STRINGSTRING
STX3 STX3 FYN FYN CDH11 CDH11 EPHA7 EPHA7 EFNB2 EFNB2 GABBR1 GABBR1 INA INA NTNG1 NTNG1 TNR TNR ADCY8 ADCY8 CDK5 CDK5 DGKI DGKI CTNNB1 CTNNB1 GRM1 GRM1 PTPRS PTPRS ADORA2B ADORA2B ENSMFAP00000011456 ENSMFAP00000011456 MPP6 MPP6 CHRM1 CHRM1 LRRC4C LRRC4C ADRB1 ADRB1 SHANK1 SHANK1 APBA1 APBA1 PPP3R1 PPP3R1 NEFL NEFL CTNND1 CTNND1 PTPRD PTPRD FBXL20 FBXL20 DCC DCC DVL1 DVL1 CASK CASK BAIAP2 BAIAP2 PTPRA PTPRA GHRL GHRL NEFH NEFH PFN2 PFN2 BCR BCR ABR ABR P2RX3 P2RX3 WNT7A WNT7A PLAT PLAT SYN2 SYN2 LRFN2 LRFN2 DGKB DGKB BSN BSN GIPC1 GIPC1 DTNBP1 DTNBP1 ITPR1 ITPR1 SYN1 SYN1 NPTN NPTN EPHA4 EPHA4 PPP3CA PPP3CA GSG1L GSG1L CACNG2 CACNG2 GRM5 GRM5 SYP SYP MPP2 MPP2 PRKCZ PRKCZ ADCY1 ADCY1 IQSEC2 IQSEC2 CACNG3 CACNG3 NRXN1 NRXN1 GHSR GHSR GRASP GRASP ENSMFAP00000042030 ENSMFAP00000042030 AKAP12 AKAP12 LRRC4 LRRC4 NTNG2 NTNG2 LRRTM2 LRRTM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STX3Syntaxin 3; Belongs to the syntaxin family. (302 aa)
FYNTyrosine-protein kinase. (537 aa)
CDH11Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
EPHA7EPH receptor A7. (998 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1011 aa)
INAIF rod domain-containing protein; Belongs to the intermediate filament family. (499 aa)
NTNG1Netrin G1. (539 aa)
TNRTenascin R. (1358 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
DGKIDiacylglycerol kinase. (1079 aa)
CTNNB1Catenin beta 1. (781 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
ENSMFAP00000011456IF rod domain-containing protein; Belongs to the intermediate filament family. (427 aa)
MPP6Uncharacterized protein; Belongs to the MAGUK family. (582 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
ADRB1Adrenoceptor beta 1. (438 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2171 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (840 aa)
PPP3R1Uncharacterized protein. (189 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (543 aa)
CTNND1Catenin delta 1. (968 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1912 aa)
FBXL20F-box and leucine rich repeat protein 20. (406 aa)
DCCDCC netrin 1 receptor. (1447 aa)
DVL1Dishevelled segment polarity protein 1. (673 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
BAIAP2Uncharacterized protein. (552 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
NEFHNeurofilament heavy; Belongs to the intermediate filament family. (985 aa)
PFN2Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (188 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
ABRABR activator of RhoGEF and GTPase. (861 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (398 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
SYN2Synapsin II. (584 aa)
LRFN2Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). (808 aa)
DGKBDiacylglycerol kinase. (803 aa)
BSNBassoon presynaptic cytomatrix protein. (3938 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
DTNBP1Dystrobrevin binding protein 1. (350 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
SYN1Synapsin I. (705 aa)
NPTNNeuroplastin. (398 aa)
EPHA4EPH receptor A4. (986 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GSG1LGSG1 like. (330 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
SYPSynaptophysin. (313 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (537 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
IQSEC2IQ motif and Sec7 domain 2. (1433 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. (301 aa)
NRXN1Neurexin 1. (1507 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GRASPGeneral receptor for phosphoinositides 1 associated scaffold protein. (395 aa)
ENSMFAP00000042030Profilin; Belongs to the profilin family. (132 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
LRRC4Leucine rich repeat containing 4. (633 aa)
NTNG2Netrin G2. (530 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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