STRINGSTRING
DENND1B DENND1B BTNL8 BTNL8 BTN2A2 BTN2A2 BRAF BRAF KHDRBS1 KHDRBS1 HLA-DRB5 HLA-DRB5 VTCN1 VTCN1 PDE4B PDE4B THY1 THY1 CD276 CD276 ENSMFAP00000006091 ENSMFAP00000006091 BTN1A1 BTN1A1 MAPK1 MAPK1 TEC TEC ENSMFAP00000003900 ENSMFAP00000003900 BCL10 BCL10 CD3E CD3E PSEN1 PSEN1 EIF2B3 EIF2B3 BCAR1 BCAR1 HRAS HRAS PIK3CD PIK3CD LCP2 LCP2 TXK TXK ABL1 ABL1 UBE2N UBE2N EIF2B1 EIF2B1 PLCG1 PLCG1 ITK ITK TMEM269 TMEM269 ICOSLG ICOSLG CD247 CD247 FOXP3 FOXP3 ENSMFAP00000032863 ENSMFAP00000032863 FYB2 FYB2 ENSMFAP00000034329 ENSMFAP00000034329 CRKL CRKL CD28 CD28 PTPRJ PTPRJ LIME1 LIME1 ZAP70 ZAP70 RC3H1 RC3H1 BTN3A3 BTN3A3 SKAP1 SKAP1 CSK CSK FYB1 FYB1 PRKD2 PRKD2 WNK1 WNK1 BTN3A2 BTN3A2 IKBKB IKBKB TRAF6 TRAF6 ZNF683 ZNF683 RNF31 RNF31 SPPL3 SPPL3 HLA-DPB1 HLA-DPB1 NFKBIZ NFKBIZ NFKBID NFKBID CTLA4 CTLA4 GATA3 GATA3 PLCG2 PLCG2 MALT1 MALT1 RBCK1 RBCK1 ADA ADA FCHO1 FCHO1 CACNB3 CACNB3 PDE4D PDE4D PTPN22 PTPN22 PRAM1 PRAM1 EIF2B5 EIF2B5 PIK3CA PIK3CA PTPRC PTPRC CACNB4 CACNB4 EIF2B4 EIF2B4 TNFRSF21 TNFRSF21 EIF2B2 EIF2B2 STK11 STK11 RFTN1 RFTN1 THEMIS THEMIS RC3H2 RC3H2 HHLA2 HHLA2 PTPN6 PTPN6 ENSMFAP00000019905 ENSMFAP00000019905 INPP5D INPP5D ZC3H12A ZC3H12A IKBKG IKBKG LCK LCK CBLB CBLB THEMIS2 THEMIS2 UBE2NL UBE2NL ENSMFAP00000014022 ENSMFAP00000014022 ENSMFAP00000013287 ENSMFAP00000013287 CD8A CD8A FYN FYN LOC102136325 LOC102136325 ERMAP ERMAP RIPK2 RIPK2 SHB SHB LOC102124821 LOC102124821 STOML2 STOML2 ENSMFAP00000044590 ENSMFAP00000044590 BTNL9 BTNL9 DQB1 DQB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DENND1BDENN domain containing 1B. (786 aa)
BTNL8Butyrophilin like 8. (501 aa)
BTN2A2Uncharacterized protein. (519 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
KHDRBS1KH domain-containing protein. (443 aa)
HLA-DRB5Ig-like domain-containing protein. (286 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
PDE4BPhosphodiesterase. (736 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CD276CD276 molecule. (534 aa)
ENSMFAP00000006091Uncharacterized protein. (507 aa)
BTN1A1Butyrophilin subfamily 1 member A1. (526 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TECTyrosine-protein kinase. (630 aa)
ENSMFAP00000003900B30.2/SPRY domain-containing protein. (498 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (198 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
EIF2B3Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family. (452 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
TXKTyrosine-protein kinase. (527 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
EIF2B1Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. (306 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ITKTyrosine-protein kinase. (620 aa)
TMEM269Transmembrane protein 269. (244 aa)
ICOSLGUncharacterized protein. (312 aa)
CD247Uncharacterized protein. (168 aa)
FOXP3Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The s [...] (456 aa)
ENSMFAP00000032863Uncharacterized protein. (238 aa)
FYB2FYN binding protein 2. (729 aa)
ENSMFAP00000034329Ig-like domain-containing protein. (361 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CD28IGv domain-containing protein. (234 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1279 aa)
LIME1Uncharacterized protein. (292 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
RC3H1Ring finger and CCCH-type domains 1. (1141 aa)
BTN3A3Uncharacterized protein. (532 aa)
SKAP1Src kinase associated phosphoprotein 1. (359 aa)
CSKTyrosine-protein kinase. (450 aa)
FYB1FYN binding protein 1. (839 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
WNK1WNK lysine deficient protein kinase 1. (2835 aa)
BTN3A2Butyrophilin subfamily 3 member A2. (505 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ZNF683Zinc finger protein 683. (524 aa)
RNF31Uncharacterized protein. (1072 aa)
SPPL3Signal peptide peptidase like 3. (384 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (264 aa)
NFKBIZNFKB inhibitor zeta. (719 aa)
NFKBIDNFKB inhibitor delta. (469 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
GATA3GATA binding protein 3. (444 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MALT1MALT1 paracaspase. (824 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
ADAA_deaminase domain-containing protein. (449 aa)
FCHO1FCH domain only 1. (870 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
PDE4DPhosphodiesterase. (809 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
PRAM1PML-RARA regulated adaptor molecule 1. (698 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (543 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
EIF2B2Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
RFTN1Raftlin, lipid raft linker 1. (578 aa)
THEMISThymocyte selection associated. (680 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
HHLA2HERV-H LTR-associating 2. (426 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
ENSMFAP00000019905UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (141 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (978 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
LCKTyrosine-protein kinase. (342 aa)
CBLBCbl proto-oncogene B. (982 aa)
THEMIS2Thymocyte selection associated family member 2. (644 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSMFAP00000014022UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa)
ENSMFAP00000013287TNF receptor-associated factor. (474 aa)
CD8ACD8a molecule. (235 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC102136325UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa)
ERMAPErythroblast membrane associated protein (Scianna blood group). (475 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
SHBSH2 domain containing adaptor protein B. (510 aa)
LOC102124821UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa)
STOML2Stomatin like 2. (361 aa)
ENSMFAP00000044590A_deaminase domain-containing protein. (345 aa)
BTNL9Butyrophilin like 9. (343 aa)
DQB1Ig-like domain-containing protein. (156 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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