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| | MIB2 | Mindbomb E3 ubiquitin protein ligase 2. (1070 aa) |
| | HDAC10 | Histone deacetylase 10. (672 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (467 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa) |
| | DLK1 | Delta like non-canonical Notch ligand 1. (383 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | HDAC11 | Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (319 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
| | ENSMFAP00000045746 | Zf-rbx1 domain-containing protein. (93 aa) |
| | ENSMFAP00000045669 | SKIP_SNW domain-containing protein. (467 aa) |
| | MAMLD1 | Mastermind like domain containing 1. (1006 aa) |
| | APH1B | Uncharacterized protein. (257 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (824 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | RBX1 | RING-box protein 1. (108 aa) |
| | DTX4 | Deltex E3 ubiquitin ligase 4. (619 aa) |
| | UBB | Uncharacterized protein. (219 aa) |
| | NUMB | NUMB endocytic adaptor protein. (652 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (707 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa) |
| | RPS27A | Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa) |
| | NCOR1 | Nuclear receptor corepressor 1. (2442 aa) |
| | DNER | Delta/notch like EGF repeat containing. (709 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | LRBA | LPS responsive beige-like anchor protein. (2852 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (782 aa) |
| | ADAM10 | ADAM metallopeptidase domain 10. (748 aa) |
| | NCSTN | Ncstrn_small domain-containing protein. (721 aa) |
| | DTX1 | Deltex E3 ubiquitin ligase 1. (535 aa) |
| | HDAC8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa) |
| | CDK8 | Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa) |
| | DTX2 | Deltex E3 ubiquitin ligase 2. (622 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | ARRB1 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] (473 aa) |
| | ENSMFAP00000031351 | Uncharacterized protein; Belongs to the SKP1 family. (166 aa) |
| | ENSMFAP00000030335 | Uncharacterized protein; Belongs to the SKP1 family. (141 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (862 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (328 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (555 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa) |
| | MIB1 | Mindbomb E3 ubiquitin protein ligase 1. (1006 aa) |
| | HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (788 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | HDAC6 | Histone deacetylase 6. (1215 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa) |
| | CNTN1 | Contactin 1. (1018 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (731 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | HIF1A | Uncharacterized protein. (831 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (805 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (337 aa) |
| | MAML2 | Mastermind like transcriptional coactivator 2. (1151 aa) |
| | ENSMFAP00000015936 | Ubiquitin-like domain-containing protein. (144 aa) |
| | CCNC | Cyclin C; Belongs to the cyclin family. (283 aa) |
| | LOC102117118 | Ubiquitin-like domain-containing protein. (127 aa) |
| | ENSMFAP00000012453 | Hist_deacetyl domain-containing protein. (223 aa) |
| | ENSMFAP00000012290 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSMFAP00000011880 | Ubiquitin-like domain-containing protein. (128 aa) |
| | HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa) |
| | LOC101864869 | Ubiquitin-like domain-containing protein. (156 aa) |
| | UBC | Ubiquitin C. (645 aa) |
| | TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (543 aa) |
| | NBEA | Neurobeachin. (2946 aa) |
| | TBL1X | F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | ENSMFAP00000009883 | Ubiquitin-like domain-containing protein. (147 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (574 aa) |
| | ARRB2 | Arrestin beta 2. (454 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (736 aa) |
| | APH1A | Uncharacterized protein. (265 aa) |
| | PSENEN | Presenilin enhancer, gamma-secretase subunit. (101 aa) |
| | ENSMFAP00000005841 | Ubiquitin-like domain-containing protein. (122 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2510 aa) |
| | RBPJ | Recombination signal binding protein for immunoglobulin kappa J region. (529 aa) |
| | HES4 | Hes family bHLH transcription factor 4. (225 aa) |
