STRINGSTRING
TGFBR2 TGFBR2 DLG1 DLG1 FOXE1 FOXE1 TGFBR3 TGFBR3 ITGB6 ITGB6 TGFB2 TGFB2 TSHZ1 TSHZ1 COL11A2 COL11A2 SOX11 SOX11 TGFB3 TGFB3 WNT11 WNT11 WNT7A WNT7A WNT8A WNT8A TBX1 TBX1 WNT3A WNT3A SMAD2 SMAD2 CHD7 CHD7 SMAD4 SMAD4 LEF1 LEF1 WNT5A WNT5A JAG2 JAG2 FZD2 FZD2 LRRC32 LRRC32 ITGB8 ITGB8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
FOXE1Forkhead box E1. (373 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TSHZ1Teashirt zinc finger homeobox 1. (1097 aa)
COL11A2Collagen type XI alpha 2 chain. (1736 aa)
SOX11Transcription factor SOX. (441 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
TBX1T-box transcription factor 1. (441 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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