STRINGSTRING
CDKN2A CDKN2A GHRL GHRL STK11 STK11 WNT10B WNT10B NGFR NGFR ENSMFAP00000025660 ENSMFAP00000025660 SERPINF1 SERPINF1 IFT52 IFT52 CD109 CD109 AIMP1 AIMP1 NLRC3 NLRC3 MEF2C MEF2C IFT80 IFT80 PDCD10 PDCD10 TGFBR1 TGFBR1 TRIM24 TRIM24 NKX3-1 NKX3-1 MTSS1 MTSS1 BRCA2 BRCA2 SLURP1 SLURP1 CDC73 CDC73 KDF1 KDF1 ENSMFAP00000030346 ENSMFAP00000030346 MMRN2 MMRN2 DAB2IP DAB2IP ZEB1 ZEB1 GATA3 GATA3 AR AR DLL4 DLL4 PEX2 PEX2 PPARD PPARD TBC1D31 TBC1D31 CEACAM1 CEACAM1 ENSMFAP00000010473 ENSMFAP00000010473 RB1 RB1 EREG EREG LIMS2 LIMS2 STK3 STK3 KRT4 KRT4 PHOX2B PHOX2B BMP4 BMP4 DAB2 DAB2 MEN1 MEN1 COL4A3 COL4A3 GDF5 GDF5 NFIB NFIB ROBO1 ROBO1 STAT1 STAT1 B4GALT1 B4GALT1 VASH1 VASH1 TINF2 TINF2 PTCH1 PTCH1 GDF2 GDF2 RUNX3 RUNX3 ATOH8 ATOH8 NKX2-8 NKX2-8 STK4 STK4 WDR77 WDR77 RIDA RIDA PAX6 PAX6 ALOX5 ALOX5 NR2F2 NR2F2 SFN SFN NUPR1 NUPR1 IL26 IL26 IL12A IL12A APOH APOH CAV2 CAV2 SAV1 SAV1 CDKN1B CDKN1B NOTCH1 NOTCH1 PRL PRL INTU INTU IFT57 IFT57 IRF6 IRF6 SOX9 SOX9 CPB2 CPB2 ACVRL1 ACVRL1 MAGED1 MAGED1 IFT172 IFT172 PTPRK PTPRK HPN HPN EAF2 EAF2 CAV1 CAV1 NF1 NF1 SNAI2 SNAI2 MED1 MED1 FBXW7 FBXW7 SFRP2 SFRP2 WDR13 WDR13 SPARC SPARC VDR VDR ATP5IF1 ATP5IF1 FLCN FLCN ENG ENG B2M B2M WNT5A WNT5A OVOL1 OVOL1 PTEN PTEN PTPRM PTPRM XDH XDH ATF2 ATF2 CDK6 CDK6 TGFB2 TGFB2 TGFBR3 TGFBR3 TNMD TNMD RAP1GAP RAP1GAP IFT74 IFT74 ATP5F1A ATP5F1A AQP11 AQP11 SYNJ2BP SYNJ2BP CDKN1C CDKN1C TNF TNF ENSMFAP00000002594 ENSMFAP00000002594 DLG1 DLG1 EFNB2 EFNB2 FGFR2 FGFR2 TGFB1 TGFB1 THBS1 THBS1 KRIT1 KRIT1 MCC MCC SFRP1 SFRP1 FLT1 FLT1 DUSP10 DUSP10 ISL1 ISL1 PDX1 PDX1 CASK CASK RGCC RGCC CNMD CNMD DRD2 DRD2 SULF1 SULF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2AANK_REP_REGION domain-containing protein. (160 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
NGFRNerve growth factor receptor. (427 aa)
ENSMFAP00000025660Uncharacterized protein. (342 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (406 aa)
IFT52Intraflagellar transport 52. (437 aa)
CD109CD109 molecule. (1444 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
NLRC3NLR family CARD domain containing 3. (1026 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
IFT80Intraflagellar transport 80. (777 aa)
PDCD10Programmed cell death protein 10. (212 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
NKX3-1NK3 homeobox 1. (232 aa)
MTSS1MTSS I-BAR domain containing 1. (795 aa)
BRCA2BRCA2 DNA repair associated. (3418 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (103 aa)
CDC73Cell division cycle 73. (531 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
ENSMFAP00000030346ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (411 aa)
MMRN2Multimerin 2. (951 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
GATA3GATA binding protein 3. (444 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
PEX2Peroxisomal biogenesis factor 2. (323 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
TBC1D31Uncharacterized protein. (1067 aa)
CEACAM1Uncharacterized protein. (525 aa)
ENSMFAP00000010473Uncharacterized protein. (212 aa)
RB1RB transcriptional corepressor 1. (928 aa)
EREGEpiregulin. (169 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
STK3Serine/threonine kinase 3. (519 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (520 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DAB2DAB adaptor protein 2. (770 aa)
MEN1Menin 1. (615 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
GDF5Growth differentiation factor 5. (499 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
VASH1Vasohibin 1. (365 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
PTCH1Patched 1. (1398 aa)
GDF2Growth differentiation factor 2. (429 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
ATOH8Atonal bHLH transcription factor 8. (321 aa)
NKX2-8NK2 homeobox 8. (236 aa)
STK4Serine/threonine kinase 4. (487 aa)
WDR77WD repeat domain 77. (342 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
PAX6Uncharacterized protein. (462 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
IL26Interleukin 26. (198 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
APOHUncharacterized protein. (355 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
SAV1Uncharacterized protein. (384 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
NOTCH1Notch receptor 1. (2556 aa)
PRLProlactin. (227 aa)
INTUInturned planar cell polarity protein. (942 aa)
IFT57Intraflagellar transport 57. (429 aa)
IRF6Interferon regulatory factor 6. (467 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CPB2Carboxypeptidase B2. (423 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
MAGED1MAGE family member D1. (834 aa)
IFT172Intraflagellar transport 172. (1749 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1471 aa)
HPNHepsin; Belongs to the peptidase S1 family. (471 aa)
EAF2ELL associated factor 2. (263 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NF1Neurofibromin 1. (2849 aa)
SNAI2Uncharacterized protein. (268 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
WDR13WD repeat domain 13. (485 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
VDRVitamin D receptor. (477 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
FLCNFolliculin. (579 aa)
ENGEndoglin. (555 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (119 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
XDHXanthine dehydrogenase. (1333 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
TNMDTenomodulin. (317 aa)
RAP1GAPRAP1 GTPase activating protein. (750 aa)
IFT74Testis cDNA, clone: QtsA-18855, similar to human coiled-coil domain containing 2 (CCDC2). (600 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (584 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
CDKN1CUncharacterized protein. (215 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ENSMFAP00000002594Protein kinase domain-containing protein. (351 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
THBS1Thrombospondin 1. (1173 aa)
KRIT1Uncharacterized protein. (736 aa)
MCCMCC regulator of WNT signaling pathway. (1014 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
DUSP10Dual specificity phosphatase 10. (488 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
RGCCRegulator of cell cycle. (137 aa)
CNMDChondromodulin. (333 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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