STRINGSTRING
ZDHHC12 ZDHHC12 ARC ARC CDK5 CDK5 CACNG5 CACNG5 MAPK1 MAPK1 FLOT1 FLOT1 BAIAP3 BAIAP3 NR2E1 NR2E1 SNAP25 SNAP25 ADCY8 ADCY8 AGER AGER TNF TNF SLC8A2 SLC8A2 TNR TNR CCR2 CCR2 SLC24A1 SLC24A1 TACR2 TACR2 STAU1 STAU1 TSHZ3 TSHZ3 STX3 STX3 RIMS1 RIMS1 ENSMFAP00000036680 ENSMFAP00000036680 MPP2 MPP2 PRKCZ PRKCZ RAPSN RAPSN ADCY1 ADCY1 SLC1A1 SLC1A1 NRXN1 NRXN1 RETN RETN RGS14 RGS14 CRHR2 CRHR2 KCTD13 KCTD13 ITPR3 ITPR3 GPER1 GPER1 OXT OXT SLC8A3 SLC8A3 CNR1 CNR1 LAMA2 LAMA2 LRRTM2 LRRTM2 MME MME NALCN NALCN GRIK2 GRIK2 SHANK3 SHANK3 CA7 CA7 RELN RELN NFATC4 NFATC4 STX1A STX1A CLSTN1 CLSTN1 APP APP SNAP47 SNAP47 BRAF BRAF FMR1 FMR1 PLK2 PLK2 CACNG7 CACNG7 LOC102136620 LOC102136620 HAP1 HAP1 GRIN2B GRIN2B CNR2 CNR2 LRRTM1 LRRTM1 MPP6 MPP6 PINK1 PINK1 RAB3GAP1 RAB3GAP1 CA2 CA2 NOG NOG SLC1A3 SLC1A3 PTGS2 PTGS2 IGSF11 IGSF11 NTRK1 NTRK1 ADRA1A ADRA1A GRIN1 GRIN1 ROR2 ROR2 RIMS2 RIMS2 SHANK2 SHANK2 GRIN2D GRIN2D SLC24A2 SLC24A2 ADORA2A ADORA2A CACNB2 CACNB2 PRRT1 PRRT1 DLG4 DLG4 STX1B STX1B CACNG8 CACNG8 MECP2 MECP2 EIF2AK4 EIF2AK4 GFAP GFAP CACNG4 CACNG4 SLC4A8 SLC4A8 TACR1 TACR1 SERPINE2 SERPINE2 CCL2 CCL2 SHISA7 SHISA7 LGMN LGMN KMO KMO NPS NPS CLSTN2 CLSTN2 CACNB4 CACNB4 NTRK2 NTRK2 GRIN2C GRIN2C STX4 STX4 CRTC1 CRTC1 SYT12 SYT12 DTNBP1 DTNBP1 NLGN2 NLGN2 RIMS3 RIMS3 NLGN1 NLGN1 ZDHHC2 ZDHHC2 NPTN NPTN GRIN2A GRIN2A LGI1 LGI1 RASGRF2 RASGRF2 PRKCE PRKCE EPHB2 EPHB2 SYT1 SYT1 PTEN PTEN KIF5B KIF5B PTK2B PTK2B NMU NMU CACNG2 CACNG2 GIP GIP
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZDHHC12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (267 aa)
ARCActivity regulated cytoskeleton associated protein. (471 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (753 aa)
TNRTenascin R. (1358 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (912 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
STAU1Staufen double-stranded RNA binding protein 1. (577 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (302 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
ENSMFAP00000036680RWD domain-containing protein. (136 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (537 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
NRXN1Neurexin 1. (1507 aa)
RETNUncharacterized protein. (65 aa)
RGS14Regulator of G protein signaling 14. (566 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
OXTUncharacterized protein; Belongs to the vasopressin/oxytocin family. (153 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
CNR1Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (411 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
MMEMembrane metalloendopeptidase. (750 aa)
NALCNSodium leak channel, non-selective. (1759 aa)
GRIK2Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. M [...] (908 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1596 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
RELNReelin. (3464 aa)
NFATC4Nuclear factor of activated T cells 4. (918 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
CLSTN1Calsyntenin 1. (974 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
SNAP47Synaptosome associated protein 47. (463 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
FMR1Fragile X mental retardation 1. (632 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
LOC102136620Uncharacterized protein. (64 aa)
HAP1Huntingtin associated protein 1. (571 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
MPP6Uncharacterized protein; Belongs to the MAGUK family. (582 aa)
PINK1Protein kinase domain-containing protein. (581 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
CA2Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family. (260 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SLC1A3Amino acid transporter. (542 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IGSF11Immunoglobulin superfamily member 11. (431 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
ADRA1AAdrenoceptor alpha 1A. (462 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1742 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1062 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (664 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
PRRT1Proline rich transmembrane protein 1. (306 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (320 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1248 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (517 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
SLC4A8Anion exchange protein. (1093 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
SHISA7Shisa family member 7. (490 aa)
LGMNLegumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). (433 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (458 aa)
NPSNeuropeptide S. (89 aa)
CLSTN2Calsyntenin 2. (955 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1242 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
CRTC1CREB regulated transcription coactivator 1. (628 aa)
SYT12Synaptotagmin 12. (421 aa)
DTNBP1Dystrobrevin binding protein 1. (350 aa)
NLGN2Neuroligin 2. (849 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
NLGN1Neuroligin 1. (823 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
NPTNNeuroplastin. (398 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1237 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
EPHB2Uncharacterized protein. (468 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (422 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
NMUNeuromedin U. (115 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
GIPGastric inhibitory polypeptide. (153 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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