STRINGSTRING
SLIT2 SLIT2 TGFB1 TGFB1 ABHD2 ABHD2 TRERF1 TRERF1 NR3C1 NR3C1 UBE3A UBE3A TSPO TSPO AXIN2 AXIN2 RHOXF1 RHOXF1 CCN2 CCN2 SCNN1G SCNN1G SCNN1B SCNN1B HNRNPU HNRNPU BPIFB2 BPIFB2 MAOB MAOB LOC102134747 LOC102134747 RHOA RHOA SMYD3 SMYD3 TNF TNF ENSMFAP00000002824 ENSMFAP00000002824 GPR83 GPR83 PADI2 PADI2 LOC102135334 LOC102135334 ADM ADM NR2E1 NR2E1 NR4A3 NR4A3 PTPRU PTPRU NR1H3 NR1H3 CALCOCO1 CALCOCO1 RXRG RXRG SCGB2A1 SCGB2A1 AQP1 AQP1 NPAS4 NPAS4 ENSMFAP00000005456 ENSMFAP00000005456 TGFB2 TGFB2 PARP1 PARP1 ENSMFAP00000005860 ENSMFAP00000005860 ENSMFAP00000006010 ENSMFAP00000006010 ALPL ALPL ENSMFAP00000006397 ENSMFAP00000006397 ACSBG1 ACSBG1 TFAP4 TFAP4 NR3C2 NR3C2 CYBB CYBB ENSMFAP00000007313 ENSMFAP00000007313 AREG AREG PAM PAM ABCA2 ABCA2 TAT TAT BMP6 BMP6 METTL21C METTL21C DAB2 DAB2 BMP4 BMP4 TRIP4 TRIP4 PTGER2 PTGER2 ZFP36L2 ZFP36L2 UCP3 UCP3 ESRRB ESRRB ZFP36 ZFP36 SLIT3 SLIT3 MDK MDK PAQR8 PAQR8 ESRRG ESRRG BCL2 BCL2 CPN1 CPN1 ENSMFAP00000010678 ENSMFAP00000010678 CYP7B1 CYP7B1 FOS FOS ENSMFAP00000011662 ENSMFAP00000011662 LOC102140123 LOC102140123 NCOA2 NCOA2 CLDN4 CLDN4 TGFB3 TGFB3 SSTR3 SSTR3 MSTN MSTN DDX5 DDX5 LOC102139817 LOC102139817 PTGS2 PTGS2 PAQR7 PAQR7 ENSMFAP00000013942 ENSMFAP00000013942 SREBF1 SREBF1 SSTR2 SSTR2 PLPP1 PLPP1 HMGB1 HMGB1 SOX10 SOX10 CYP1B1 CYP1B1 GDNF GDNF PFKFB1 PFKFB1 IL1RN IL1RN GHRHR GHRHR GABRB1 GABRB1 WBP2 WBP2 ENSMFAP00000016996 ENSMFAP00000016996 PPARA PPARA TRIM63 TRIM63 STK39 STK39 PDCD7 PDCD7 RBFOX2 RBFOX2 ENSMFAP00000017801 ENSMFAP00000017801 SRC SRC FN1 FN1 BMP7 BMP7 CYBA CYBA ENSMFAP00000018577 ENSMFAP00000018577 IGFBP7 IGFBP7 ARID1A ARID1A PCSK1 PCSK1 THBS1 THBS1 ZFP36L1 ZFP36L1 DDIT4 DDIT4 DSG1 DSG1 USP8 USP8 ABCA3 ABCA3 ENSMFAP00000021335 ENSMFAP00000021335 HNF4A HNF4A ENSMFAP00000021707 ENSMFAP00000021707 NEDD4 NEDD4 ENSMFAP00000021872 ENSMFAP00000021872 ESRRA ESRRA NR2E3 NR2E3 ISL1 ISL1 BAD BAD ENSMFAP00000022925 ENSMFAP00000022925 ACOD1 ACOD1 ENSMFAP00000023610 ENSMFAP00000023610 RPS6KB1 RPS6KB1 TACR1 TACR1 DDX54 DDX54 ENSMFAP00000024148 ENSMFAP00000024148 ENSMFAP00000024195 ENSMFAP00000024195 HMGCS2 HMGCS2 LOX LOX AGL AGL SCGB1A1 SCGB1A1 WNT7B WNT7B CPS1 CPS1 ENSMFAP00000025201 ENSMFAP00000025201 ZMIZ1 ZMIZ1 GNRH1 GNRH1 MGARP MGARP ENSMFAP00000025529 ENSMFAP00000025529 SERPINF1 SERPINF1 ERRFI1 ERRFI1 RXRA RXRA CASP9 CASP9 UBR5 UBR5 URI1 URI1 FLT3 FLT3 YWHAH YWHAH PIK3CA PIK3CA POR POR ENSMFAP00000027857 ENSMFAP00000027857 SLC12A3 SLC12A3 ARG1 ARG1 FOSL1 FOSL1 ATP2B1 ATP2B1 NKX3-1 NKX3-1 HSD3B1 HSD3B1 SSTR5 SSTR5 PPARGC1B PPARGC1B ACVR1 ACVR1 ANXA1 ANXA1 PGR PGR TH TH PHB PHB RWDD1 RWDD1 AR AR ESR2 ESR2 ENSMFAP00000031547 ENSMFAP00000031547 PPARD PPARD TMF1 TMF1 YAP1 YAP1 ENSMFAP00000032273 ENSMFAP00000032273 CALCR CALCR IL10 IL10 IGF1R IGF1R ANXA3 ANXA3 AKR1C1 AKR1C1 CNGA3 CNGA3 ASS1 ASS1 PCK2 PCK2 JAK2 JAK2 RXRB RXRB ENSMFAP00000034570 ENSMFAP00000034570 ENSMFAP00000034629 ENSMFAP00000034629 AVPR1A AVPR1A TGFBR2 TGFBR2 COL1A1 COL1A1 PAPPA PAPPA CSN1S1 CSN1S1 NKX2-2 NKX2-2 ENG ENG ACR ACR AKR1C1-2 AKR1C1-2 ENSMFAP00000036496 ENSMFAP00000036496 IL22 IL22 ATP1A1 ATP1A1 FOSB FOSB CST11 CST11 NR1D1 NR1D1 SPP1 SPP1 GHSR GHSR DAXX DAXX REST REST ADTRP ADTRP EGLN2 EGLN2 MED1 MED1 DDX17 DDX17 KDM3A KDM3A GSK3A GSK3A SDC1 SDC1 CAV1 CAV1 HSD11B2 HSD11B2 EIF4E EIF4E POU4F2 POU4F2 CLDN1 CLDN1 NCOA4 NCOA4 PPP1R9B PPP1R9B ENSMFAP00000041998 ENSMFAP00000041998 ENSMFAP00000042133 ENSMFAP00000042133 GPER1 GPER1 OXT OXT PGRMC2 PGRMC2 IGFBP2 IGFBP2 ENSMFAP00000042558 ENSMFAP00000042558 BCKDHB BCKDHB ESR1 ESR1 FBXO32 FBXO32 BCL2L11 BCL2L11 RNF14 RNF14 TYMS TYMS MYOD1 MYOD1 ADAM9 ADAM9 NPC1 NPC1 IL6 IL6 ATP1A3 ATP1A3 AIFM1 AIFM1 ENSMFAP00000045157 ENSMFAP00000045157 STC1 STC1 HSD3B2 HSD3B2 FKBP4 FKBP4 ADIPOQ ADIPOQ NOTCH1 NOTCH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLIT2Slit guidance ligand 2. (1542 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ABHD2Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] (452 aa)
TRERF1Transcriptional regulating factor 1. (1218 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
TSPOTranslocator protein. (169 aa)
AXIN2Axin 2. (844 aa)
RHOXF1Rhox homeobox family member 1. (185 aa)
CCN2Connective tissue growth factor. (349 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (690 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (685 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
BPIFB2BPI fold containing family B member 2. (458 aa)
MAOBAmine oxidase. (520 aa)
