STRINGSTRING
PHF10 PHF10 VPS72 VPS72 ENSMFAP00000001080 ENSMFAP00000001080 HELQ HELQ MRNIP MRNIP EPC1 EPC1 MBTD1 MBTD1 MEAF6 MEAF6 SIRT6 SIRT6 SPIRE1 SPIRE1 ENSMFAP00000004985 ENSMFAP00000004985 PARP1 PARP1 WAS WAS WRAP53 WRAP53 ENSMFAP00000007596 ENSMFAP00000007596 KMT5C KMT5C ENSMFAP00000007806 ENSMFAP00000007806 SMARCB1 SMARCB1 KAT5 KAT5 ENSMFAP00000009163 ENSMFAP00000009163 LOC102124821 LOC102124821 ENSMFAP00000012243 ENSMFAP00000012243 ENSMFAP00000012317 ENSMFAP00000012317 ENSMFAP00000012580 ENSMFAP00000012580 LOC102136325 LOC102136325 SLF1 SLF1 SETMAR SETMAR ENSMFAP00000013586 ENSMFAP00000013586 ENSMFAP00000014022 ENSMFAP00000014022 UBE2NL UBE2NL ACTL6A ACTL6A TIMELESS TIMELESS UBE2V2 UBE2V2 DMAP1 DMAP1 FOXM1 FOXM1 PARP9 PARP9 KMT5B KMT5B DTX3L DTX3L SMARCC2 SMARCC2 FUS FUS ACTB ACTB RBBP8 RBBP8 RIF1 RIF1 RUVBL2 RUVBL2 BCL7C BCL7C SMARCD3 SMARCD3 ARID1A ARID1A PARP3 PARP3 ENSMFAP00000019905 ENSMFAP00000019905 DPF3 DPF3 DDX11 DDX11 ERCC6 ERCC6 PRKDC PRKDC ARID1B ARID1B PBRM1 PBRM1 SMARCC1 SMARCC1 ENSMFAP00000022955 ENSMFAP00000022955 SMARCA4 SMARCA4 MORF4L2 MORF4L2 SPIDR SPIDR POGZ POGZ ZCWPW1 ZCWPW1 ACTR2 ACTR2 OOEP OOEP ENSMFAP00000025930 ENSMFAP00000025930 ING3 ING3 ENSMFAP00000026582 ENSMFAP00000026582 MMS19 MMS19 BCL7A BCL7A FH FH WDR48 WDR48 DPF1 DPF1 SMARCE1 SMARCE1 SLF2 SLF2 ENSMFAP00000030863 ENSMFAP00000030863 RAD51AP1 RAD51AP1 MGMT MGMT MRGBP MRGBP RUVBL1 RUVBL1 SHLD2 SHLD2 KHDC3L KHDC3L SHLD1 SHLD1 EPC2 EPC2 SMARCA2 SMARCA2 FANCB FANCB SMARCD2 SMARCD2 BCL7B BCL7B SMCHD1 SMCHD1 ARID2 ARID2 ACTL6B ACTL6B PIAS4 PIAS4 MAD2L2 MAD2L2 ENSMFAP00000040574 ENSMFAP00000040574 YEATS4 YEATS4 EP400 EP400 SPIRE2 SPIRE2 BRD8 BRD8 PNKP PNKP HDGFL2 HDGFL2 FMN2 FMN2 UBE2N UBE2N TRRAP TRRAP SMARCD1 SMARCD1 DPF2 DPF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHF10PHD finger protein 10. (469 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
ENSMFAP00000001080Uncharacterized protein; Belongs to the actin family. (354 aa)
HELQHelicase, POLQ like. (1101 aa)
MRNIPMRN complex interacting protein. (343 aa)
EPC1Enhancer of polycomb homolog. (836 aa)
MBTD1Mbt domain containing 1. (754 aa)
MEAF6MYST/Esa1 associated factor 6. (201 aa)
SIRT6Sirtuin 6. (355 aa)
SPIRE1Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in [...] (757 aa)
ENSMFAP00000004985Uncharacterized protein. (90 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
WASWASP actin nucleation promoting factor. (503 aa)
WRAP53WD repeat containing antisense to TP53. (548 aa)
ENSMFAP00000007596FAM35_C domain-containing protein. (223 aa)
KMT5CLysine methyltransferase 5C. (461 aa)
ENSMFAP00000007806EP400_N domain-containing protein. (401 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
ENSMFAP00000009163Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (410 aa)
LOC102124821UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa)
ENSMFAP00000012243UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
ENSMFAP00000012317Uncharacterized protein. (59 aa)
ENSMFAP00000012580DUF4502 domain-containing protein. (62 aa)
LOC102136325UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
ENSMFAP00000013586Uncharacterized protein; Belongs to the actin family. (257 aa)
ENSMFAP00000014022UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ACTL6AActin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] (429 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (155 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (612 aa)
FOXM1Forkhead box M1. (770 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (818 aa)
KMT5BLysine methyltransferase 5B. (885 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1270 aa)
FUSUncharacterized protein. (530 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (379 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (473 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (242 aa)
SMARCD3SWIB domain-containing protein. (483 aa)
ARID1AAT-rich interaction domain 1A. (2268 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
ENSMFAP00000019905UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (141 aa)
DPF3Double PHD fingers 3. (275 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1496 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ARID1BAT-rich interaction domain 1B. (2295 aa)
PBRM1Polybromo 1. (1725 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa)
ENSMFAP00000022955Uncharacterized protein. (223 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
MORF4L2Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (288 aa)
SPIDRScaffold protein involved in DNA repair. (815 aa)
POGZPogo transposable element derived with ZNF domain. (1418 aa)
ZCWPW1Zinc finger CW-type and PWWP domain containing 1. (649 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
OOEPOocyte expressed protein. (149 aa)
ENSMFAP00000025930MRG domain-containing protein. (246 aa)
ING3Inhibitor of growth protein. (418 aa)
ENSMFAP00000026582HMG box domain-containing protein. (177 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (223 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (510 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (714 aa)
DPF1Double PHD fingers 1. (424 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
ENSMFAP00000030863Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (313 aa)
RAD51AP1RAD51 associated protein 1. (352 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (238 aa)
MRGBPMRG domain binding protein. (204 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (445 aa)
SHLD2FAM35_C domain-containing protein. (991 aa)
KHDC3LKH domain containing 3 like, subcortical maternal complex member. (206 aa)
SHLD1Shieldin complex subunit 1. (269 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1569 aa)
FANCBFA complementation group B. (858 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (493 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (202 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa)
ARID2AT-rich interaction domain 2. (1815 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
PIAS4Protein inhibitor of activated STAT 4. (510 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
ENSMFAP00000040574Uncharacterized protein. (130 aa)
YEATS4YEATS domain containing 4. (227 aa)
EP400E1A binding protein p400. (3136 aa)
SPIRE2Spire type actin nucleation factor 2. (714 aa)
BRD8Bromodomain containing 8. (1235 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
HDGFL2HDGF like 2. (670 aa)
FMN2Formin 2. (1729 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
DPF2Double PHD fingers 2. (405 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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