(52 nodes) SCF ubiquitin ligase complex network (Macaca fascicularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBXO41	F-box protein 41. (875 aa)
	FBXO31	F-box protein 31. (639 aa)
	FBXO27	F-box only protein 27; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. (280 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	FBXW11	F-box and WD repeat domain containing 11. (542 aa)
	RBX1	RING-box protein 1. (108 aa)
	FLI1	Fli-1 proto-oncogene, ETS transcription factor. (453 aa)
	FBXO32	F-box protein 32. (355 aa)
	FBXO44	Uncharacterized protein. (255 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (786 aa)
	FBXO38	F-box protein 38. (1188 aa)
	FBXL7	F-box and leucine rich repeat protein 7. (491 aa)
	FBXL22	F-box and leucine rich repeat protein 22. (236 aa)
	ENSMFAP00000045746	Zf-rbx1 domain-containing protein. (93 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	FBXO4	F-box protein 4. (387 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (691 aa)
	FBXO45	F-box protein 45. (320 aa)
	FBXO18	Uncharacterized protein. (344 aa)
	ENSMFAP00000021359	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (93 aa)
	ENSMFAP00000020763	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (65 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (220 aa)
	SKP2	S-phase kinase associated protein 2. (424 aa)
	ZC3HC1	Zinc finger C3HC-type containing 1. (502 aa)
	FBXO2	F-box protein 2. (297 aa)
	NCBP3	Nuclear cap binding subunit 3. (617 aa)
	BTRC	Uncharacterized protein. (605 aa)
	LOC102132252	FBA domain-containing protein. (110 aa)
	FBXW5	F-box and WD repeat domain containing 5. (566 aa)
	ENSMFAP00000007435	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (108 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (702 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	TMEM183A	Uncharacterized protein. (376 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (300 aa)
	FBXO33	F-box protein 33. (555 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
	FBXO9	F-box protein 9. (457 aa)
	ENSMFAP00000025792	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
	FBXL3	F-box and leucine rich repeat protein 3. (428 aa)
	FBXO25	F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (367 aa)
	ENSMFAP00000028800	Uncharacterized protein. (321 aa)
	LRRC29	Leucine rich repeat containing 29. (221 aa)
	ENSMFAP00000030335	Uncharacterized protein; Belongs to the SKP1 family. (141 aa)
	FBXL12	F-box and leucine rich repeat protein 12. (326 aa)
	ENSMFAP00000031351	Uncharacterized protein; Belongs to the SKP1 family. (166 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (694 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (418 aa)
	FBXL21P	F-box domain-containing protein. (434 aa)
	FBXO42	F-box protein 42. (716 aa)
	ENSMFAP00000036888	Uncharacterized protein. (340 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CCNF	ENSMFAP00000010380	ENSMFAP00000044202	Uncharacterized protein.	Cyclin F; Belongs to the cyclin family.	0.553
BTRC	CUL1	ENSMFAP00000010380	ENSMFAP00000039912	Uncharacterized protein.	Cullin 1; Belongs to the cullin family.	0.999
BTRC	ENSMFAP00000030335	ENSMFAP00000010380	ENSMFAP00000030335	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.917
BTRC	ENSMFAP00000031351	ENSMFAP00000010380	ENSMFAP00000031351	Uncharacterized protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.917
BTRC	ENSMFAP00000045746	ENSMFAP00000010380	ENSMFAP00000045746	Uncharacterized protein.	Zf-rbx1 domain-containing protein.	0.932
BTRC	FBXO2	ENSMFAP00000010380	ENSMFAP00000013975	Uncharacterized protein.	F-box protein 2.	0.939
BTRC	FBXO4	ENSMFAP00000010380	ENSMFAP00000023852	Uncharacterized protein.	F-box protein 4.	0.915
BTRC	FBXW11	ENSMFAP00000010380	ENSMFAP00000042731	Uncharacterized protein.	F-box and WD repeat domain containing 11.	0.975
BTRC	FBXW7	ENSMFAP00000010380	ENSMFAP00000039581	Uncharacterized protein.	F-box and WD repeat domain containing 7.	0.948
BTRC	RBX1	ENSMFAP00000010380	ENSMFAP00000042809	Uncharacterized protein.	RING-box protein 1.	0.992
BTRC	SKP1	ENSMFAP00000010380	ENSMFAP00000043769	Uncharacterized protein.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.991
BTRC	SKP2	ENSMFAP00000010380	ENSMFAP00000014684	Uncharacterized protein.	S-phase kinase associated protein 2.	0.961
BTRC	USP47	ENSMFAP00000010380	ENSMFAP00000024118	Uncharacterized protein.	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family.	0.589
CCNF	BTRC	ENSMFAP00000044202	ENSMFAP00000010380	Cyclin F; Belongs to the cyclin family.	Uncharacterized protein.	0.553
CCNF	CKS1B	ENSMFAP00000044202	ENSMFAP00000004808	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.566
CCNF	CKS2	ENSMFAP00000044202	ENSMFAP00000024066	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.566
CCNF	CUL1	ENSMFAP00000044202	ENSMFAP00000039912	Cyclin F; Belongs to the cyclin family.	Cullin 1; Belongs to the cullin family.	0.921
CCNF	ENSMFAP00000007435	ENSMFAP00000044202	ENSMFAP00000007435	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.566
CCNF	ENSMFAP00000020763	ENSMFAP00000044202	ENSMFAP00000020763	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.566
CCNF	ENSMFAP00000021359	ENSMFAP00000044202	ENSMFAP00000021359	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.566

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