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MAPK1 MAPK1 PDE4C PDE4C GNB4 GNB4 GNA11 GNA11 PPP2R1B PPP2R1B PDE1C PDE1C ENSMFAP00000039407 ENSMFAP00000039407 ADCY3 ADCY3 ADCY1 ADCY1 ADCY7 ADCY7 GNAI3 GNAI3 GNG2 GNG2 PDE1A PDE1A LRBA LRBA PPP2CA PPP2CA GNAQ GNAQ GNG7 GNG7 PPP3CA PPP3CA CAMK2B CAMK2B GNB5 GNB5 ADCY5 ADCY5 PRKAR1B PRKAR1B PLCB2 PLCB2 CAMK4 CAMK4 ITPR1 ITPR1 PRKCG PRKCG ENSMFAP00000029969 ENSMFAP00000029969 PDE4D PDE4D PPP1R1B PPP1R1B PRKAR2A PRKAR2A ENSMFAP00000028378 ENSMFAP00000028378 CAMKK2 CAMKK2 THAP6 THAP6 PLCB3 PLCB3 CNBD2 CNBD2 AHCYL1 AHCYL1 GNG8 GNG8 GNAL GNAL PRKACB PRKACB PLA2G4A PLA2G4A PDYN PDYN PLCB1 PLCB1 GNG12 GNG12 CAMK2A CAMK2A GNA14 GNA14 ENSMFAP00000022223 ENSMFAP00000022223 ITPR2 ITPR2 GNG11 GNG11 PDE1B PDE1B ENSMFAP00000020180 ENSMFAP00000020180 PPP3CB PPP3CB GNAI2 GNAI2 PPP3R1 PPP3R1 PRKAR1A PRKAR1A CAMKK1 CAMKK1 PRKACG PRKACG GNG5 GNG5 DCLK1 DCLK1 GNB3 GNB3 ENSMFAP00000013772 ENSMFAP00000013772 PRKCA PRKCA LOC102126330 LOC102126330 NBEA NBEA PPP3CC PPP3CC PDE4A PDE4A PRKACA PRKACA GNGT2 GNGT2 GNAT3 GNAT3 GNAI1 GNAI1 PDE4B PDE4B CAMK2D CAMK2D PRKX PRKX GNG4 GNG4 ENSMFAP00000006047 ENSMFAP00000006047 OPRM1 OPRM1 GRK2 GRK2 THAP7 THAP7 ENSMFAP00000005412 ENSMFAP00000005412 CDK5 CDK5 GNG13 GNG13 PPP1CA PPP1CA ADCY2 ADCY2 ADCY8 ADCY8 PPP2R1A PPP2R1A GNGT1 GNGT1 ADCY6 ADCY6 PLCB4 PLCB4 KPNA2 KPNA2 ENSMFAP00000000823 ENSMFAP00000000823 PTRHD1 PTRHD1 GNA15 GNA15 POMC POMC PRKCD PRKCD PPP2CB PPP2CB ADCY4 ADCY4 CREB1 CREB1 GNG3 GNG3 GNB2 GNB2 ENSMFAP00000042978 ENSMFAP00000042978 PPP2R5D PPP2R5D GNB1 GNB1 ITPR3 ITPR3 GNG10 GNG10 PRKAR2B PRKAR2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PDE4CPhosphodiesterase. (712 aa)
GNB4G protein subunit beta 4. (340 aa)
GNA11G protein subunit alpha 11. (359 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
PDE1CPhosphodiesterase. (768 aa)
ENSMFAP00000039407Importin subunit alpha; Functions in nuclear protein import. (446 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PDE1APhosphodiesterase. (545 aa)
LRBALPS responsive beige-like anchor protein. (2852 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GNAQG protein subunit alpha q. (359 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (644 aa)
GNB5G protein subunit beta 5. (409 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (313 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
PRKCGProtein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (698 aa)
ENSMFAP00000029969Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
PDE4DPhosphodiesterase. (809 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (401 aa)
ENSMFAP00000028378Uncharacterized protein. (317 aa)
CAMKK2Protein kinase domain-containing protein. (582 aa)
THAP6THAP domain containing 6. (222 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
CNBD2Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. (581 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNALG protein subunit alpha L. (450 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PLA2G4APhospholipase A2. (749 aa)
PDYNProdynorphin. (253 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GNA14G protein subunit alpha 14. (355 aa)
ENSMFAP00000022223Cyclic nucleotide-binding domain-containing protein. (81 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PDE1BPhosphodiesterase. (538 aa)
ENSMFAP00000020180Uncharacterized protein. (375 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
PPP3R1Uncharacterized protein. (189 aa)
PRKAR1AUncharacterized protein. (381 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (333 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
GNB3G protein subunit beta 3. (340 aa)
ENSMFAP00000013772Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LOC102126330Importin subunit alpha; Functions in nuclear protein import. (504 aa)
NBEANeurobeachin. (2946 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
PDE4APhosphodiesterase. (832 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PDE4BPhosphodiesterase. (736 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (358 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSMFAP00000006047Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (455 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (674 aa)
THAP7THAP domain containing 7. (309 aa)
ENSMFAP00000005412Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
ENSMFAP00000000823G protein gamma domain-containing protein. (73 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
GNA15G protein subunit alpha 15. (330 aa)
POMCProopiomelanocortin. (265 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB2WD_REPEATS_REGION domain-containing protein. (375 aa)
ENSMFAP00000042978G protein gamma domain-containing protein. (63 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
GNB1G protein subunit beta 1. (340 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (421 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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