STRINGSTRING
LIN37 LIN37 CCNE2 CCNE2 ENSMFAP00000000647 ENSMFAP00000000647 ENSMFAP00000001828 ENSMFAP00000001828 E2F4 E2F4 MAX MAX ENSMFAP00000004513 ENSMFAP00000004513 TOP2A TOP2A LIN9 LIN9 HDAC1 HDAC1 ENSMFAP00000044019 ENSMFAP00000044019 CDK1 CDK1 ENSMFAP00000043974 ENSMFAP00000043974 RBBP4 RBBP4 RBL2 RBL2 DYRK1B DYRK1B MYC MYC TFDP2 TFDP2 ENSMFAP00000042484 ENSMFAP00000042484 CCNE1 CCNE1 ENSMFAP00000037272 ENSMFAP00000037272 CCNA2 CCNA2 LIN52 LIN52 PCNA PCNA E2F1 E2F1 ENSMFAP00000027449 ENSMFAP00000027449 CDC25A CDC25A CDK2 CDK2 ENSMFAP00000026376 ENSMFAP00000026376 CDC6 CDC6 ENSMFAP00000025317 ENSMFAP00000025317 ENSMFAP00000024220 ENSMFAP00000024220 ENSMFAP00000023399 ENSMFAP00000023399 CCNA1 CCNA1 DYRK1A DYRK1A TFDP1 TFDP1 TESMIN TESMIN MYBL2 MYBL2 CDK3 CDK3 LIN54 LIN54 TFDP3 TFDP3 ENSMFAP00000015144 ENSMFAP00000015144 RBL1 RBL1 LOC102142638 LOC102142638 ENSMFAP00000010148 ENSMFAP00000010148
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ENSMFAP00000000647WD_REPEATS_REGION domain-containing protein. (410 aa)
ENSMFAP00000001828CAF1C_H4-bd domain-containing protein. (103 aa)
E2F4E2F transcription factor 4. (416 aa)
MAXBHLH domain-containing protein. (160 aa)
ENSMFAP00000004513Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
LIN9Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity). (613 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSMFAP00000044019WD_REPEATS_REGION domain-containing protein. (237 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (425 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
TFDP2Transcription factor. (447 aa)
ENSMFAP00000042484CAF1C_H4-bd domain-containing protein. (69 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ENSMFAP00000037272Uncharacterized protein. (92 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
PCNAProliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa)
E2F1E2F transcription factor 1. (437 aa)
ENSMFAP00000027449WD_REPEATS_REGION domain-containing protein. (261 aa)
CDC25ACell division cycle 25A. (491 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSMFAP00000026376WD_REPEATS_REGION domain-containing protein. (381 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
ENSMFAP00000024220WD_REPEATS_REGION domain-containing protein. (398 aa)
ENSMFAP00000023399Uncharacterized protein. (88 aa)
CCNA1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (465 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
TFDP1Transcription factor. (410 aa)
TESMINTestis expressed metallothionein like protein. (508 aa)
MYBL2MYB proto-oncogene like 2. (700 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
TFDP3Transcription factor. (406 aa)
ENSMFAP00000015144Uncharacterized protein. (97 aa)
RBL1RB transcriptional corepressor like 1. (1067 aa)
LOC102142638Protein kinase domain-containing protein. (297 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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