STRINGSTRING
STAT3 STAT3 HDAC3 HDAC3 PIK3CB PIK3CB SIN3A SIN3A ENSMFAP00000008565 ENSMFAP00000008565 HDAC1 HDAC1 ROS1 ROS1 MDK MDK ENSMFAP00000010148 ENSMFAP00000010148 ENSMFAP00000012453 ENSMFAP00000012453 SRC SRC HIF1A HIF1A PTPRZ1 PTPRZ1 MYCN MYCN ALK ALK PTPN6 PTPN6 FRS2 FRS2 LTK LTK IL2RG IL2RG ENSMFAP00000025317 ENSMFAP00000025317 PTN PTN SHC1 SHC1 PIK3CA PIK3CA PIK3R1 PIK3R1 JAK3 JAK3 HDAC2 HDAC2 PIK3R2 PIK3R2 PRDM1 PRDM1 IRS1 IRS1 MYC MYC ENSMFAP00000043974 ENSMFAP00000043974 EP300 EP300 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (802 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1072 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ENSMFAP00000008565PID domain-containing protein. (467 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ROS1Tyrosine-protein kinase receptor. (2340 aa)
MDKMidkine. (143 aa)
ENSMFAP00000010148Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
SRCTyrosine-protein kinase. (542 aa)
HIF1AUncharacterized protein. (831 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2319 aa)
MYCNMYCN proto-oncogene, bHLH transcription factor. (464 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
ENSMFAP00000025317Hist_deacetyl domain-containing protein. (258 aa)
PTNPleiotrophin. (172 aa)
SHC1SHC adaptor protein 1. (584 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PIK3R2Uncharacterized protein. (694 aa)
PRDM1PR/SET domain 1. (825 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ENSMFAP00000043974Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
EP300E1A binding protein p300. (2414 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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