STRINGSTRING
ROCK1 ROCK1 HRAS HRAS EPHA7 EPHA7 LIG4 LIG4 SNCB SNCB PSEN1 PSEN1 RHOA RHOA MAX MAX HIPK2 HIPK2 DNAJC5 DNAJC5 DNAJC5B DNAJC5B GAPDH GAPDH ATN1 ATN1 STAMBP STAMBP CDK5 CDK5 AARS1 AARS1 ATF2 ATF2 CIT CIT SYNGAP1 SYNGAP1 NFATC4 NFATC4 APP APP SCN2A SCN2A SPG11 SPG11 BARHL1 BARHL1 RB1 RB1 BCL2 BCL2 AGTR2 AGTR2 THRB THRB ADARB1 ADARB1 NES NES NTRK1 NTRK1 POLB POLB CORO1A CORO1A NAE1 NAE1 NEFL NEFL FAM162A FAM162A HIF1A HIF1A BAX BAX TP63 TP63 ATM ATM CLN8 CLN8 PIGT PIGT TNFRSF21 TNFRSF21 FAIM2 FAIM2 TMTC4 TMTC4 NGFR NGFR CASP9 CASP9 BCL2L1 BCL2L1 BID BID CASP7 CASP7 SIAH1 SIAH1 FADD FADD ANGPT1 ANGPT1 ADNP ADNP BNIP3 BNIP3 STAMBPL1 STAMBPL1 TRPC5 TRPC5 OXR1 OXR1 AKT2 AKT2 NCSTN NCSTN FGF8 FGF8 KRAS KRAS NR4A2 NR4A2 CNTFR CNTFR RAPSN RAPSN SLC1A1 SLC1A1 POU4F3 POU4F3 TP53 TP53 TFAP2B TFAP2B NF1 NF1 AXL AXL DLX1 DLX1 ERBB3 ERBB3 DRAXIN DRAXIN APAF1 APAF1 GRIK2 GRIK2 AIFM1 AIFM1 BOK BOK PPARGC1A PPARGC1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EPHA7EPH receptor A7. (998 aa)
LIG4DNA ligase. (911 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
RHOAUncharacterized protein. (141 aa)
MAXBHLH domain-containing protein. (160 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
ATN1Atrophin 1. (1181 aa)
STAMBPSTAM binding protein. (424 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1343 aa)
NFATC4Nuclear factor of activated T cells 4. (918 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2442 aa)
BARHL1BarH like homeobox 1. (327 aa)
RB1RB transcriptional corepressor 1. (928 aa)
BCL2BCL2 apoptosis regulator. (242 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
THRBUncharacterized protein. (476 aa)
ADARB1Adenosine deaminase RNA specific B1. (783 aa)
NESNestin; Belongs to the intermediate filament family. (1619 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
CORO1ACoronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. (461 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (538 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
HIF1AUncharacterized protein. (831 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
PIGTUncharacterized protein. (580 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (315 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (867 aa)
NGFRNerve growth factor receptor. (427 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
BCL2L1BCL2 like 1. (233 aa)
BIDBH3 interacting domain death agonist. (244 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ANGPT1Angiopoietin 1. (498 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
BNIP3BCL2 interacting protein 3. (248 aa)
STAMBPL1STAM binding protein like 1. (461 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
OXR1Oxidation resistance 1. (874 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NCSTNNcstrn_small domain-containing protein. (721 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
POU4F3POU domain protein. (568 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
NF1Neurofibromin 1. (2849 aa)
AXLAXL receptor tyrosine kinase. (718 aa)
DLX1Homeobox domain-containing protein. (255 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1353 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (348 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
GRIK2Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. M [...] (908 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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