LOC1021347473Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
RHOAUncharacterized protein. (141 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ENSMFAP00000002824Uncharacterized protein. (781 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (423 aa)
PADI2Peptidyl arginine deiminase 2. (665 aa)
LOC102135334Uncharacterized protein. (93 aa)
ADMAdrenomedullin. (185 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1447 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (690 aa)
RXRGRetinoid X receptor gamma. (463 aa)
SCGB2A1Secretoglobin family 2A member 1. (91 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
ENSMFAP00000005456Prohibitin. (239 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ENSMFAP00000005860Prohibitin. (194 aa)
ENSMFAP00000006010Uncharacterized protein. (370 aa)
ALPLAlkaline phosphatase. (524 aa)
ENSMFAP000000063973Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (361 aa)
ACSBG1Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. (758 aa)
TFAP4Transcription factor AP-4. (299 aa)
NR3C2Nuclear receptor subfamily 3 group C member 2. (988 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ENSMFAP00000007313Prohibitin. (196 aa)
AREGAmphiregulin. (274 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (976 aa)
ABCA2ATP binding cassette subfamily A member 2. (2469 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
METTL21CMethyltransferase like 21C. (284 aa)
DAB2DAB adaptor protein 2. (770 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TRIP4Thyroid hormone receptor interactor 4. (581 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
ZFP36L2ZFP36 ring finger protein like 2. (492 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
ESRRBEstrogen related receptor beta. (438 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
SLIT3Slit guidance ligand 3. (1480 aa)
MDKMidkine. (143 aa)
PAQR8Progestin and adipoQ receptor family member 8. (354 aa)
ESRRGEstrogen related receptor gamma. (470 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
CPN1Carboxypeptidase N subunit 1. (459 aa)
ENSMFAP00000010678Uncharacterized protein. (111 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSMFAP00000011662Uncharacterized protein. (111 aa)
LOC102140123Ubiquitin-conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
LOC102139817Uncharacterized protein. (446 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PAQR7Progestin and adipoQ receptor family member 7. (346 aa)
ENSMFAP00000013942UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (221 aa)
SOX10SRY-box transcription factor 10. (467 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity). Belongs to the IL-1 family. (179 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (393 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
WBP2WW domain binding protein 2. (261 aa)
ENSMFAP00000016996HECT domain-containing protein. (736 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
TRIM63Tripartite motif containing 63. (383 aa)
STK39Serine/threonine kinase 39. (548 aa)
PDCD7Programmed cell death 7. (488 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (448 aa)
ENSMFAP00000017801Uncharacterized protein. (170 aa)
SRCTyrosine-protein kinase. (542 aa)
FN1Fibronectin 1. (2477 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
ENSMFAP00000018577Prohibitin. (236 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
ARID1AAT-rich interaction domain 1A. (2268 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
THBS1Thrombospondin 1. (1173 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1051 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1118 aa)
ABCA3ATP binding cassette subfamily A member 3. (1704 aa)
ENSMFAP00000021335Prohibitin. (247 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ENSMFAP00000021707Nuclear receptor domain-containing protein. (255 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
ENSMFAP00000021872Uncharacterized protein. (203 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NR2E3Nuclear receptor subfamily 2 group E member 3. (462 aa)
ISL1ISL LIM homeobox 1. (349 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ENSMFAP00000022925Prohibitin. (196 aa)
ACOD1Aconitate decarboxylase 1. (481 aa)
ENSMFAP00000023610Uncharacterized protein. (53 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (883 aa)
ENSMFAP00000024148Uncharacterized protein. (155 aa)
ENSMFAP00000024195ABC transporter domain-containing protein. (194 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
