STRINGSTRING
ATAT1 ATAT1 KAT2A KAT2A ACAA2 ACAA2 PDHX PDHX ZDHHC19 ZDHHC19 ZDHHC12 ZDHHC12 CRAT CRAT ZDHHC4 ZDHHC4 ZDHHC23 ZDHHC23 ENSMFAP00000006765 ENSMFAP00000006765 NAT10 NAT10 ZDHHC3 ZDHHC3 ZDHHC24 ZDHHC24 ELP3 ELP3 GTF2B GTF2B PIGW PIGW CROT CROT QPCTL QPCTL I7G8M4_MACFA I7G8M4_MACFA CPT1B CPT1B SPTLC1 SPTLC1 DLAT DLAT ZDHHC18 ZDHHC18 HADHB HADHB ZDHHC5 ZDHHC5 OSGEPL1 OSGEPL1 ZDHHC22 ZDHHC22 CPT1A CPT1A GPAM GPAM KAT6B KAT6B SOAT2 SOAT2 GNPAT GNPAT ACAT2 ACAT2 CPT2 CPT2 NMT1 NMT1 ATE1 ATE1 ZDHHC13 ZDHHC13 ACAA1 ACAA1 NAT1 NAT1 HAT1 HAT1 OXSM OXSM ACAT1 ACAT1 GNPNAT1 GNPNAT1 ZDHHC8 ZDHHC8 DBT DBT CHAT CHAT OSGEP OSGEP ZDHHC14 ZDHHC14 ZDHHC6 ZDHHC6 AGPAT4 AGPAT4 NAA20 NAA20 ZDHHC20 ZDHHC20 ZDHHC17 ZDHHC17 AGPAT1 AGPAT1 ZDHHC7 ZDHHC7 ZDHHC2 ZDHHC2 SOAT1 SOAT1 ZDHHC9 ZDHHC9 ALAS2 ALAS2 DGAT1 DGAT1 AGPAT2 AGPAT2 CREBBP CREBBP ALAS1 ALAS1 ZDHHC1 ZDHHC1 LIPT2 LIPT2 ZDHHC21 ZDHHC21 ZDHHC16 ZDHHC16 ENSMFAP00000039004 ENSMFAP00000039004 ZDHHC15 ZDHHC15 SCP2 SCP2 ENSMFAP00000043638 ENSMFAP00000043638 CPT1C CPT1C NMT2 NMT2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (413 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
ZDHHC19Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (309 aa)
ZDHHC12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (267 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
ZDHHC4Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (344 aa)
ZDHHC23Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (433 aa)
ENSMFAP00000006765Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (503 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
ZDHHC3Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (357 aa)
ZDHHC24Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (284 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (547 aa)
GTF2BTranscription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II- TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter [...] (316 aa)
PIGWPhosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (504 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
QPCTLGlutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. Belongs to the glutaminyl-peptide cyclotransferase family. (382 aa)
I7G8M4_MACFAannotation not available (63 aa)
CPT1BUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
SPTLC1Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] (500 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ZDHHC18Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (253 aa)
HADHBTrifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] (479 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
OSGEPL1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
ZDHHC22Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (263 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
KAT6BHistone acetyltransferase KAT6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2- dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity; Belongs to the MYST (SAS/MOZ) family. (2071 aa)
SOAT2O-acyltransferase. (526 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (683 aa)
ACAT2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
CPT2Carnitine O-palmitoyltransferase 2, mitochondrial. (696 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
ATE1Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity); Belongs to the R-transferase family. (516 aa)
ZDHHC13Palmitoyltransferase ZDHHC13; Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. (622 aa)
ACAA1Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
NAT1N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family. (352 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
OXSM3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
ACAT1Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (459 aa)
GNPNAT1Glucosamine 6-phosphate N-acetyltransferase. (184 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (778 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (631 aa)
OSGEPProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa)
ZDHHC14Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (488 aa)
ZDHHC6Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). (378 aa)
NAA20N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. (178 aa)
ZDHHC20Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (365 aa)
ZDHHC17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (336 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
SOAT1Sterol O-acyltransferase 1; Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. (550 aa)
ZDHHC9Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (364 aa)
ALAS25-aminolevulinate synthase. (587 aa)
DGAT1O-acyltransferase. (491 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
CREBBPCREB binding protein. (2442 aa)
ALAS15-aminolevulinate synthase. (640 aa)
ZDHHC1Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (486 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ZDHHC16Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regu [...] (379 aa)
ENSMFAP00000039004Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (436 aa)
ZDHHC15Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (341 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
ENSMFAP00000043638Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (393 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
NMT2Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (498 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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