STRINGSTRING
MED12 MED12 CHST11 CHST11 WNT9B WNT9B TULP3 TULP3 FGFR2 FGFR2 MMP14 MMP14 SETD2 SETD2 SMAD3 SMAD3 BMP4 BMP4 WDR19 WDR19 ENSMFAP00000009633 ENSMFAP00000009633 ENSMFAP00000011824 ENSMFAP00000011824 TGFB3 TGFB3 GLI3 GLI3 MTHFD1L MTHFD1L RDH10 RDH10 NDST1 NDST1 PRRX1 PRRX1 SIX1 SIX1 GRHL2 GRHL2 EIF4A3 EIF4A3 TBX15 TBX15 PAX5 PAX5 DLX2 DLX2 TGFBR1 TGFBR1 TBX1 TBX1 SMAD2 SMAD2 SIX4 SIX4 NIPBL NIPBL IRX5 IRX5 FGF8 FGF8 TGFBR2 TGFBR2 SIX2 SIX2 FOXC2 FOXC2 RUNX2 RUNX2 HOXA1 HOXA1 IFT140 IFT140 NODAL NODAL TFAP2A TFAP2A MMP16 MMP16 SLC39A1 SLC39A1 HOXA2 HOXA2 ALX3 ALX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED12Mediator complex subunit 12. (2178 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (464 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2544 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WDR19WD repeat domain 19. (1348 aa)
ENSMFAP00000009633Uncharacterized protein. (245 aa)
ENSMFAP00000011824Uncharacterized protein; Belongs to the DEAD box helicase family. (387 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GLI3GLI family zinc finger 3. (1579 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (976 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
PRRX1Paired related homeobox 1. (245 aa)
SIX1SIX homeobox 1. (284 aa)
GRHL2Grainyhead like transcription factor 2. (626 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (412 aa)
TBX15T-box transcription factor 15. (602 aa)
PAX5Paired box 5. (391 aa)
DLX2Distal-less homeobox 2. (328 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TBX1T-box transcription factor 1. (441 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SIX4SIX homeobox 4. (780 aa)
NIPBLNipped-B protein. (2804 aa)
IRX5Iroquois homeobox 5. (483 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SIX2SIX homeobox 2. (303 aa)
FOXC2Forkhead box C2. (487 aa)
RUNX2RUNX family transcription factor 2. (627 aa)
HOXA1Homeobox A1. (335 aa)
IFT140Intraflagellar transport 140. (1475 aa)
NODALNodal growth differentiation factor. (347 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
SLC39A1Solute carrier family 39 member 1. (324 aa)
HOXA2Homeobox A2. (375 aa)
ALX3ALX homeobox 3. (343 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.