LOXLysyl oxidase. (417 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
ENSMFAP00000025201Uncharacterized protein. (423 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
ENSMFAP00000025529SRCR domain-containing protein; Belongs to the eukaryotic initiation factor 4E family. (184 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (406 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
RXRARetinoid X receptor alpha. (443 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2799 aa)
URI1URI1 prefoldin like chaperone. (547 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1028 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
ENSMFAP00000027857Uncharacterized protein. (375 aa)
SLC12A3Solute carrier family 12 member 3. (1030 aa)
ARG1Arginase. (322 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
NKX3-1NK3 homeobox 1. (232 aa)
HSD3B1Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (373 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (223 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ANXA1Annexin. (346 aa)
PGRProgesterone receptor. (936 aa)
THTyrosine hydroxylase. (529 aa)
PHBProhibitin. (272 aa)
RWDD1RWD domain containing 1. (243 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
ESR2Estrogen receptor 2. (530 aa)
ENSMFAP00000031547Uncharacterized protein. (178 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
TMF1TATA element modulatory factor 1. (1095 aa)
YAP1Yes associated protein 1. (506 aa)
ENSMFAP00000032273RWD domain-containing protein. (200 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (517 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ANXA3Annexin. (323 aa)
AKR1C1Aldo-keto reductase family 1 member C1 homolog; Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. May play a role in myelin formation. Can oxidize both 20-alpha- and 3-alpha-hydroxysteroids. Low activity towards 5-alpha-androstan-17-beta-ol-3-one. Can also act on non-steroidal substrates such as S-indan-1-ol, S-tetralol and 4- chromanol; Belongs to the aldo/keto reductase family. (323 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
ASS1Uncharacterized protein. (412 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
RXRBRetinoid X receptor beta. (537 aa)
ENSMFAP00000034570Uncharacterized protein. (265 aa)
ENSMFAP00000034629Uncharacterized protein. (122 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
PAPPAPappalysin 1. (1556 aa)
CSN1S1Casein alpha s1. (139 aa)
NKX2-2NK2 homeobox 2. (273 aa)
ENGEndoglin. (555 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (406 aa)
AKR1C1-2Aldo_ket_red domain-containing protein. (366 aa)
ENSMFAP00000036496RBR-type E3 ubiquitin transferase. (286 aa)
IL22Interleukin 22. (179 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
CST11Cystatin 11. (138 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
DAXXDeath domain associated protein. (740 aa)
RESTRE1 silencing transcription factor. (1095 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (733 aa)
KDM3ALysine demethylase 3A. (1321 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (379 aa)
EIF4EEukaryotic translation initiation factor 4E. (247 aa)
POU4F2POU domain protein. (408 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
NCOA4Nuclear receptor coactivator 4. (651 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (818 aa)
ENSMFAP000000419983Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (356 aa)
ENSMFAP00000042133HECT domain-containing protein. (55 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
OXTUncharacterized protein; Belongs to the vasopressin/oxytocin family. (153 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
IGFBP2Insulin like growth factor binding protein 2. (302 aa)
ENSMFAP00000042558Uncharacterized protein. (170 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (392 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
FBXO32F-box protein 32. (355 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
TYMSThymidylate synthetase. (313 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1261 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
ENSMFAP00000045157Uncharacterized protein. (205 aa)
STC1Stanniocalcin 1. (247 aa)
HSD3B2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2. (422 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
NOTCH1Notch receptor 1. (2556 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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