STRINGSTRING
TOPORS TOPORS LNX1 LNX1 TRIM23 TRIM23 RNF166 RNF166 SH3RF3 SH3RF3 RNF14 RNF14 CHFR CHFR RNF31 RNF31 TRIM69 TRIM69 RNF212 RNF212 TRIM7 TRIM7 RNF39 RNF39 CBL CBL TRAF5 TRAF5 TRIM47 TRIM47 RNF144A RNF144A TRAF6 TRAF6 BFAR BFAR SHPRH SHPRH PML PML RNF213 RNF213 CUL9 CUL9 PCGF6 PCGF6 TRIM17 TRIM17 TRIM10 TRIM10 TRIM11 TRIM11 TRIM27 TRIM27 TRIM46 TRIM46 DTX3 DTX3 HLTF HLTF COP1 COP1 TRIM68 TRIM68 PEX10 PEX10 TRIM2 TRIM2 RNFT2 RNFT2 CBLC CBLC RNF5 RNF5 TRIM67 TRIM67 MKRN2 MKRN2 TRIM55 TRIM55 LONRF1 LONRF1 LONRF3 LONRF3 TRIM77 TRIM77 RNF144B RNF144B TRIM5 TRIM5 TRAF3 TRAF3 BIRC7 BIRC7 LNX2 LNX2 TRAF7 TRAF7 TRIM52 TRIM52 TRIM36 TRIM36 TRIM24 TRIM24 LOC102139163 LOC102139163 RNF141 RNF141 TRIM13 TRIM13 RBCK1 RBCK1 SH3RF2 SH3RF2 RNF185 RNF185 UBOX5 UBOX5 TRIM25 TRIM25 SCAF11 SCAF11 TRAF4 TRAF4 PEX2 PEX2 TRIM4 TRIM4 MID1 MID1 RNF125 RNF125 TRIM21 TRIM21 PHRF1 PHRF1 PCGF1 PCGF1 RNF40 RNF40 TRIM9 TRIM9 TRIM22 TRIM22 RNF17 RNF17 RNF207 RNF207 TRIM63 TRIM63 DTX3L DTX3L CBLB CBLB TRIM75P TRIM75P RAD18 RAD18 SH3RF1 SH3RF1 TRIM61 TRIM61 LOC102142530 LOC102142530 RNF113A RNF113A LOC102137622 LOC102137622 RNF182 RNF182 TRIM42 TRIM42 TRIM32 TRIM32 RAG1 RAG1 TRIM15 TRIM15 RNF187 RNF187 RNF151 RNF151 PDZRN3 PDZRN3 RNF224 RNF224 RNF41 RNF41 PCGF2 PCGF2 RNF2 RNF2 PCGF5 PCGF5 RNF20 RNF20 RNF212B RNF212B RNF146 RNF146 LONRF2 LONRF2 RNF10 RNF10 TRIM39 TRIM39 CBLL1 CBLL1 RNF8 RNF8 TRIM59 TRIM59 TRIM38 TRIM38 RNF180 RNF180 RC3H1 RC3H1 TRIM54 TRIM54 BMI1 BMI1 UHRF1 UHRF1 TRIML1 TRIML1 LOC102115028 LOC102115028
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOPORSTOP1 binding arginine/serine rich protein. (1047 aa)
LNX1Ligand of numb-protein X 1. (727 aa)
TRIM23Tripartite motif containing 23. (574 aa)
RNF166Ring finger protein 166. (237 aa)
SH3RF3SH3 domain containing ring finger 3. (882 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
CHFRCheckpoint with forkhead and ring finger domains. (641 aa)
RNF31Uncharacterized protein. (1072 aa)
TRIM69Tripartite motif containing 69. (499 aa)
RNF212Ring finger protein 212. (215 aa)
TRIM7Tripartite motif containing 7. (511 aa)
RNF39Ring finger protein 39. (420 aa)
CBLCbl proto-oncogene. (907 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
TRIM47Tripartite motif containing 47. (640 aa)
RNF144ARBR-type E3 ubiquitin transferase. (292 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
BFARBifunctional apoptosis regulator. (450 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1683 aa)
PMLPromyelocytic leukemia. (882 aa)
RNF213Ring finger protein 213. (5073 aa)
CUL9Cullin 9; Belongs to the cullin family. (2517 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
TRIM17Tripartite motif containing 17. (477 aa)
TRIM10Tripartite motif containing 10. (481 aa)
TRIM11Tripartite motif containing 11. (468 aa)
TRIM27Tripartite motif containing 27. (513 aa)
TRIM46Tripartite motif containing 46. (759 aa)
DTX3Deltex E3 ubiquitin ligase 3. (350 aa)
HLTFHelicase like transcription factor. (1013 aa)
COP1COP1 E3 ubiquitin ligase. (731 aa)
TRIM68Uncharacterized protein. (485 aa)
PEX10Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. (346 aa)
TRIM2Tripartite motif containing 2. (771 aa)
RNFT2Ring finger protein, transmembrane 2. (436 aa)
CBLCCbl proto-oncogene C. (474 aa)
RNF5Ring finger protein 5. (180 aa)
TRIM67Tripartite motif containing 67. (782 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
TRIM55Tripartite motif containing 55. (543 aa)
LONRF1LON peptidase N-terminal domain and ring finger 1. (675 aa)
LONRF3LON peptidase N-terminal domain and RING finger protein 3. (811 aa)
