STRINGSTRING
ENSMFAP00000012290 ENSMFAP00000012290 RAD18 RAD18 LOC102117118 LOC102117118 RFC4 RFC4 POLE3 POLE3 ENSMFAP00000015231 ENSMFAP00000015231 ENSMFAP00000015936 ENSMFAP00000015936 USP1 USP1 CUL4A CUL4A RFC5 RFC5 KXD1 KXD1 RCBTB1 RCBTB1 DTL DTL WDR48 WDR48 RFC3 RFC3 ENSMFAP00000044257 ENSMFAP00000044257 ENSMFAP00000045746 ENSMFAP00000045746 MEIOB MEIOB POLD2 POLD2 CUL4B CUL4B DDB1 DDB1 RPA3 RPA3 RFC1 RFC1 RCBTB2 RCBTB2 PCNA PCNA RPS27A RPS27A POLE4 POLE4 RFC2 RFC2 POLD4 POLD4 UBB UBB RBX1 RBX1 POLE POLE POLD3 POLD3 ENSMFAP00000004513 ENSMFAP00000004513 ENSMFAP00000005841 ENSMFAP00000005841 POLE2 POLE2 ENSMFAP00000007027 ENSMFAP00000007027 ATAD5 ATAD5 ENSMFAP00000007997 ENSMFAP00000007997 RPA1 RPA1 ENSMFAP00000009883 ENSMFAP00000009883 POLD1 POLD1 UBC UBC LOC101864869 LOC101864869 ENSMFAP00000011880 ENSMFAP00000011880
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMFAP00000012290Ubiquitin-like domain-containing protein. (156 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
LOC102117118Ubiquitin-like domain-containing protein. (127 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
ENSMFAP00000015936Ubiquitin-like domain-containing protein. (144 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
RFC5Replication factor C subunit 5. (343 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (714 aa)
RFC3Replication factor C subunit 3/5. (356 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
ENSMFAP00000045746Zf-rbx1 domain-containing protein. (93 aa)
MEIOBMeiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa)
POLD2Uncharacterized protein. (504 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
RPA3Uncharacterized protein. (121 aa)
RFC1Replication factor C subunit 1. (1148 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
RPS27ABrain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLD4Uncharacterized protein. (107 aa)
UBBUncharacterized protein. (219 aa)
RBX1RING-box protein 1. (108 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (370 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
ENSMFAP00000005841Ubiquitin-like domain-containing protein. (122 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (533 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
ATAD5ATPase family AAA domain containing 5. (1820 aa)
ENSMFAP00000007997DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (189 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
ENSMFAP00000009883Ubiquitin-like domain-containing protein. (147 aa)
POLD1DNA polymerase. (1107 aa)
UBCUbiquitin C. (645 aa)
LOC101864869Ubiquitin-like domain-containing protein. (156 aa)
ENSMFAP00000011880Ubiquitin-like domain-containing protein. (128 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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