STRINGSTRING
PKD2 PKD2 STRA6 STRA6 EDNRA EDNRA FOXH1 FOXH1 CITED2 CITED2 MYLK MYLK PDGFRB PDGFRB TGFB2 TGFB2 BMPR1A BMPR1A ADAMTS9 ADAMTS9 EDN1 EDN1 BMP4 BMP4 ANGPTL3 ANGPTL3 GJA5 GJA5 NOG NOG EYA1 EYA1 FOLR1 FOLR1 SOX4 SOX4 HEY2 HEY2 BMPR2 BMPR2 PRRX1 PRRX1 NRP1 NRP1 EFEMP2 EFEMP2 FOXC1 FOXC1 JAG1 JAG1 SMAD7 SMAD7 SRF SRF TBX2 TBX2 MYOCD MYOCD APOB APOB WNT11 WNT11 NOTCH1 NOTCH1 LRP1 LRP1 HEY1 HEY1 FOXF1 FOXF1 ACVRL1 ACVRL1 HOXA13 HOXA13 HPGD HPGD NOTCH3 NOTCH3 NF1 NF1 TFAP2B TFAP2B HAND2 HAND2 PRDM1 PRDM1 SEC24B SEC24B ARID2 ARID2 ENG ENG HOXA1 HOXA1 FOXC2 FOXC2 COMP COMP FGF8 FGF8 COL3A1 COL3A1 ADGRF5 ADGRF5 DLL4 DLL4 NPRL3 NPRL3 PROX1 PROX1 LDLR LDLR CHD7 CHD7 LRP2 LRP2 TBX1 TBX1 TGFBR1 TGFBR1 FKBP10 FKBP10 ZMIZ1 ZMIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
STRA6Stimulated by retinoic acid 6. (707 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FOXH1Forkhead box H1. (366 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MYLKMyosin light chain kinase. (1914 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
EDN1Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (211 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
FOLR1Folate receptor alpha. (257 aa)
SOX4Transcription factor SOX. (474 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PRRX1Paired related homeobox 1. (245 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
FOXC1Forkhead box C1. (504 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD7Mothers against decapentaplegic homolog. (495 aa)
SRFSerum response factor. (508 aa)
TBX2T-box transcription factor 2. (639 aa)
MYOCDMyocardin. (964 aa)
APOBApolipoprotein B. (4555 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
NOTCH1Notch receptor 1. (2556 aa)
LRP1LDL receptor related protein 1. (4544 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
FOXF1Forkhead box F1. (372 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
HOXA13Homeobox A13. (228 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
NOTCH3Notch receptor 3. (2300 aa)
NF1Neurofibromin 1. (2849 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PRDM1PR/SET domain 1. (825 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1277 aa)
ARID2AT-rich interaction domain 2. (1815 aa)
ENGEndoglin. (555 aa)
HOXA1Homeobox A1. (335 aa)
FOXC2Forkhead box C2. (487 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (548 aa)
PROX1Prospero homeobox 1. (737 aa)
LDLRLow density lipoprotein receptor. (860 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
LRP2LDL receptor related protein 2. (4655 aa)
TBX1T-box transcription factor 1. (441 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
FKBP10Peptidylprolyl isomerase. (584 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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