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| | PSMA7 | Proteasome subunit alpha type-7-like; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removi [...] (248 aa) |
| | ZBTB44 | Zinc finger and BTB domain containing 44. (570 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (718 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | SOX5 | SRY-box transcription factor 5. (763 aa) |
| | AXIN2 | Axin 2. (844 aa) |
| | ENSMFAP00000001505 | Histone H2A; Belongs to the histone H2A family. (126 aa) |
| | ENSMFAP00000001720 | AAA domain-containing protein; Belongs to the AAA ATPase family. (384 aa) |
| | LOC102121517 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa) |
| | LOC102138275 | Histone H4. (103 aa) |
| | SOX8 | HMG box domain-containing protein. (141 aa) |
| | ENSMFAP00000002027 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | RSPO4 | R-spondin 4. (234 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A regulatory subunit A. (589 aa) |
| | ENSMFAP00000003583 | Uncharacterized protein. (379 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa) |
| | LOC102137233 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSMFAP00000004537 | Prot_ATP_ID_OB domain-containing protein. (166 aa) |
| | ASH2L | ASH2 like, histone lysine methyltransferase complex subunit. (616 aa) |
| | PSMA4 | Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (261 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | PSMD14 | 26S proteasome regulatory subunit N11. (310 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | ENSMFAP00000005693 | CSN8_PSD8_EIF3K domain-containing protein. (226 aa) |
| | H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | ENSMFAP00000005841 | Ubiquitin-like domain-containing protein. (122 aa) |
| | PSMB7 | Proteasome subunit beta. (302 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | ENSMFAP00000006175 | AAA domain-containing protein. (372 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | MEN1 | Menin 1. (615 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (748 aa) |
| | ENSMFAP00000006991 | Histone H2B; Belongs to the histone H2B family. (149 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (736 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | ENSMFAP00000007578 | BTB domain-containing protein. (553 aa) |
| | ENSMFAP00000007609 | Uncharacterized protein. (85 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa) |
| | ENSMFAP00000008086 | Uncharacterized protein. (466 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | ENSMFAP00000008526 | Histone H2A; Belongs to the histone H2A family. (106 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1315 aa) |
| | SOX12 | SRY-box transcription factor 12. (238 aa) |
| | ENSMFAP00000009536 | Proteasome subunit alpha type. (236 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (472 aa) |
| | HIST1H3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC102147067 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000009883 | Ubiquitin-like domain-containing protein. (147 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000009974 | Histone H4. (103 aa) |
| | ENSMFAP00000010006 | annotation not available (136 aa) |
| | CXXC4 | CXXC finger protein 4. (195 aa) |
| | ENSMFAP00000010019 | ANK_REP_REGION domain-containing protein. (159 aa) |
| | ENSMFAP00000010034 | annotation not available (136 aa) |
| | ENSMFAP00000010040 | Histone domain-containing protein; Belongs to the histone H2B family. (67 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | BTRC | Uncharacterized protein. (605 aa) |
| | UBC | Ubiquitin C. (645 aa) |
| | ENSMFAP00000010517 | Histone H4. (103 aa) |
| | LOC101864869 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC102136612 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSMFAP00000010627 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2BC11 | Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | ENSMFAP00000010686 | Histone H4. (103 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | ENSMFAP00000010848 | Histone H4. (103 aa) |
| | ENSMFAP00000010867 | Histone H4. (103 aa) |
| | ENSMFAP00000010884 | Histone H4. (103 aa) |
| | PSMA8 | Proteasome endopeptidase complex. (132 aa) |
| | ENSMFAP00000011138 | Histone H4. (103 aa) |
| | G7P2P1_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSMFAP00000011394 | annotation not available (126 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | ENSMFAP00000011563 | annotation not available (136 aa) |
| | H2AJ | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (129 aa) |
| | ENSMFAP00000011762 | ANK_REP_REGION domain-containing protein. (116 aa) |
| | H3C1 | H3 clustered histone 1. (136 aa) |
| | SOX1 | SRY-box transcription factor 1. (235 aa) |
