STRINGSTRING
IL18 IL18 TGFB1 TGFB1 CCN4 CCN4 FGFR2 FGFR2 MAP3K5 MAP3K5 VIP VIP MYOCD MYOCD ID2 ID2 XBP1 XBP1 IRAK1 IRAK1 TNF TNF DDR2 DDR2 CDKN1A CDKN1A PDGFRB PDGFRB ENSMFAP00000003951 ENSMFAP00000003951 GNA13 GNA13 IGFBP3 IGFBP3 NR4A3 NR4A3 NOS3 NOS3 PDCD4 PDCD4 ENSMFAP00000005456 ENSMFAP00000005456 SMPD3 SMPD3 ENSMFAP00000005860 ENSMFAP00000005860 BMPR1A BMPR1A ENSMFAP00000007313 ENSMFAP00000007313 CTNNB1 CTNNB1 EDN1 EDN1 BMP4 BMP4 MNAT1 MNAT1 EREG EREG HTR1B HTR1B ZNF143 ZNF143 S1PR1 S1PR1 TGFB3 TGFB3 DNMT1 DNMT1 P2RY6 P2RY6 PTGS2 PTGS2 NPY5R NPY5R S1PR2 S1PR2 IGF1 IGF1 CTNNBIP1 CTNNBIP1 MEF2D MEF2D MMP9 MMP9 CX3CL1 CX3CL1 PDGFB PDGFB ITGA2 ITGA2 AKT1 AKT1 SRC SRC BMPR2 BMPR2 CDKN1B CDKN1B CYBA CYBA ENSMFAP00000018577 ENSMFAP00000018577 ENSMFAP00000018989 ENSMFAP00000018989 RBM10 RBM10 NDRG2 NDRG2 IRAK4 IRAK4 IL12A IL12A NPR1 NPR1 THBS1 THBS1 TERT TERT EFEMP2 EFEMP2 ENSMFAP00000021023 ENSMFAP00000021023 SF1 SF1 ENSMFAP00000021335 ENSMFAP00000021335 PRKDC PRKDC FRS2 FRS2 FOXJ2 FOXJ2 ENSMFAP00000022925 ENSMFAP00000022925 TCF7L2 TCF7L2 NOX1 NOX1 RPS6KB1 RPS6KB1 NPR3 NPR3 TACR1 TACR1 HBEGF HBEGF IFNG IFNG BMP2 BMP2 CNN1 CNN1 CALCRL CALCRL MEF2C MEF2C NDRG4 NDRG4 MFN2 MFN2 PIK3CA PIK3CA RBPMS2 RBPMS2 PRKG1 PRKG1 PHB PHB CCDC142 CCDC142 FGF9 FGF9 PPARD PPARD MMP2 MMP2 STAT1 STAT1 TRIB1 TRIB1 APOD APOD PTGIR PTGIR IL10 IL10 IGF1R IGF1R XRCC6 XRCC6 PTEN PTEN TGFBR2 TGFBR2 AIF1 AIF1 IL6R IL6R SERPINF2 SERPINF2 GNA12 GNA12 NPPC NPPC NF1 NF1 SOD2 SOD2 NOTCH3 NOTCH3 DBH DBH ELANE ELANE ADAMTS1 ADAMTS1 ITGB3 ITGB3 GPER1 GPER1 IGFBP5 IGFBP5 ERN1 ERN1 VIPR2 VIPR2 TLR4 TLR4 FOXP1 FOXP1 XRCC5 XRCC5 ALOX12 ALOX12 HMOX1 HMOX1 IL6 IL6 TNFAIP3 TNFAIP3 ADIPOQ ADIPOQ PPARGC1A PPARGC1A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCN4Cellular communication network factor 4. (367 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
VIPVasoactive intestinal peptide. (170 aa)
MYOCDMyocardin. (964 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
XBP1BZIP domain-containing protein. (380 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (662 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ENSMFAP00000003951Ku domain-containing protein. (542 aa)
GNA13G protein subunit alpha 13. (377 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PDCD4Programmed cell death 4. (471 aa)
ENSMFAP00000005456Prohibitin. (239 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENSMFAP00000005860Prohibitin. (194 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSMFAP00000007313Prohibitin. (196 aa)
CTNNB1Catenin beta 1. (781 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
EREGEpiregulin. (169 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ZNF143Zinc finger protein 143. (638 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NPY5RNeuropeptide Y receptor Y5. (455 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
IGF1Insulin like growth factor 1. (159 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SRCTyrosine-protein kinase. (542 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
ENSMFAP00000018577Prohibitin. (236 aa)
ENSMFAP00000018989Ku domain-containing protein. (498 aa)
RBM10RNA binding motif protein 10. (995 aa)
NDRG2Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). (371 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NPR1Guanylate cyclase. (1061 aa)
THBS1Thrombospondin 1. (1173 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
ENSMFAP00000021023Ku domain-containing protein. (583 aa)
SF1Splicing factor 1. (655 aa)
ENSMFAP00000021335Prohibitin. (247 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FOXJ2Forkhead box J2. (574 aa)
ENSMFAP00000022925Prohibitin. (196 aa)
TCF7L2Transcription factor 7 like 2. (542 aa)
NOX1NADPH oxidase 1. (564 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (299 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NDRG4NDRG family member 4. (414 aa)
MFN2Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PHBProhibitin. (272 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
APODApolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity). (215 aa)
PTGIRProstaglandin I2 receptor. (386 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
XRCC6Testis cDNA, clone: QtsA-19002, similar to human thyroid autoantigen 70kDa (Ku antigen) (G22P1). (609 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IL6RInterleukin 6 receptor. (468 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
GNA12G protein subunit alpha 12. (381 aa)
NPPCNatriuretic peptide C. (126 aa)
NF1Neurofibromin 1. (2849 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
NOTCH3Notch receptor 3. (2300 aa)
DBHDopamine beta-hydroxylase. (620 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
IGFBP5Uncharacterized protein. (272 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (510 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
FOXP1Forkhead box P1. (693 aa)
XRCC5X-ray repair cross complementing 5. (820 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
HMOX1Uncharacterized protein. (288 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in [...] (790 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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