (98 aa)
ECRG4ECRG4 augurin precursor. (148 aa)
ENSMFAP00000031517Uncharacterized protein. (262 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
TMF1TATA element modulatory factor 1. (1095 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PSMD9PDZ domain-containing protein. (223 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
GRPGastrin releasing peptide. (100 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
RASL10BRAS like family 10 member B. (203 aa)
BLKTyrosine-protein kinase. (505 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
INHBAInhibin subunit beta A. (426 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
VDRVitamin D receptor. (477 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
RETNUncharacterized protein. (65 aa)
C1QTNF12C1q and TNF related 12. (177 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
C1QTNF1C1q and TNF related 1. (282 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
GCGGlucagon. (180 aa)
CASRCalcium sensing receptor. (1078 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
EDN3Endothelin 3. (211 aa)
ENSMFAP00000043772Uncharacterized protein. (457 aa)
ILDR1Immunoglobulin like domain containing receptor 1. (546 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1214 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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