STRINGSTRING
SIRPD SIRPD FCN3 FCN3 ENSMFAP00000045943 ENSMFAP00000045943 STAP1 STAP1 ADIPOQ ADIPOQ DOCK2 DOCK2 SCARB1 SCARB1 COLEC10 COLEC10 CD47 CD47 SYT11 SYT11 SNX3 SNX3 CAMK1D CAMK1D ATG5 ATG5 DNM2 DNM2 CSK CSK RAB31 RAB31 TMEM147 TMEM147 GATA2 GATA2 PRTN3 PRTN3 MFGE8 MFGE8 APOA1 APOA1 FGR FGR NOD2 NOD2 ATG3 ATG3 PTX3 PTX3 PTPRJ PTPRJ ITGAV ITGAV AZU1 AZU1 ENSMFAP00000034370 ENSMFAP00000034370 LOC102132156 LOC102132156 AHSG AHSG RAB27A RAB27A ABCA7 ABCA7 MYO18A MYO18A ANO6 ANO6 FER1L5 FER1L5 MASP1 MASP1 PRKCG PRKCG PLCG2 PLCG2 SIRPA SIRPA TGM2 TGM2 LOC102139733 LOC102139733 SIRPG SIRPG SFTPD SFTPD IL15RA IL15RA ALOX15 ALOX15 PTPRC PTPRC C3 C3 PIP4P2 PIP4P2 BCR BCR LMAN2 LMAN2 SLC11A1 SLC11A1 CD36 CD36 APPL2 APPL2 GAS6 GAS6 IL2RG IL2RG IL15 IL15 SYT7 SYT7 RACK1 RACK1 BTK BTK IL1B IL1B HCK HCK LETMD1 LETMD1 PLA2G5 PLA2G5 PYCARD PYCARD SYK SYK SPHK1 SPHK1 LYAR LYAR DYSF DYSF MERTK MERTK CYBA CYBA MBL2 MBL2 TUB TUB TREM2 TREM2 CLEC7A CLEC7A ITGA2 ITGA2 ENSMFAP00000017062 ENSMFAP00000017062 APOA2 APOA2 CD300LF CD300LF MASP2 MASP2 COLEC11 COLEC11 APPL1 APPL1 FCGR1A FCGR1A NCKAP1L NCKAP1L ENSMFAP00000008465 ENSMFAP00000008465 PLSCR1 PLSCR1 IL2RB IL2RB TULP1 TULP1 LOC102131557 LOC102131557 TNF TNF CALR CALR TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRPDSignal regulatory protein delta. (198 aa)
FCN3Ficolin 3. (299 aa)
ENSMFAP00000045943IGc1 domain-containing protein. (178 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1725 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
COLEC10Collectin subfamily member 10. (277 aa)
CD47CD47 molecule. (323 aa)
SYT11Uncharacterized protein. (431 aa)
SNX3Sorting nexin 3. (162 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
CSKTyrosine-protein kinase. (450 aa)
RAB31RAB31, member RAS oncogene family. (194 aa)
TMEM147Transmembrane protein 147. (224 aa)
GATA2GATA binding protein 2. (480 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (258 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (267 aa)
FGRTyrosine-protein kinase. (529 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1117 aa)
ATG3Autophagy-related protein 3. (314 aa)
PTX3Pentraxin 3. (381 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1279 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
AZU1Azurocidin 1. (250 aa)
ENSMFAP00000034370Ig-like domain-containing protein. (163 aa)
LOC102132156Uncharacterized protein. (1744 aa)
AHSGAlpha 2-HS glycoprotein. (367 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
ABCA7ATP binding cassette subfamily A member 7. (2148 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2054 aa)
ANO6Anoctamin. (931 aa)
FER1L5Fer-1 like family member 5. (2060 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (730 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SIRPAUncharacterized protein. (507 aa)
TGM2Transglutaminase 2. (687 aa)
LOC102139733Uncharacterized protein. (397 aa)
SIRPGSignal regulatory protein gamma. (387 aa)
SFTPDSurfactant protein D. (375 aa)
IL15RAInterleukin 15 receptor subunit alpha. (253 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
C3Complement C3. (1663 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
LMAN2Lectin, mannose binding 2. (321 aa)
SLC11A1Solute carrier family 11 member 1. (547 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (666 aa)
GAS6Growth arrest specific 6. (657 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
SYT7Synaptotagmin 7. (686 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC- mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits [...] (393 aa)
BTKTyrosine-protein kinase. (659 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
HCKTyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] (525 aa)
LETMD1LETM1 domain containing 1. (362 aa)
PLA2G5Phospholipase A(2). (138 aa)
PYCARDPYD and CARD domain containing. (195 aa)
SYKTyrosine-protein kinase. (635 aa)
SPHK1Sphingosine kinase 1. (470 aa)
LYARUncharacterized protein. (379 aa)
DYSFDysferlin. (2070 aa)
MERTKMER proto-oncogene, tyrosine kinase. (1001 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (255 aa)
TUBTubby-like protein; Belongs to the TUB family. (562 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CLEC7AC-type lectin domain containing 7A. (281 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
ENSMFAP00000017062L-type lectin-like domain-containing protein. (124 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (132 aa)
CD300LFCD300 molecule like family member f. (306 aa)
MASP2Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
COLEC11C-type lectin domain-containing protein. (280 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
FCGR1AUncharacterized protein. (375 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSMFAP00000008465C-type lectin domain-containing protein. (249 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
IL2RBInterleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). (551 aa)
TULP1TUB like protein 1; Belongs to the TUB family. (551 aa)
LOC102131557Fibrinogen C-terminal domain-containing protein. (329 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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