STRINGSTRING
DDC DDC AP2M1 AP2M1 SYNJ1 SYNJ1 ENSMFAP00000012353 ENSMFAP00000012353 STX11 STX11 PPFIA3 PPFIA3 LOC102136620 LOC102136620 BRAF BRAF SNAP47 SNAP47 ENSMFAP00000008168 ENSMFAP00000008168 PCLO PCLO PACSIN1 PACSIN1 CTNNB1 CTNNB1 CLSTN1 CLSTN1 STX1A STX1A BLOC1S6 BLOC1S6 VAMP1 VAMP1 AP3B2 AP3B2 DOC2B DOC2B ENSMFAP00000005493 ENSMFAP00000005493 CDK5 CDK5 SLC17A8 SLC17A8 SLC17A7 SLC17A7 SYNDIG1 SYNDIG1 SNAP25 SNAP25 DNAJC5 DNAJC5 ARF6 ARF6 SYT2 SYT2 DNM3 DNM3 SYNJ2 SYNJ2 CADPS2 CADPS2 SNCG SNCG PSEN1 PSEN1 SNCB SNCB ENSMFAP00000002252 ENSMFAP00000002252 ENSMFAP00000001834 ENSMFAP00000001834 NAPA NAPA ENSMFAP00000001080 ENSMFAP00000001080 STX3 STX3 NSG1 NSG1 SH3GL2 SH3GL2 OTOF OTOF SH3GL1 SH3GL1 ITSN1 ITSN1 STX2 STX2 DNAJC6 DNAJC6 PIP5K1C PIP5K1C STX4 STX4 CPLX3 CPLX3 AP3M2 AP3M2 WNT3A WNT3A SNAP91 SNAP91 ITSN2 ITSN2 SYN2 SYN2 SYT12 SYT12 ENSMFAP00000030029 ENSMFAP00000030029 SCRIB SCRIB AP2A1 AP2A1 TH TH NLGN2 NLGN2 RIMS3 RIMS3 NLGN1 NLGN1 SYN1 SYN1 RAB27B RAB27B SNAPIN SNAPIN SYT5 SYT5 UNC13A UNC13A UNC13C UNC13C BTBD8 BTBD8 PLD2 PLD2 AP3S1 AP3S1 UNC13B UNC13B SYT1 SYT1 BRSK1 BRSK1 SYT8 SYT8 CALY CALY SLC17A6 SLC17A6 PICALM PICALM RAP1A RAP1A RIMS1 RIMS1 SV2A SV2A SYP SYP CPLX2 CPLX2 CADPS CADPS SYT9 SYT9 SH3GL3 SH3GL3 NRXN1 NRXN1 CTBP2 CTBP2 GIT2 GIT2 DNM2 DNM2 ENSMFAP00000040574 ENSMFAP00000040574 OPHN1 OPHN1 VPS35 VPS35 SNAP23 SNAP23 LRRC1 LRRC1 AP3B1 AP3B1 CPLX4 CPLX4 GIT1 GIT1 SYNPR SYNPR STON2 STON2 AMPH AMPH AP2B1 AP2B1 AP3D1 AP3D1 GRIP2 GRIP2 ERC2 ERC2 GAK GAK SYT7 SYT7 PRRT2 PRRT2 P2RX7 P2RX7 STX1B STX1B SYN3 SYN3 ACTB ACTB NOSTRIN NOSTRIN BIN1 BIN1 CANX CANX AP2A2 AP2A2 DENND1A DENND1A SLC18A2 SLC18A2 DOC2A DOC2A RIMS2 RIMS2 DNM1 DNM1 FCHO2 FCHO2 KIAA1109 KIAA1109 LOC102127640 LOC102127640 SLC18A1 SLC18A1 ENSMFAP00000013586 ENSMFAP00000013586
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDCUncharacterized protein. (480 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
SYNJ1Synaptojanin 1. (1548 aa)
ENSMFAP00000012353Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (435 aa)
STX11Syntaxin 11; Belongs to the syntaxin family. (287 aa)
PPFIA3PTPRF interacting protein alpha 3. (1194 aa)
LOC102136620Uncharacterized protein. (64 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (762 aa)
SNAP47Synaptosome associated protein 47. (463 aa)
ENSMFAP00000008168Uncharacterized protein. (511 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5181 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
CTNNB1Catenin beta 1. (781 aa)
CLSTN1Calsyntenin 1. (974 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa)
VAMP1Vesicle associated membrane protein 1. (118 aa)
AP3B2AP-3 complex subunit beta. (1101 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
ENSMFAP00000005493COesterase domain-containing protein. (295 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SLC17A8Solute carrier family 17 member 8. (589 aa)
SLC17A7Solute carrier family 17 member 7. (561 aa)
SYNDIG1Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. (258 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
SYT2Synaptotagmin 2. (419 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
SYNJ2Synaptojanin 2. (1390 aa)
CADPS2Calcium dependent secretion activator 2. (1209 aa)
SNCGGamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity); Belongs to the synuclein family. (127 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
ENSMFAP00000002252UBA domain-containing protein. (444 aa)
ENSMFAP00000001834COesterase domain-containing protein. (221 aa)
NAPAAlpha-soluble NSF attachment protein. (295 aa)