TRIM77Tripartite motif containing 77. (450 aa)
RNF144BRBR-type E3 ubiquitin transferase. (303 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (495 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
LNX2Ligand of numb-protein X 2. (690 aa)
TRAF7TNF receptor associated factor 7. (670 aa)
TRIM52Tripartite motif containing 52. (296 aa)
TRIM36Tripartite motif containing 36. (728 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
LOC102139163Uncharacterized protein. (449 aa)
RNF141Ring finger protein 141. (230 aa)
TRIM13Tripartite motif containing 13. (409 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
SH3RF2SH3 domain containing ring finger 2. (729 aa)
RNF185Ring finger protein 185. (192 aa)
UBOX5U-box domain containing 5. (541 aa)
TRIM25Tripartite motif containing 25. (630 aa)
SCAF11SR-related CTD associated factor 11. (1464 aa)
TRAF4TNF receptor-associated factor. (470 aa)
PEX2Peroxisomal biogenesis factor 2. (323 aa)
TRIM4Tripartite motif containing 4. (474 aa)
MID1Midline 1. (667 aa)
RNF125E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. (232 aa)
TRIM21Tripartite motif containing 21. (475 aa)
PHRF1PHD and ring finger domains 1. (1644 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
RNF40E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] (1001 aa)
TRIM9Tripartite motif containing 9. (795 aa)
TRIM22Tripartite motif containing 22. (498 aa)
RNF17RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). (1624 aa)
RNF207Ring finger protein 207. (634 aa)
TRIM63Tripartite motif containing 63. (383 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (740 aa)
CBLBCbl proto-oncogene B. (982 aa)
TRIM75PTripartite motif containing 75, pseudogene. (468 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
SH3RF1SH3 domain containing ring finger 1. (890 aa)
TRIM61Tripartite motif containing 61. (209 aa)
LOC102142530Uncharacterized protein. (488 aa)
RNF113ARing finger protein 113A. (344 aa)
LOC102137622Uncharacterized protein. (503 aa)
RNF182Ring finger protein 182. (247 aa)
TRIM42Tripartite motif containing 42. (723 aa)
TRIM32Tripartite motif containing 32. (653 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
TRIM15Tripartite motif containing 15. (465 aa)
RNF187Ring finger protein 187. (237 aa)
RNF151Ring finger protein 151. (245 aa)
PDZRN3PDZ domain containing ring finger 3. (1066 aa)
RNF224Ring finger protein 224. (153 aa)
RNF41Ring finger protein 41. (317 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
RNF2Ring finger protein 2. (336 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
RNF212BRing finger protein 212B. (300 aa)
RNF146E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (360 aa)
LONRF2LON peptidase N-terminal domain and ring finger 2. (754 aa)
RNF10Ring finger protein 10. (811 aa)
TRIM39Tripartite motif containing 39. (518 aa)
CBLL1E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6- methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown; Belongs to the Hakai family. (491 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
TRIM59Uncharacterized protein. (323 aa)
TRIM38Tripartite motif containing 38. (465 aa)
RNF180Ring finger protein 180. (592 aa)
RC3H1Ring finger and CCCH-type domains 1. (1141 aa)
TRIM54Tripartite motif containing 54. (402 aa)
BMI1RING-type domain-containing protein. (326 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (859 aa)
TRIML1Tripartite motif family like 1. (468 aa)
LOC102115028Uncharacterized protein. (449 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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