(67 nodes) Cellular senescence network (Macaca fascicularis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ENSMFAP00000023932	Uncharacterized protein. (256 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	ENSMFAP00000000767	Uncharacterized protein. (208 aa)
	CALR	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	TBX2	T-box transcription factor 2. (639 aa)
	ID2	DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
	ENSMFAP00000001669	Uncharacterized protein. (268 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	MAPK10	Mitogen-activated protein kinase. (474 aa)
	PML	Promyelocytic leukemia. (882 aa)
	MAPK11	Mitogen-activated protein kinase. (366 aa)
	ENSMFAP00000006058	Uncharacterized protein. (305 aa)
	ENSMFAP00000006551	Uncharacterized protein. (229 aa)
	HMGA1	Uncharacterized protein. (201 aa)
	NPM1	Uncharacterized protein. (305 aa)
	ENSMFAP00000010938	Uncharacterized protein. (107 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	ENSMFAP00000013555	Uncharacterized protein. (86 aa)
	ENSMFAP00000014690	Uncharacterized protein. (107 aa)
	ENSMFAP00000016028	Uncharacterized protein. (232 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (435 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	SMC6	Structural maintenance of chromosomes 6. (1092 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	SRF	Serum response factor. (508 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	WRN	WRN RecQ like helicase. (1428 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	CDKN2A	ANK_REP_REGION domain-containing protein. (160 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1073 aa)
	ENSMFAP00000025396	Uncharacterized protein. (274 aa)
	ENSMFAP00000025493	Uncharacterized protein. (274 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	ENSMFAP00000027412	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (308 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	ULK3	Unc-51 like kinase 3. (482 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1466 aa)
	BRCA2	BRCA2 DNA repair associated. (3418 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	MAPK9	Mitogen-activated protein kinase. (398 aa)
	ECRG4	ECRG4 augurin precursor. (148 aa)
	NUP62	Nucleoporin 62. (338 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	MIF	Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (474 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa)
	SIRT1	Sirtuin 1. (743 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
	MNT	MAX network transcriptional repressor. (582 aa)
	MAP2K6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (626 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (382 aa)
	SMC5	SMC_N domain-containing protein. (1044 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSMFAP00000045075	ENSMFAP00000022390	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.918
ABL1	CDKN1A	ENSMFAP00000045075	ENSMFAP00000003738	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Cyclin dependent kinase inhibitor 1A.	0.624
ABL1	CDKN1B	ENSMFAP00000045075	ENSMFAP00000018436	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Cyclin dependent kinase inhibitor 1B.	0.429
ABL1	HRAS	ENSMFAP00000045075	ENSMFAP00000000889	ABL proto-oncogene 1, non-receptor tyrosine kinase.	HRas proto-oncogene, GTPase.	0.516
ABL1	MAPK11	ENSMFAP00000045075	ENSMFAP00000006027	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Mitogen-activated protein kinase.	0.500
ABL1	MAPK14	ENSMFAP00000045075	ENSMFAP00000037420	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Mitogen-activated protein kinase.	0.501
ABL1	TP53	ENSMFAP00000045075	ENSMFAP00000038526	ABL proto-oncogene 1, non-receptor tyrosine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.599
ARNTL	SIRT1	ENSMFAP00000043176	ENSMFAP00000039959	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.770
ATM	ABL1	ENSMFAP00000022390	ENSMFAP00000045075	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ABL proto-oncogene 1, non-receptor tyrosine kinase.	0.918
ATM	BRCA2	ENSMFAP00000022390	ENSMFAP00000029418	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.924
ATM	CDK2	ENSMFAP00000022390	ENSMFAP00000026821	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.838
ATM	CDKN1A	ENSMFAP00000022390	ENSMFAP00000003738	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.452
ATM	CDKN2A	ENSMFAP00000022390	ENSMFAP00000024058	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ANK_REP_REGION domain-containing protein.	0.475
ATM	KAT6A	ENSMFAP00000022390	ENSMFAP00000043301	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.637
ATM	MAPK10	ENSMFAP00000022390	ENSMFAP00000003757	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.530
ATM	MAPK14	ENSMFAP00000022390	ENSMFAP00000037420	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.420
ATM	MAPK8	ENSMFAP00000022390	ENSMFAP00000037873	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.600
ATM	MAPK9	ENSMFAP00000022390	ENSMFAP00000030842	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.435
ATM	SIRT1	ENSMFAP00000022390	ENSMFAP00000039959	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.597
ATM	SMC5	ENSMFAP00000022390	ENSMFAP00000043260	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC_N domain-containing protein.	0.578

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