STRINGSTRING
ANGPTL4 ANGPTL4 GCKR GCKR SCARB1 SCARB1 GPIHBP1 GPIHBP1 ANGPTL8 ANGPTL8 LPL LPL CETP CETP SIRT1 SIRT1 APOA5 APOA5 MLXIPL MLXIPL FUNDC2 FUNDC2 ABCG5 ABCG5 SESN2 SESN2 RORA RORA APOC4 APOC4 C1QTNF3 C1QTNF3 LIPC LIPC ABCG8 ABCG8 MTLN MTLN IL18 IL18 PNPLA8 PNPLA8 XBP1 XBP1 NR1H3 NR1H3 NR1H4 NR1H4 GIP GIP ANGPTL3 ANGPTL3 MED13 MED13 FITM2 FITM2 G7PML3_MACFA G7PML3_MACFA APOC2 APOC2 LOC102140140 LOC102140140 HNF4A HNF4A PLA2G12B PLA2G12B DGAT2 DGAT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANGPTL4Angiopoietin like 4. (239 aa)
GCKRGlucokinase regulator. (625 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (184 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (497 aa)
SIRT1Sirtuin 1. (743 aa)
APOA5Apolipoprotein A5. (366 aa)
MLXIPLUncharacterized protein. (244 aa)
FUNDC2Uncharacterized protein. (189 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
SESN2Sestrin 2. (480 aa)
RORARAR related orphan receptor A. (555 aa)
APOC4Uncharacterized protein. (127 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
LIPCLipase C, hepatic type. (523 aa)
ABCG8ATP binding cassette subfamily G member 8. (673 aa)
MTLNMitoregulin. (118 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PNPLA8Patatin like phospholipase domain containing 8. (782 aa)
XBP1BZIP domain-containing protein. (380 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
GIPGastric inhibitory polypeptide. (153 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2174 aa)
FITM2Fat storage inducing transmembrane protein 2. (262 aa)
G7PML3_MACFAUncharacterized protein. (151 aa)
APOC2Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Belongs to the apolipoprotein C2 family. (101 aa)
LOC102140140BHLH domain-containing protein. (412 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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