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| | PDK2 | Protein-serine/threonine kinase. (568 aa) |
| | PDK1 | Protein-serine/threonine kinase. (451 aa) |
| | ENSMFAP00000023078 | Uncharacterized protein; Belongs to the peptidase C14A family. (261 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | INHBB | Inhibin subunit beta B. (360 aa) |
| | KRT18 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | COA8 | Cytochrome c oxidase assembly factor 8. (206 aa) |
| | ENSMFAP00000022286 | Uncharacterized protein. (156 aa) |
| | PDX1 | Pancreatic and duodenal homeobox 1. (282 aa) |
| | CHEK2 | Checkpoint kinase 2. (589 aa) |
| | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1418 aa) |
| | BAG3 | BCL2 associated athanogene 3. (575 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | PDE3A | Phosphodiesterase. (1141 aa) |
| | CASP4 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1496 aa) |
| | ING5 | Inhibitor of growth family member 5. (252 aa) |
| | BBC3 | BCL2 binding component 3. (261 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (233 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa) |
| | SHISA5 | Shisa family member 5. (238 aa) |
| | SELENOK | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa) |
| | ENSMFAP00000020173 | PRA1 family protein. (186 aa) |
| | GGCT | Uncharacterized protein. (188 aa) |
| | ENSMFAP00000020125 | IF rod domain-containing protein; Belongs to the intermediate filament family. (123 aa) |
| | CIDEB | Cell death inducing DFFA like effector b. (220 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | ENSMFAP00000019681 | HIT domain-containing protein. (112 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (606 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (808 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (519 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (397 aa) |
| | ENSMFAP00000016524 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa) |
| | PIDD1 | P53-induced death domain protein 1. (910 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1502 aa) |
| | DAP3 | Death associated protein 3. (398 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1147 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (510 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | SLFN12 | Schlafen family member 12. (580 aa) |
| | STK4 | Serine/threonine kinase 4. (487 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | ENSMFAP00000014424 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | QRICH1 | Glutamine rich 1. (777 aa) |
| | RNF186 | Ring finger protein 186. (227 aa) |
| | ENSMFAP00000014001 | Uncharacterized protein. (91 aa) |
| | SKIL | SKI like proto-oncogene. (684 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | DAPL1 | Death associated protein like 1. (107 aa) |
| | DAPK3 | Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (100 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | CTTN | Cortactin. (550 aa) |
| | SSTR3 | Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | G0S2 | G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. (103 aa) |
| | PHLDA3 | Pleckstrin homology like domain family A member 3. (127 aa) |
| | ENSMFAP00000012338 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (311 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | ENSMFAP00000011486 | Uncharacterized protein. (702 aa) |
| | ITPRIPL2 | ITPRIP like 2. (535 aa) |
| | ENSMFAP00000011344 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
| | ENSMFAP00000010473 | Uncharacterized protein. (212 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | DNM1L | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa) |
| | ENSMFAP00000010121 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | ENSMFAP00000009961 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (404 aa) |
| | SLFN12L | Schlafen family member 12 like. (613 aa) |
| | RNF41 | Ring finger protein 41. (317 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1051 aa) |
| | BCL3 | BCL3 transcription coactivator. (435 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | METTL21C | Methyltransferase like 21C. (284 aa) |
| | FNIP2 | Folliculin interacting protein 2. (1153 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1820 aa) |
| | PCGF2 | Polycomb group ring finger 2. (344 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | MAEL | Protein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic n [...] (434 aa) |
| | CD24 | Uncharacterized protein. (127 aa) |
| | ZNF622 | Zinc finger protein 622. (477 aa) |
| | CD5 | CD5 molecule. (486 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (918 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (767 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (462 aa) |
| | ENSMFAP00000005981 | Uncharacterized protein. (471 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | PML | Promyelocytic leukemia. (882 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (445 aa) |
| | TNFSF12 | TNF superfamily member 12; Belongs to the tumor necrosis factor family. (250 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1594 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | PAWR | Pro-apoptotic WT1 regulator. (342 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (898 aa) |
| | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (979 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | ARL6IP5 | PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity- dependent manner. May be involved in membrane traffic. (188 aa) |
| | STK24 | Serine/threonine kinase 24. (443 aa) |
| | DEDD2 | Death effector domain containing 2. (326 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1132 aa) |
| | DIDO1 | Death inducer-obliterator 1. (2238 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (198 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (149 aa) |
| | MOAP1 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity); Belongs to the PNMA family. (351 aa) |
| | CASP6 | Uncharacterized protein; Belongs to the peptidase C14A family. (293 aa) |
| | BCL2A1 | BCL2 related protein A1. (175 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | HINT1 | HIT domain-containing protein. (126 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (385 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1374 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | BCL2L10 | Uncharacterized protein. (194 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (560 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (455 aa) |