| | LOC102130997 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMFAP00000011880 | Ubiquitin-like domain-containing protein. (128 aa) |
| | SOX11 | Transcription factor SOX. (441 aa) |
| | ENSMFAP00000011989 | Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa) |
| | ENSMFAP00000012015 | Protein kinase domain-containing protein. (235 aa) |
| | ENSMFAP00000012034 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMFAP00000012162 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000012290 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSMFAP00000012416 | annotation not available (136 aa) |
| | ENSMFAP00000012784 | annotation not available (136 aa) |
| | ENSMFAP00000012842 | Proteasome endopeptidase complex. (217 aa) |
| | SOX6 | SRY-box transcription factor 6. (828 aa) |
| | SOX2 | SRY-box transcription factor 2. (319 aa) |
| | FRAT1 | FRAT regulator of WNT signaling pathway 1. (279 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (233 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G8F2Z2_MACFA | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMFAP00000013484 | Histone H4. (103 aa) |
| | SOX14 | Transcription factor SOX-14; Acts as a negative regulator of transcription. (240 aa) |
| | LOC102146894 | Histone domain-containing protein. (136 aa) |
| | LOC102117118 | Ubiquitin-like domain-containing protein. (127 aa) |
| | SOX30 | Transcription factor SOX-30; Acts as both a transcriptional activator and repressor (By similarity). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (By similarity). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (By similarity). Also inhibits Wnt signaling by binding to the CTNNB1 [...] (753 aa) |
| | SOX15 | SRY-box transcription factor 15. (233 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | G8F5U3_MACFA | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | CSNK2B | Uncharacterized protein. (298 aa) |
| | ENSMFAP00000014622 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BTBD18 | BTB domain containing 18. (713 aa) |
| | ENSMFAP00000014776 | annotation not available (136 aa) |
| | ENSMFAP00000014826 | annotation not available (136 aa) |
| | ENSMFAP00000015048 | annotation not available (136 aa) |
| | ENSMFAP00000015065 | Histone H4. (103 aa) |
| | ENSMFAP00000015112 | annotation not available (126 aa) |
| | DACT3 | Uncharacterized protein. (181 aa) |
| | ENSMFAP00000015119 | Histone H4. (103 aa) |
| | ENSMFAP00000015138 | Histone H4. (103 aa) |
| | ENSMFAP00000015196 | Histone H4. (103 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | TLE7 | TLE family member 7. (441 aa) |
| | RSPO3 | R-spondin 3. (293 aa) |
| | ENSMFAP00000015936 | Ubiquitin-like domain-containing protein. (144 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | KLHL12 | BTB domain-containing protein. (568 aa) |
| | SOX3 | SRY-box transcription factor 3. (446 aa) |
| | SOX4 | Transcription factor SOX. (474 aa) |
| | ENSMFAP00000016524 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa) |
| | ENSMFAP00000016647 | Uncharacterized protein. (107 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa) |
| | RSPO2 | R-spondin 2. (243 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | CSNK1G3 | Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa) |
| | LEO1 | LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (334 aa) |
| | PSMD13 | PCI domain-containing protein. (399 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (805 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | PSMD12 | PCI domain-containing protein. (456 aa) |
| | SOX13 | SRY-box transcription factor 13. (621 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa) |
| | PYGO1 | Pygopus family PHD finger 1. (419 aa) |
| | CSNK1G2 | Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1118 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (673 aa) |
| | ENSMFAP00000021715 | Proteasome subunit alpha type. (174 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like. (243 aa) |
| | LGR6 | Leucine rich repeat containing G protein-coupled receptor 6. (966 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSMFAP00000022290 | Histone domain-containing protein. (113 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (589 aa) |
| | PSME1 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (249 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (542 aa) |
| | ENSMFAP00000023218 | AAA domain-containing protein; Belongs to the AAA ATPase family. (366 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa) |
| | PSMA6 | Proteasome subunit alpha type. (252 aa) |
| | SOX17 | Uncharacterized protein. (416 aa) |
| | USP34 | Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3475 aa) |
