STRINGSTRING
MYC MYC MAX MAX SCX SCX ARNTL2 ARNTL2 TFAP4 TFAP4 PRMT5 PRMT5 HDAC1 HDAC1 SNAI1 SNAI1 NEUROD1 NEUROD1 ENSMFAP00000010148 ENSMFAP00000010148 NEUROG1 NEUROG1 NEUROG2 NEUROG2 NEUROD2 NEUROD2 ASCL2 ASCL2 PTF1A PTF1A ATOH8 ATOH8 TCF12 TCF12 HIF1A HIF1A TCF3 TCF3 CLOCK CLOCK SREBF2 SREBF2 MYOG MYOG ASCL1 ASCL1 TAL1 TAL1 PER1 PER1 ENSMFAP00000025317 ENSMFAP00000025317 TCF15 TCF15 MYBBP1A MYBBP1A BHLHE41 BHLHE41 CIART CIART ZEB1 ZEB1 GATA3 GATA3 TCF4 TCF4 PPARG PPARG NR1D1 NR1D1 MITF MITF HAND2 HAND2 SNAI2 SNAI2 CRY1 CRY1 TCF21 TCF21 BHLHE40 BHLHE40 ARNTL ARNTL ENSMFAP00000043974 ENSMFAP00000043974 MYOD1 MYOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
MAXBHLH domain-containing protein. (160 aa)
SCXScleraxis bHLH transcription factor. (145 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa)
TFAP4Transcription factor AP-4. (299 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine resi [...] (620 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
NEUROG1Neurogenin 1. (237 aa)
NEUROG2Neurogenin 2. (272 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
PTF1APancreas associated transcription factor 1a. (329 aa)
ATOH8Atonal bHLH transcription factor 8. (321 aa)
TCF12Transcription factor 12. (706 aa)
HIF1AUncharacterized protein. (831 aa)
TCF3Transcription factor 3. (654 aa)
CLOCKClock circadian regulator. (850 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1142 aa)
MYOGMyogenin. (249 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (238 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
PER1Period circadian regulator 1. (1292 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
TCF15Transcription factor 15. (197 aa)
MYBBP1AMYB binding protein 1a. (1339 aa)
BHLHE41Basic helix-loop-helix family member e41. (482 aa)
CIARTCircadian associated repressor of transcription. (395 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
GATA3GATA binding protein 3. (444 aa)
TCF4Transcription factor 4. (773 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SNAI2Uncharacterized protein. (268 aa)
CRY1Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] (586 aa)
TCF21Transcription factor 21. (179 aa)
BHLHE40Basic helix-loop-helix family member e40. (412 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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