STRINGSTRING
GDF10 GDF10 BMP15 BMP15 GDF6 GDF6 LOC102144954 LOC102144954 GDF3 GDF3 BMP10 BMP10 GDF15 GDF15 GDF5 GDF5 ENSMFAP00000029266 ENSMFAP00000029266 BMP2 BMP2 INHBB INHBB INHBE INHBE BMP7 BMP7 MSTN MSTN TGFB3 TGFB3 BMP4 BMP4 BMP6 BMP6 INHA INHA LEFTY1 LEFTY1 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
GDF6Growth differentiation factor 6. (455 aa)
LOC102144954Left-right determination factor. (366 aa)
GDF3Growth differentiation factor 3. (364 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
GDF15Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling (By similarity). (308 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSMFAP00000029266TGF_BETA_2 domain-containing protein. (344 aa)
BMP2Bone morphogenetic protein 2. (544 aa)
INHBBInhibin subunit beta B. (360 aa)
INHBEInhibin subunit beta E. (351 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
LEFTY1Left-right determination factor. (366 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: very high (>100%) [HD]