STRINGSTRING
MAPK14 MAPK14 NOTCH1 NOTCH1 TBX20 TBX20 BMP10 BMP10 NKX2-5 NKX2-5 TGFBR2 TGFBR2 PTEN PTEN YAP1 YAP1 JARID2 JARID2 FGF9 FGF9 PIM1 PIM1 ERBB4 ERBB4 TGFBR1 TGFBR1 MEF2C MEF2C TBX5 TBX5 GATA6 GATA6 WNT2 WNT2 TP73 TP73 FGF20 FGF20 RUNX1 RUNX1 GLI1 GLI1 SAV1 SAV1 HEY2 HEY2 NOG NOG VGLL4 VGLL4 BMPR1A BMPR1A MAPK11 MAPK11 NRG1 NRG1 TGFBR3 TGFBR3 CITED2 CITED2 TBX2 TBX2 ZFPM2 ZFPM2 FGFR2 FGFR2 KCNK2 KCNK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK14Mitogen-activated protein kinase. (360 aa)
NOTCH1Notch receptor 1. (2556 aa)
TBX20T-box transcription factor 20. (447 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
YAP1Yes associated protein 1. (506 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1200 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
TBX5T-box transcription factor 5. (518 aa)
GATA6GATA binding protein 6. (557 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
GLI1GLI family zinc finger 1. (1106 aa)
SAV1Uncharacterized protein. (384 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
VGLL4Vestigial like family member 4. (296 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
NRG1Neuregulin 1. (713 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
TBX2T-box transcription factor 2. (639 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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