ENSMFAP00000001080Uncharacterized protein; Belongs to the actin family. (354 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (302 aa)
NSG1Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (341 aa)
OTOFOtoferlin. (1997 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (320 aa)
ITSN1Intersectin 1. (1625 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (277 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (970 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (708 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (171 aa)
CPLX3Complexin 3. (158 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SNAP91Synaptosome associated protein 91. (907 aa)
ITSN2Intersectin 2. (1697 aa)
SYN2Synapsin II. (584 aa)
SYT12Synaptotagmin 12. (421 aa)
ENSMFAP00000030029BAR domain-containing protein. (320 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
THTyrosine hydroxylase. (529 aa)
NLGN2Neuroligin 2. (849 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
NLGN1Neuroligin 1. (823 aa)
SYN1Synapsin I. (705 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SYT5Brain cDNA, clone: QccE-17821, similar to human synaptotagmin V (SYT5). (386 aa)
UNC13AUnc-13 homolog A. (1592 aa)
UNC13CUnc-13 homolog C. (2216 aa)
BTBD8BTB domain containing 8. (1411 aa)
PLD2Phospholipase. (933 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
UNC13BUncharacterized protein. (4336 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (422 aa)
BRSK1Protein kinase domain-containing protein. (286 aa)
SYT8Synaptotagmin 8. (387 aa)
CALYCalcyon neuron specific vesicular protein. (217 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (686 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
SV2ASynaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). (742 aa)
SYPSynaptophysin. (313 aa)
CPLX2Uncharacterized protein. (134 aa)
CADPSCalcium dependent secretion activator. (1345 aa)
SYT9Synaptotagmin 9. (491 aa)
SH3GL3Uncharacterized protein. (354 aa)
NRXN1Neurexin 1. (1507 aa)
CTBP2C-terminal binding protein 2. (985 aa)
GIT2GIT ArfGAP 2. (760 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
ENSMFAP00000040574Uncharacterized protein. (130 aa)
OPHN1Oligophrenin 1. (802 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1063 aa)
CPLX4Complexin 4. (160 aa)
GIT1GIT ArfGAP 1. (776 aa)
SYNPRSynaptoporin. (285 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa)
AMPHAmphiphysin. (694 aa)
AP2B1AP complex subunit beta. (951 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1215 aa)
GRIP2Glutamate receptor interacting protein 2. (1143 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (957 aa)
GAKCyclin G associated kinase. (1311 aa)
SYT7Synaptotagmin 7. (686 aa)
PRRT2Proline rich transmembrane protein 2. (340 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
SYN3Synapsin III. (580 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
NOSTRINNitric oxide synthase trafficking. (562 aa)
BIN1Bridging integrator 1. (451 aa)
CANXCalnexin. (592 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (940 aa)
DENND1ADENN domain containing 1A. (915 aa)
SLC18A2Solute carrier family 18 member A2. (485 aa)
DOC2ADouble C2-like domain-containing protein. (400 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
FCHO2FCH domain only 2. (815 aa)
KIAA1109KIAA1109. (5058 aa)
LOC102127640Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (437 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
ENSMFAP00000013586Uncharacterized protein; Belongs to the actin family. (257 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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