| | BCL9 | BCL9 transcription coactivator. (1426 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (837 aa) |
| | RSPO1 | R-spondin 1. (262 aa) |
| | PSMC5 | 26S proteasome regulatory subunit T6; Belongs to the AAA ATPase family. (406 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | SOX7 | SRY-box transcription factor 7. (388 aa) |
| | SOX21 | SRY-box transcription factor 21. (222 aa) |
| | RNF43 | RING-type domain-containing protein. (783 aa) |
| | RYK | Receptor like tyrosine kinase. (585 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa) |
| | TCF7 | Transcription factor 7. (398 aa) |
| | PSMB6 | Proteasome subunit beta. (250 aa) |
| | PYGO2 | Pygopus family PHD finger 2. (408 aa) |
| | HMGXB4 | HMG-box containing 4. (644 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | H3F3A | annotation not available (136 aa) |
| | ENSMFAP00000027900 | ANK_REP_REGION domain-containing protein. (163 aa) |
| | SOST | Sclerostin. (213 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | CBY1 | Uncharacterized protein. (169 aa) |
| | HMGXB3 | HMG-box containing 3. (1512 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | AMER1 | APC membrane recruitment protein 1. (990 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | LOC102133669 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (269 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | SOX18 | SRY-box transcription factor 18. (325 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (315 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | LOC102144252 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (445 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2301 aa) |
| | SLC39A13 | Solute carrier family 39 member 13. (364 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | TLE6 | TLE family member 6, subcortical maternal complex member. (572 aa) |
| | ENSMFAP00000034298 | Histone H3; Belongs to the histone H3 family. (141 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). (508 aa) |
| | PSME4 | Proteasome activator subunit 4. (1844 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1608 aa) |
| | ENSMFAP00000034774 | Uncharacterized protein. (158 aa) |
| | LRTM1 | Leucine rich repeats and transmembrane domains 1. (345 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (782 aa) |
| | PSMC3 | AAA domain-containing protein; Belongs to the AAA ATPase family. (451 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | ENSMFAP00000035194 | AAA domain-containing protein; Belongs to the AAA ATPase family. (418 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | ENSMFAP00000035756 | Uncharacterized protein. (197 aa) |
| | LGR4 | Leucine rich repeat containing G protein-coupled receptor 4. (924 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (524 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | PSMC4 | 26S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] (418 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (907 aa) |
| | RPS27A | Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa) |
| | BHMG1 | Basic helix-loop-helix and HMG-box containing 1. (636 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (266 aa) |
| | WIF1 | WNT inhibitory factor 1. (445 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | KMT2D | Lysine methyltransferase 2D. (5538 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (322 aa) |
| | RBBP5 | RB binding protein 5, histone lysine methyltransferase complex subunit. (548 aa) |
| | BCL9L | BCL9 like. (1500 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | ENSMFAP00000039848 | MPN domain-containing protein. (149 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (667 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (2028 aa) |
| | ENSMFAP00000040580 | Uncharacterized protein. (507 aa) |
| | UBB | Uncharacterized protein. (219 aa) |
| | ZNRF3 | Zinc and ring finger 3. (843 aa) |
| | APC | APC regulator of WNT signaling pathway. (2861 aa) |
| | RNF146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (360 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (153 aa) |
| | ENSMFAP00000041691 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | ENSMFAP00000042309 | Uncharacterized protein. (191 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (165 aa) |
| | RBX1 | RING-box protein 1. (108 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (497 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa) |
| | ENSMFAP00000043336 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | FZD8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3859 aa) |
| | ENSMFAP00000045746 | Zf-rbx1 domain-containing protein. (93 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (403 aa) |
