node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDP1 | MYSM1 | ENSMFAP00000041417 | ENSMFAP00000006063 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB. | Myb like, SWIRM and MPN domains 1. | 0.610 |
CDC5L | MIER1 | ENSMFAP00000009496 | ENSMFAP00000025146 | Cell division cycle 5 like. | MIER1 transcriptional regulator. | 0.521 |
CDC5L | MTA2 | ENSMFAP00000009496 | ENSMFAP00000029081 | Cell division cycle 5 like. | Metastasis associated 1 family member 2. | 0.516 |
CDC5L | ZZZ3 | ENSMFAP00000009496 | ENSMFAP00000023532 | Cell division cycle 5 like. | Uncharacterized protein. | 0.546 |
DNAJC1 | DNAJC2 | ENSMFAP00000035138 | ENSMFAP00000026650 | DnaJ heat shock protein family (Hsp40) member C1. | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] | 0.526 |
DNAJC1 | TADA2A | ENSMFAP00000035138 | ENSMFAP00000040392 | DnaJ heat shock protein family (Hsp40) member C1. | Transcriptional adapter. | 0.436 |
DNAJC2 | DNAJC1 | ENSMFAP00000026650 | ENSMFAP00000035138 | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] | DnaJ heat shock protein family (Hsp40) member C1. | 0.526 |
DNAJC2 | TADA2A | ENSMFAP00000026650 | ENSMFAP00000040392 | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] | Transcriptional adapter. | 0.436 |
EZH1 | EZH2 | ENSMFAP00000018149 | ENSMFAP00000043388 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | 0.873 |
EZH1 | SMARCA1 | ENSMFAP00000018149 | ENSMFAP00000005409 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. | 0.457 |
EZH1 | SMARCA5 | ENSMFAP00000018149 | ENSMFAP00000024439 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. | 0.457 |
EZH2 | EZH1 | ENSMFAP00000043388 | ENSMFAP00000018149 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | Enhancer of zeste 1 polycomb repressive complex 2 subunit. | 0.873 |
EZH2 | SMARCA1 | ENSMFAP00000043388 | ENSMFAP00000005409 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. | 0.457 |
EZH2 | SMARCA5 | ENSMFAP00000043388 | ENSMFAP00000024439 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is m [...] | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. | 0.726 |
MIER1 | CDC5L | ENSMFAP00000025146 | ENSMFAP00000009496 | MIER1 transcriptional regulator. | Cell division cycle 5 like. | 0.521 |
MIER1 | ZZZ3 | ENSMFAP00000025146 | ENSMFAP00000023532 | MIER1 transcriptional regulator. | Uncharacterized protein. | 0.537 |
MIER3 | ZZZ3 | ENSMFAP00000000077 | ENSMFAP00000023532 | Mesoderm induction early response protein 3; Transcriptional repressor. | Uncharacterized protein. | 0.405 |
MTA2 | CDC5L | ENSMFAP00000029081 | ENSMFAP00000009496 | Metastasis associated 1 family member 2. | Cell division cycle 5 like. | 0.516 |
MTA2 | MTA3 | ENSMFAP00000029081 | ENSMFAP00000037258 | Metastasis associated 1 family member 2. | Metastasis associated 1 family member 3. | 0.800 |
MTA2 | SMARCA5 | ENSMFAP00000029081 | ENSMFAP00000024439 | Metastasis associated 1 family member 2. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. | 0.409 |