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RSAD1 RSAD1 CDKAL1 CDKAL1 DPYD DPYD ENSMFAP00000010629 ENSMFAP00000010629 POLD1 POLD1 ELP3 ELP3 ENSMFAP00000007997 ENSMFAP00000007997 SDHB SDHB NDUFS8 NDUFS8 NDUFS7 NDUFS7 ENSMFAP00000004971 ENSMFAP00000004971 NUBP1 NUBP1 ENSMFAP00000004276 ENSMFAP00000004276 ACO1 ACO1 INO80D INO80D ABCE1 ABCE1 EXO5 EXO5 ETFDH ETFDH MUTYH MUTYH DPH2 DPH2 ENSMFAP00000014864 ENSMFAP00000014864 MOCS1 MOCS1 NTHL1 NTHL1 SERP2 SERP2 PRIM2 PRIM2 NFU1 NFU1 RSAD2 RSAD2 DDX11 DDX11 DNA2 DNA2 NDUFS2 NDUFS2 CDK5RAP1 CDK5RAP1 REV3L REV3L CIAPIN1 CIAPIN1 IREB2 IREB2 POLE POLE NDUFS1 NDUFS1 LOC102133005 LOC102133005 ENSMFAP00000042602 ENSMFAP00000042602 ENSMFAP00000041397 ENSMFAP00000041397 CIAO3 CIAO3 DPH1 DPH1 NDUFV1 NDUFV1 NUBPL NUBPL ERCC2 ERCC2 LIAS LIAS NUBP2 NUBP2 PPAT PPAT SERP1 SERP1 BRIP1 BRIP1 RTEL1 RTEL1 ACO2 ACO2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
CDKAL1CDK5 regulatory subunit associated protein 1 like 1. (576 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1035 aa)
ENSMFAP00000010629Uncharacterized protein; Belongs to the complex I 49 kDa subunit family. (374 aa)
POLD1DNA polymerase. (1107 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (547 aa)
ENSMFAP00000007997DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
NDUFS8NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (210 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (213 aa)
ENSMFAP00000004971Uncharacterized protein. (320 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
ENSMFAP00000004276Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (263 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
INO80DINO80 complex subunit D. (1027 aa)
ABCE1ATP binding cassette subfamily E member 1. (599 aa)
EXO5Exonuclease 5. (373 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (619 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (550 aa)
DPH22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa)
ENSMFAP00000014864Uncharacterized protein. (88 aa)
MOCS1Molybdenum cofactor synthesis 1. (646 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (293 aa)
SERP2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (234 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
DNA2Uncharacterized protein. (948 aa)
NDUFS2Complex1_49kDa domain-containing protein; Belongs to the complex I 49 kDa subunit family. (463 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (601 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3127 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (312 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
NDUFS1NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By sim [...] (706 aa)
LOC102133005Flavodoxin-like domain-containing protein. (732 aa)
ENSMFAP00000042602Nfu_N domain-containing protein. (202 aa)
ENSMFAP00000041397Uncharacterized protein. (587 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (476 aa)
DPH12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (443 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (464 aa)
NUBPLNucleotide binding protein like. (319 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (768 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (72 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1247 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1352 aa)
ACO2Aconitase 2. (799 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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