STRINGSTRING
GLI1 GLI1 NKX3-2 NKX3-2 HOXD13 HOXD13 GATA4 GATA4 AHI1 AHI1 RET RET SFRP1 SFRP1 AGR2 AGR2 PDX1 PDX1 CDX2 CDX2 TP63 TP63 PTK6 PTK6 WNT11 WNT11 DCHS1 DCHS1 SPDEF SPDEF HMGCS2 HMGCS2 SOX17 SOX17 YIPF6 YIPF6 FOXF2 FOXF2 CBFA2T2 CBFA2T2 RB1 RB1 BCL2 BCL2 ENSMFAP00000010678 ENSMFAP00000010678 FOXL1 FOXL1 FZD5 FZD5 ENSMFAP00000011662 ENSMFAP00000011662 SOX11 SOX11 OVOL2 OVOL2 TGFB3 TGFB3 ZIC3 ZIC3 MIXL1 MIXL1 LOC102139817 LOC102139817 SHOX2 SHOX2 SOX10 SOX10 GLI3 GLI3 C1GALT1 C1GALT1 SRC SRC NOTCH1 NOTCH1 EPB41L5 EPB41L5 ENSMFAP00000044590 ENSMFAP00000044590 PCSK5 PCSK5 ID2 ID2 MYOCD MYOCD TBX2 TBX2 FGFR2 FGFR2 TIGAR TIGAR TGFB1 TGFB1 DACT1 DACT1 MEGF8 MEGF8 ASCL1 ASCL1 KCNQ1 KCNQ1 CPS1 CPS1 ENSMFAP00000025201 ENSMFAP00000025201 NKX2-3 NKX2-3 STRA6 STRA6 GATA6 GATA6 ENSMFAP00000027857 ENSMFAP00000027857 RBPMS2 RBPMS2 SMO SMO HOXA5 HOXA5 CLDN18 CLDN18 SMAD2 SMAD2 GATA5 GATA5 ADA ADA CLMP CLMP NIPBL NIPBL BBS7 BBS7 FGF9 FGF9 ENSMFAP00000031547 ENSMFAP00000031547 SHH SHH EPHB3 EPHB3 PKD1 PKD1 YAP1 YAP1 SALL1 SALL1 ASS1 ASS1 GLI2 GLI2 PKDCC PKDCC CRKL CRKL FGF10 FGF10 COL3A1 COL3A1 TGFBR2 TGFBR2 CCKBR CCKBR SIX2 SIX2 WNT5A WNT5A NKX2-2 NKX2-2 LGR4 LGR4 SFRP2 SFRP2 PRDM1 PRDM1 CHD8 CHD8 RARB RARB ACVR2B ACVR2B NODAL NODAL TCF21 TCF21 IFT172 IFT172 DNAAF1 DNAAF1 HOXA13 HOXA13 PYY PYY IL6ST IL6ST VPS52 VPS52 TNF TNF IHH IHH CCDC103 CCDC103 CXCL8 CXCL8 FOXE1 FOXE1 KLF5 KLF5 SMAD3 SMAD3 EDNRB EDNRB EXT1 EXT1 ALX4 ALX4 CCDC39 CCDC39 TGFB2 TGFB2 HLX HLX ENSMFAP00000006010 ENSMFAP00000006010 OTC OTC COBL COBL KIT KIT ALDH1A2 ALDH1A2 CTNNB1 CTNNB1 BMP4 BMP4 FOXF1 FOXF1 NKX2-6 NKX2-6 PERCC1 PERCC1 TYMS TYMS PDGFC PDGFC CCDC40 CCDC40 HIF1A HIF1A SAV1 SAV1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLI1GLI family zinc finger 1. (1106 aa)
NKX3-2NK3 homeobox 2. (333 aa)
HOXD13Homeobox D13. (321 aa)
GATA4GATA binding protein 4. (425 aa)
AHI1Abelson helper integration site 1. (1196 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1117 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
CDX2Caudal type homeobox 2. (313 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
PTK6Tyrosine-protein kinase. (451 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
DCHS1Dachsous cadherin-related 1. (3295 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
SOX17Uncharacterized protein. (416 aa)
YIPF6Protein YIPF. (236 aa)
FOXF2Forkhead box F2. (411 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (614 aa)
RB1RB transcriptional corepressor 1. (928 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
ENSMFAP00000010678Uncharacterized protein. (111 aa)
FOXL1Forkhead box L1. (345 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ENSMFAP00000011662Uncharacterized protein. (111 aa)
SOX11Transcription factor SOX. (441 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ZIC3Zic family member 3. (488 aa)
MIXL1Mix paired-like homeobox. (232 aa)
LOC102139817Uncharacterized protein. (446 aa)
SHOX2Short stature homeobox 2. (355 aa)
SOX10SRY-box transcription factor 10. (467 aa)
GLI3GLI family zinc finger 3. (1579 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (371 aa)
SRCTyrosine-protein kinase. (542 aa)
NOTCH1Notch receptor 1. (2556 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
ENSMFAP00000044590A_deaminase domain-containing protein. (345 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1887 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
MYOCDMyocardin. (964 aa)
TBX2T-box transcription factor 2. (639 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (316 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)
MEGF8Multiple EGF like domains 8. (2840 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (644 aa)
CPS1Carbamoyl-phosphate synthase 1. (1500 aa)
ENSMFAP00000025201Uncharacterized protein. (423 aa)
NKX2-3NK2 homeobox 3. (364 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
GATA6GATA binding protein 6. (557 aa)
ENSMFAP00000027857Uncharacterized protein. (375 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
HOXA5Homeobox A5. (270 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GATA5GATA binding protein 5. (347 aa)
ADAA_deaminase domain-containing protein. (449 aa)
CLMPCXADR like membrane protein. (373 aa)
NIPBLNipped-B protein. (2804 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSMFAP00000031547Uncharacterized protein. (178 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
EPHB3EPH receptor B3. (1008 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4318 aa)
YAP1Yes associated protein 1. (506 aa)
SALL1Spalt like transcription factor 1. (1323 aa)
ASS1Uncharacterized protein. (412 aa)
GLI2GLI family zinc finger 2. (1561 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (432 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (513 aa)
SIX2SIX homeobox 2. (303 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NKX2-2NK2 homeobox 2. (273 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (924 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
PRDM1PR/SET domain 1. (825 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa)
RARBRetinoic acid receptor beta. (448 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
NODALNodal growth differentiation factor. (347 aa)
TCF21Transcription factor 21. (179 aa)
IFT172Intraflagellar transport 172. (1749 aa)
DNAAF1Dynein assembly factor 1, axonemal. (726 aa)
HOXA13Homeobox A13. (228 aa)
PYYPeptide YY. (97 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FOXE1Forkhead box E1. (373 aa)
KLF5Kruppel like factor 5. (457 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (507 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ALX4ALX homeobox 4. (409 aa)
CCDC39Coiled-coil domain containing 39. (1061 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HLXH2.0 like homeobox. (497 aa)
ENSMFAP00000006010Uncharacterized protein. (370 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
COBLCordon-bleu WH2 repeat protein. (1301 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (540 aa)
CTNNB1Catenin beta 1. (781 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FOXF1Forkhead box F1. (372 aa)
NKX2-6NK2 homeobox 6. (301 aa)
PERCC1Uncharacterized protein. (158 aa)
TYMSThymidylate synthetase. (313 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CCDC40Coiled-coil domain containing 40. (1145 aa)
HIF1AUncharacterized protein. (831 aa)
SAV1Uncharacterized protein. (384 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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