STRINGSTRING
TGFB1 TGFB1 ABCG1 ABCG1 FRMD4A FRMD4A HNF1A HNF1A ENSMFAP00000002824 ENSMFAP00000002824 PTPN23 PTPN23 NR1H2 NR1H2 TRPM4 TRPM4 ACSL4 ACSL4 ADAM9 ADAM9 MYH10 MYH10 TLR4 TLR4 BSG BSG EXOC1 EXOC1 GPER1 GPER1 CASR CASR ADCY8 ADCY8 ARF6 ARF6 SIRT6 SIRT6 VEGFC VEGFC ANKRD1 ANKRD1 BLK BLK ACHE ACHE PFKM PFKM KCNN4 KCNN4 C1QTNF12 C1QTNF12 MPC2 MPC2 PLA2G6 PLA2G6 TM7SF3 TM7SF3 MYOM1 MYOM1 SRI SRI RPH3AL RPH3AL TRPM2 TRPM2 BAIAP3 BAIAP3 FGG FGG NR1H4 NR1H4 TGFB2 TGFB2 DOC2B DOC2B PPID PPID GIP GIP NR0B2 NR0B2 TTN TTN CFTR CFTR BMP6 BMP6 ENSMFAP00000008168 ENSMFAP00000008168 HLA-DRB5 HLA-DRB5 APBB3 APBB3 RFX6 RFX6 ANO1 ANO1 LOC102136620 LOC102136620 GPR68 GPR68 ENSMFAP00000010132 ENSMFAP00000010132 DNM1L DNM1L TLR2 TLR2 FFAR1 FFAR1 C2CD2L C2CD2L ENSMFAP00000011810 ENSMFAP00000011810 EXPH5 EXPH5 ENSMFAP00000012339 ENSMFAP00000012339 ENSMFAP00000012436 ENSMFAP00000012436 TGFB3 TGFB3 TUNAR TUNAR MYRIP MYRIP WLS WLS IGF1 IGF1 PARD6A PARD6A TMED10 TMED10 APBB1 APBB1 SOX4 SOX4 CAPN10 CAPN10 ADORA2A ADORA2A TREM2 TREM2 ABAT ABAT HIF1A HIF1A P2RX7 P2RX7 PPP3CB PPP3CB PCSK1 PCSK1 GCG GCG SYTL4 SYTL4 NNAT NNAT MCU MCU HMMR HMMR ISL1 ISL1 PDX1 PDX1 BAD BAD ATP13A2 ATP13A2 GIPR GIPR TCF7L2 TCF7L2 ADAM8 ADAM8 OSBP OSBP GHRL GHRL GCK GCK LOC101866362 LOC101866362 LRRC8A LRRC8A FGB FGB STX4 STX4 FGA FGA GOLPH3 GOLPH3 PLA2G1B PLA2G1B GPLD1 GPLD1 TRH TRH GOLPH3L GOLPH3L IRS2 IRS2 VSNL1 VSNL1 RBP4 RBP4 CD2AP CD2AP NLGN2 NLGN2 VPS35 VPS35 ENSMFAP00000031019 ENSMFAP00000031019 CD33 CD33 PPARD PPARD SEC24A SEC24A PSMD9 PSMD9 EZR EZR C1QTNF3 C1QTNF3 SLC30A8 SLC30A8 MYO18A MYO18A PRKCE PRKCE PCK2 PCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ABCG1ATP binding cassette subfamily G member 1. (690 aa)
FRMD4AFERM domain containing 4A. (1068 aa)
HNF1AHNF1 homeobox A. (599 aa)
ENSMFAP00000002824Uncharacterized protein. (781 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1633 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1214 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa)
BSGBasigin (Ok blood group). (366 aa)
EXOC1Exocyst complex component 1. (912 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CASRCalcium sensing receptor. (1078 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
SIRT6Sirtuin 6. (355 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
BLKTyrosine-protein kinase. (505 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (427 aa)
C1QTNF12C1q and TNF related 12. (177 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
MYOM1Myomesin 1. (1679 aa)
SRISorcin. (198 aa)
RPH3ALRabphilin 3A like (without C2 domains). (294 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1511 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
FGGFibrinogen gamma chain. (453 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PPIDUncharacterized protein. (370 aa)
GIPGastric inhibitory polypeptide. (153 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
TTNTitin. (32000 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
ENSMFAP00000008168Uncharacterized protein. (511 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
APBB3Amyloid beta precursor protein binding family B member 3. (580 aa)
RFX6Regulatory factor X6. (928 aa)
ANO1Anoctamin. (986 aa)
LOC102136620Uncharacterized protein. (64 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSMFAP00000010132Uncharacterized protein. (69 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
FFAR1Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular c [...] (300 aa)
C2CD2LC2CD2 like. (707 aa)
ENSMFAP00000011810Uncharacterized protein. (370 aa)
EXPH5Exophilin 5. (1990 aa)
ENSMFAP00000012339GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (117 aa)
ENSMFAP00000012436Uncharacterized protein. (370 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
MYRIPMyosin VIIA and Rab interacting protein. (871 aa)
WLSWnt ligand secretion mediator. (543 aa)
IGF1Insulin like growth factor 1. (159 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
TMED10Transmembrane p24 trafficking protein 10. (219 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (739 aa)
SOX4Transcription factor SOX. (474 aa)
CAPN10Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). (681 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
HIF1AUncharacterized protein. (831 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
GCGGlucagon. (180 aa)
SYTL4Synaptotagmin like 4. (670 aa)
NNATNeuronatin. (81 aa)
MCUMitochondrial calcium uniporter. (351 aa)
HMMRHyaluronan mediated motility receptor. (714 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1184 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
TCF7L2Transcription factor 7 like 2. (542 aa)
ADAM8ADAM metallopeptidase domain 8. (893 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (682 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
GCKPhosphotransferase. (480 aa)
LOC101866362Uncharacterized protein. (51 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
FGBFibrinogen beta chain. (491 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
FGAFibrinogen alpha chain. (928 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
PLA2G1BPhospholipase A(2). (148 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (234 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
IRS2Insulin receptor substrate 2. (1279 aa)
VSNL1Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. (191 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
CD2APCD2 associated protein. (639 aa)
NLGN2Neuroligin 2. (849 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
ENSMFAP00000031019Uncharacterized protein. (98 aa)
CD33CD33 molecule. (379 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1093 aa)
PSMD9PDZ domain-containing protein. (223 aa)
EZREzrin. (586 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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