STRINGSTRING
TLR4 TLR4 IL18 IL18 TGFB1 TGFB1 CCN4 CCN4 FGFR2 FGFR2 MAP3K5 MAP3K5 ID2 ID2 XBP1 XBP1 IRAK1 IRAK1 TNF TNF DDR2 DDR2 PDGFRB PDGFRB NR4A3 NR4A3 ENSMFAP00000005456 ENSMFAP00000005456 SMPD3 SMPD3 ENSMFAP00000005860 ENSMFAP00000005860 BMPR1A BMPR1A ENSMFAP00000007313 ENSMFAP00000007313 EDN1 EDN1 BMP4 BMP4 MNAT1 MNAT1 EREG EREG HTR1B HTR1B ZNF143 ZNF143 S1PR1 S1PR1 DNMT1 DNMT1 P2RY6 P2RY6 PTGS2 PTGS2 NPY5R NPY5R IGF1 IGF1 MEF2D MEF2D MMP9 MMP9 CX3CL1 CX3CL1 PDGFB PDGFB ITGA2 ITGA2 AKT1 AKT1 SRC SRC CYBA CYBA ENSMFAP00000018577 ENSMFAP00000018577 IRAK4 IRAK4 THBS1 THBS1 TERT TERT ENSMFAP00000021335 ENSMFAP00000021335 FRS2 FRS2 FOXJ2 FOXJ2 ENSMFAP00000022925 ENSMFAP00000022925 NOX1 NOX1 RPS6KB1 RPS6KB1 HBEGF HBEGF CALCRL CALCRL MFN2 MFN2 PIK3CA PIK3CA RBPMS2 RBPMS2 PHB PHB FGF9 FGF9 MMP2 MMP2 STAT1 STAT1 IGF1R IGF1R TGFBR2 TGFBR2 AIF1 AIF1 IL6R IL6R SERPINF2 SERPINF2 NF1 NF1 NOTCH3 NOTCH3 ELANE ELANE ADAMTS1 ADAMTS1 ITGB3 ITGB3 IGFBP5 IGFBP5 ERN1 ERN1 FOXP1 FOXP1 ALOX12 ALOX12 HMOX1 HMOX1 IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CCN4Cellular communication network factor 4. (367 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
XBP1BZIP domain-containing protein. (380 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (662 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ENSMFAP00000005456Prohibitin. (239 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENSMFAP00000005860Prohibitin. (194 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSMFAP00000007313Prohibitin. (196 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
EREGEpiregulin. (169 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ZNF143Zinc finger protein 143. (638 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NPY5RNeuropeptide Y receptor Y5. (455 aa)
IGF1Insulin like growth factor 1. (159 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SRCTyrosine-protein kinase. (542 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
ENSMFAP00000018577Prohibitin. (236 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
THBS1Thrombospondin 1. (1173 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
ENSMFAP00000021335Prohibitin. (247 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FOXJ2Forkhead box J2. (574 aa)
ENSMFAP00000022925Prohibitin. (196 aa)
NOX1NADPH oxidase 1. (564 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
MFN2Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
PHBProhibitin. (272 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IL6RInterleukin 6 receptor. (468 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
NF1Neurofibromin 1. (2849 aa)
NOTCH3Notch receptor 3. (2300 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
IGFBP5Uncharacterized protein. (272 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
FOXP1Forkhead box P1. (693 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
HMOX1Uncharacterized protein. (288 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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