STRINGSTRING
PEAK1 PEAK1 ERBB4 ERBB4 FER FER TP53RK TP53RK NTRK2 NTRK2 EPHA2 EPHA2 RYK RYK FLT3 FLT3 TYK2 TYK2 PTK7 PTK7 NTRK3 NTRK3 LYN LYN LTK LTK KDR KDR BTK BTK PTK6 PTK6 HCK HCK FLT1 FLT1 PRAG1 PRAG1 EPHB4 EPHB4 RET RET SYK SYK ALK ALK FGFR3 FGFR3 MERTK MERTK LCK LCK BMX BMX STYK1 STYK1 EPHA3 EPHA3 TNK1 TNK1 NTRK1 NTRK1 MATK MATK MET MET TESK1 TESK1 KIT KIT EPHA6 EPHA6 EPHB1 EPHB1 TEC TEC PTK2 PTK2 PDGFRB PDGFRB DDR2 DDR2 SRMS SRMS TESK2 TESK2 EPHA7 EPHA7 FGFR2 FGFR2 FYN FYN ABL1 ABL1 FLT4 FLT4 NEK10 NEK10 AXL AXL ERBB2 ERBB2 ROR1 ROR1 TNK2 TNK2 PDGFRA PDGFRA ITK ITK FRK FRK EPHA1 EPHA1 INSRR INSRR INSR INSR EGFR EGFR FGR FGR FGFR1 FGFR1 CSF1R CSF1R JAK3 JAK3 TYRO3 TYRO3 PTK2B PTK2B JAK2 JAK2 JAK1 JAK1 EPHB2 EPHB2 PLK4 PLK4 YES1 YES1 IGF1R IGF1R EPHA5 EPHA5 TIE1 TIE1 EPHA4 EPHA4 EPHB3 EPHB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PEAK1Pseudopodium enriched atypical kinase 1. (1746 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
TP53RKTP53 regulating kinase and related kinases. (253 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
EPHA2Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] (1036 aa)
RYKReceptor like tyrosine kinase. (585 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1028 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (866 aa)
LYNTyrosine-protein kinase. (512 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BTKTyrosine-protein kinase. (659 aa)
PTK6Tyrosine-protein kinase. (451 aa)
HCKTyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] (525 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
PRAG1PEAK1 related, kinase-activating pseudokinase 1. (1402 aa)
EPHB4EPH receptor B4. (987 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1117 aa)
SYKTyrosine-protein kinase. (635 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
MERTKMER proto-oncogene, tyrosine kinase. (1001 aa)
LCKTyrosine-protein kinase. (342 aa)
BMXTyrosine-protein kinase. (679 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
EPHA3EPH receptor A3. (984 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
MATKTyrosine-protein kinase. (535 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
EPHA6EPH receptor A6. (1131 aa)
EPHB1EPH receptor B1. (984 aa)
TECTyrosine-protein kinase. (630 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
SRMSTyrosine-protein kinase. (492 aa)
TESK2Testis associated actin remodelling kinase 2. (572 aa)
EPHA7EPH receptor A7. (998 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
FYNTyrosine-protein kinase. (537 aa)
ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase. (901 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
NEK10NIMA related kinase 10. (1171 aa)
AXLAXL receptor tyrosine kinase. (718 aa)
ERBB2Receptor protein-tyrosine kinase. (1406 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (923 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1069 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ITKTyrosine-protein kinase. (620 aa)
FRKTyrosine-protein kinase. (529 aa)
EPHA1EPH receptor A1. (978 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGRTyrosine-protein kinase. (529 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (991 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
TYRO3TYRO3 protein tyrosine kinase. (902 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
EPHB2Uncharacterized protein. (468 aa)
PLK4Polo like kinase 4. (970 aa)
YES1Tyrosine-protein kinase. (548 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
EPHA5EPH receptor A5. (1038 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
EPHA4EPH receptor A4. (986 aa)
EPHB3EPH receptor B3. (1008 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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