| | DPF2 | Double PHD fingers 2. (405 aa) |
| | ENSMFAP00000045669 | SKIP_SNW domain-containing protein. (467 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1047 aa) |
| | TMEM109 | Transmembrane protein 109. (243 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1090 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa) |
| | MFF | Mitochondrial fission factor. (341 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (651 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (642 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | ENSMFAP00000044458 | Uncharacterized protein. (81 aa) |
| | RPS27L | 40S ribosomal protein S27. (100 aa) |
| | GSKIP | GSK3-beta interaction protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes ne [...] (144 aa) |
| | CRIP1 | LIM zinc-binding domain-containing protein. (77 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | CARD16 | CARD domain-containing protein. (97 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1353 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (978 aa) |
| | DEDD | Death effector domain containing. (347 aa) |
| | DELE1 | DAP3 binding cell death enhancer 1. (522 aa) |
| | NANOS3 | Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (193 aa) |
| | FASTK | Fas activated serine/threonine kinase. (531 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | RAD9A | Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN [...] (390 aa) |
| | CTNNA1 | Catenin alpha 1. (906 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa) |
| | ENSMFAP00000040724 | IF rod domain-containing protein; Belongs to the intermediate filament family. (426 aa) |
| | CD70 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (316 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (314 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | NF1 | Neurofibromin 1. (2849 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | RHOT2 | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (625 aa) |
| | VDAC2 | Uncharacterized protein. (308 aa) |
| | ST20 | Uncharacterized protein. (78 aa) |
| | DAXX | Death domain associated protein. (740 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa) |
| | HIP1 | Huntingtin interacting protein 1. (1038 aa) |
| | VDR | Vitamin D receptor. (477 aa) |
| | INHBA | Inhibin subunit beta A. (426 aa) |
| | TNFRSF25 | TNF receptor superfamily member 25. (420 aa) |
| | TMEM117 | Transmembrane protein 117. (514 aa) |
| | FLCN | Folliculin. (579 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (130 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | RHOT1 | Ras homolog family member T1. (752 aa) |
| | ENSMFAP00000036068 | Uncharacterized protein. (114 aa) |
| | PERP | PERP, TP53 apoptosis effector. (193 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1134 aa) |
| | CD28 | IGv domain-containing protein. (234 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa) |
| | JAK2 | Tyrosine-protein kinase. (1139 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | BNIP3L | Uncharacterized protein. (219 aa) |
| | BEX3 | Brain expressed X-linked 3. (123 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa) |
| | ANXA6 | Annexin. (680 aa) |
| | STAMBPL1 | STAM binding protein like 1. (461 aa) |
| | DAPK1 | Death associated protein kinase 1. (1440 aa) |
| | IFI27 | Interferon alpha inducible protein 27. (122 aa) |
| | IFI27L1 | Interferon alpha inducible protein 27 like 1. (93 aa) |
| | IFI27L2 | Interferon alpha inducible protein 27 like 2. (129 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | MKNK2 | MAPK interacting serine/threonine kinase 2. (454 aa) |
| | YAP1 | Yes associated protein 1. (506 aa) |
| | ENSMFAP00000031985 | Uncharacterized protein. (83 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | IL33 | Interleukin 33. (270 aa) |
| | BNIP3 | BCL2 interacting protein 3. (248 aa) |
| | CASP8AP2 | Caspase 8 associated protein 2. (1986 aa) |
| | ENSMFAP00000031451 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (490 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | TICAM1 | RHIM domain-containing protein. (519 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa) |
| | TM2D1 | TM2 domain containing 1. (230 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | UBE4B | Ubiquitination factor E4B. (1302 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | DDX47 | DEAD-box helicase 47; Belongs to the DEAD box helicase family. (462 aa) |
| | DAB2IP | DAB2 interacting protein. (1153 aa) |
| | MCL1 | Uncharacterized protein. (350 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (398 aa) |
| | CD27 | CD27 molecule. (260 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) |
| | SORT1 | Sortilin. (831 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | NOL3 | CARD domain-containing protein. (258 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) |
| | FAIM2 | Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (315 aa) |
| | RAI14 | Retinoic acid induced 14. (983 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | ENSMFAP00000025726 | Uncharacterized protein. (170 aa) |
| | ENSMFAP00000025734 | Uncharacterized protein. (72 aa) |
| | STK25 | Serine/threonine kinase 25. (426 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (421 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (733 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (990 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | PDCD10 | Programmed cell death protein 10. (212 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (377 aa) |
| | EPHA2 | Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa) |
| | ENSMFAP00000027666 | Uncharacterized protein. (65 aa) |
| | NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] (163 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | BRSK2 | BR serine/threonine kinase 2. (762 aa) |
| | UMOD | Uromodulin. (641 aa) |
| | DAP | Uncharacterized protein. (141 aa) |
| | CLU | Clusterin; Belongs to the clusterin family. (501 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | IFI16 | Interferon gamma inducible protein 16. (729 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (675 aa) |
| | LGALS12 | Galectin. (336 aa) |
| | MYBBP1A | MYB binding protein 1a. (1339 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3418 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1139 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
