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| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa) |
| | PELI2 | Pellino E3 ubiquitin protein ligase family member 2. (394 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (1044 aa) |
| | ENSMFAP00000001898 | Uncharacterized protein. (182 aa) |
| | ENSMFAP00000005841 | Ubiquitin-like domain-containing protein. (122 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (662 aa) |
| | LRRC71 | Leucine rich repeat containing 71. (559 aa) |
| | ATF1 | Activating transcription factor 1. (270 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | ALPK1 | Alpha kinase 1. (1244 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (403 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (474 aa) |
| | NLRP13 | NLR family pyrin domain containing 13. (1044 aa) |
| | ENSMFAP00000004421 | CCHC NOA-type domain-containing protein. (361 aa) |
| | ENSMFAP00000004424 | Uncharacterized protein. (182 aa) |
| | NLRX1 | NLR family member X1. (972 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. (192 aa) |
| | LY96 | MD2 protein. (160 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (421 aa) |
| | TLR8 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1058 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (464 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa) |
| | KHNYN | KH and NYN domain containing. (678 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (800 aa) |
| | LOC102116023 | Mitogen-activated protein kinase kinase kinase 8. (174 aa) |
| | ENSMFAP00000009791 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa) |
| | ENSMFAP00000009883 | Ubiquitin-like domain-containing protein. (147 aa) |
| | BTRC | Uncharacterized protein. (605 aa) |
| | UBC | Ubiquitin C. (645 aa) |
| | LOC101864869 | Ubiquitin-like domain-containing protein. (156 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (132 aa) |
| | LOC102124821 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1375 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1683 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | ENSMFAP00000011401 | ETS domain-containing protein. (426 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | TICAM2 | TIR domain-containing adaptor molecule 2. (235 aa) |
| | ENSMFAP00000011880 | Ubiquitin-like domain-containing protein. (128 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | ENSMFAP00000012290 | Ubiquitin-like domain-containing protein. (156 aa) |
| | SAA1 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | N4BP1 | NEDD4 binding protein 1. (896 aa) |
| | CD14 | Uncharacterized protein. (384 aa) |
| | LOC102136325 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa) |
| | LOC102139221 | WRNPLPNID domain-containing protein. (1042 aa) |
| | ENSMFAP00000013287 | TNF receptor-associated factor. (474 aa) |
| | ENSMFAP00000013596 | ETS domain-containing protein. (411 aa) |
| | LOC102117118 | Ubiquitin-like domain-containing protein. (127 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (185 aa) |
| | ENSMFAP00000014022 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (152 aa) |
| | ENSMFAP00000015310 | Uncharacterized protein. (304 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (221 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (899 aa) |
| | ENSMFAP00000015936 | Ubiquitin-like domain-containing protein. (144 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (872 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | LOC102117157 | Uncharacterized protein. (825 aa) |
| | NKIRAS2 | Uncharacterized protein. (228 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (760 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | NLRC5 | NLR family CARD domain containing 5. (1866 aa) |
| | ENSMFAP00000019905 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (141 aa) |
| | S100A12 | S100 calcium binding protein A12. (76 aa) |
| | S100B | S_100 domain-containing protein; Belongs to the S-100 family. (94 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (381 aa) |
| | LRRC14 | Uncharacterized protein. (493 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (326 aa) |
| | CREM | cAMP responsive element modulator. (330 aa) |
| | ENSMFAP00000026136 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | ENSMFAP00000027412 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (308 aa) |
| | FNBP4 | Formin binding protein 4. (1016 aa) |
| | TLR7 | Toll-like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa) |
| | MEF2A | Myocyte enhancer factor 2A. (509 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (322 aa) |
| | ENSMFAP00000030335 | Uncharacterized protein; Belongs to the SKP1 family. (141 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (398 aa) |
| | ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity); Belongs to the ECSIT family. (432 aa) |
| | TICAM1 | RHIM domain-containing protein. (519 aa) |
| | ENSMFAP00000031351 | Uncharacterized protein; Belongs to the SKP1 family. (166 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (657 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | LRRC31 | Leucine rich repeat containing 31. (578 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (429 aa) |
| | VRK3 | VRK serine/threonine kinase 3. (476 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (538 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1117 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa) |
| | RPS27A | Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | SAA4 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa) |
| | PPP4R1 | Protein phosphatase 4 regulatory subunit 1. (930 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (488 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (670 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | UBB | Uncharacterized protein. (219 aa) |
| | IRF7 | Interferon regulatory factor 7. (504 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | ELK1 | ETS domain-containing protein Elk-1. (428 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | ENSMFAP00000042558 | Uncharacterized protein. (170 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (542 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | DUSP7 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa) |
| | LOC102144128 | TIR domain-containing protein. (1033 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (836 aa) |
| | DUSP3 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | ENSMFAP00000045157 | Uncharacterized protein. (205 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
