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| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | BCL2L10 | Uncharacterized protein. (194 aa) |
| | BCL2A1 | BCL2 related protein A1. (175 aa) |
| | MOAP1 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity); Belongs to the PNMA family. (351 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | DEDD2 | Death effector domain containing 2. (326 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1594 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | TNFSF12 | TNF superfamily member 12; Belongs to the tumor necrosis factor family. (250 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (445 aa) |
| | PML | Promyelocytic leukemia. (882 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | ENSMFAP00000005981 | Uncharacterized protein. (471 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | RNF41 | Ring finger protein 41. (317 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | ENSMFAP00000009961 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | ENSMFAP00000010121 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | BCL2 | BCL2 apoptosis regulator. (242 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
| | ENSMFAP00000011344 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | ITPRIPL2 | ITPRIP like 2. (535 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (311 aa) |
| | ENSMFAP00000012338 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | G0S2 | G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. (103 aa) |
| | CTTN | Cortactin. (550 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | SKIL | SKI like proto-oncogene. (684 aa) |
| | ENSMFAP00000014001 | Uncharacterized protein. (91 aa) |
| | ENSMFAP00000014424 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa) |
| | STK4 | Serine/threonine kinase 4. (487 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (510 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1502 aa) |
| | PIDD1 | P53-induced death domain protein 1. (910 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (397 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (808 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | ENSMFAP00000020125 | IF rod domain-containing protein; Belongs to the intermediate filament family. (123 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | BAG3 | BCL2 associated athanogene 3. (575 aa) |
| | ENSMFAP00000022286 | Uncharacterized protein. (156 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | KRT18 | IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | CD27 | CD27 molecule. (260 aa) |
| | SORT1 | Sortilin. (831 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | BID | BH3 interacting domain death agonist. (244 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (377 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | TNFRSF1A | Uncharacterized protein. (455 aa) |
| | MCL1 | Uncharacterized protein. (350 aa) |
| | DAB2IP | DAB2 interacting protein. (1153 aa) |
| | DDX47 | DEAD-box helicase 47; Belongs to the DEAD box helicase family. (462 aa) |
| | CASP8AP2 | Caspase 8 associated protein 2. (1986 aa) |
| | IL33 | Interleukin 33. (270 aa) |
| | ENSMFAP00000031985 | Uncharacterized protein. (83 aa) |
| | YAP1 | Yes associated protein 1. (506 aa) |
| | MKNK2 | MAPK interacting serine/threonine kinase 2. (454 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | IFI27 | Interferon alpha inducible protein 27. (122 aa) |
| | DAPK1 | Death associated protein kinase 1. (1440 aa) |
| | STAMBPL1 | STAM binding protein like 1. (461 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa) |
| | BEX3 | Brain expressed X-linked 3. (123 aa) |
| | GABARAP | GABA type A receptor-associated protein. (117 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | JAK2 | Tyrosine-protein kinase. (1139 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | INHBA | Inhibin subunit beta A. (426 aa) |
| | IL6R | Interleukin 6 receptor. (468 aa) |
| | DAXX | Death domain associated protein. (740 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | NF1 | Neurofibromin 1. (2849 aa) |
| | CD70 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (316 aa) |
| | ENSMFAP00000040724 | IF rod domain-containing protein; Belongs to the intermediate filament family. (426 aa) |
| | CTNNA1 | Catenin alpha 1. (906 aa) |
| | DELE1 | DAP3 binding cell death enhancer 1. (522 aa) |
| | DEDD | Death effector domain containing. (347 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1353 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
