58 items (Macaca fascicularis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	ENSMFAP00000045746	Zf-rbx1 domain-containing protein. (93 aa)
	ENSMFAP00000045669	SKIP_SNW domain-containing protein. (467 aa)
	MAMLD1	Mastermind like domain containing 1. (1006 aa)
	EP300	E1A binding protein p300. (2414 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	ENSMFAP00000043974	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (167 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
	RBX1	RING-box protein 1. (108 aa)
	UBB	Uncharacterized protein. (219 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	RPS27A	Brain cDNA, clone: QccE-15346, similar to human ribosomal protein S27a (RPS27A). (156 aa)
	NCOR1	Nuclear receptor corepressor 1. (2442 aa)
	CREBBP	CREB binding protein. (2442 aa)
	LRBA	LPS responsive beige-like anchor protein. (2852 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (782 aa)
	HDAC8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (377 aa)
	CDK8	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
	ENSMFAP00000031351	Uncharacterized protein; Belongs to the SKP1 family. (166 aa)
	ENSMFAP00000030335	Uncharacterized protein; Belongs to the SKP1 family. (141 aa)
	TLE1	TLE family member 1, transcriptional corepressor. (770 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	KXD1	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (232 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (788 aa)
	ENSMFAP00000025317	Hist_deacetyl domain-containing protein. (258 aa)
	HDAC6	Histone deacetylase 6. (1215 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1122 aa)
	KAT2B	Lysine acetyltransferase 2B. (731 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	HIF1A	Uncharacterized protein. (831 aa)
	TLE4	TLE family member 4, transcriptional corepressor. (805 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1151 aa)
	CCNC	Cyclin C; Belongs to the cyclin family. (283 aa)
	ENSMFAP00000012453	Hist_deacetyl domain-containing protein. (223 aa)
	ENSMFAP00000012290	Ubiquitin-like domain-containing protein. (156 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
	LOC101864869	Ubiquitin-like domain-containing protein. (156 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (543 aa)
	NBEA	Neurobeachin. (2946 aa)
	TBL1X	F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa)
	ENSMFAP00000010148	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa)
	ENSMFAP00000009883	Ubiquitin-like domain-containing protein. (147 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	TLE2	TLE family member 2, transcriptional corepressor. (736 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	NCOR2	Nuclear receptor corepressor 2. (2510 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (529 aa)
	HES4	Hes family bHLH transcription factor 4. (225 aa)
	HDAC11	Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (319 aa)
	HDAC10	Histone deacetylase 10. (672 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	SNW1	SNW domain containing 1. (571 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNC	CDK8	ENSMFAP00000015414	ENSMFAP00000032978	Cyclin C; Belongs to the cyclin family.	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	0.994
CDK8	CCNC	ENSMFAP00000032978	ENSMFAP00000015414	Cyclin dependent kinase 8; Belongs to the protein kinase superfamily.	Cyclin C; Belongs to the cyclin family.	0.994
CREBBP	ENSMFAP00000010148	ENSMFAP00000036160	ENSMFAP00000010148	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.624
CREBBP	ENSMFAP00000012453	ENSMFAP00000036160	ENSMFAP00000012453	CREB binding protein.	Hist_deacetyl domain-containing protein.	0.664
CREBBP	ENSMFAP00000025317	ENSMFAP00000036160	ENSMFAP00000025317	CREB binding protein.	Hist_deacetyl domain-containing protein.	0.624
CREBBP	ENSMFAP00000043974	ENSMFAP00000036160	ENSMFAP00000043974	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.624
CREBBP	ENSMFAP00000045669	ENSMFAP00000036160	ENSMFAP00000045669	CREB binding protein.	SKIP_SNW domain-containing protein.	0.651
CREBBP	EP300	ENSMFAP00000036160	ENSMFAP00000044906	CREB binding protein.	E1A binding protein p300.	0.998
CREBBP	HDAC1	ENSMFAP00000036160	ENSMFAP00000008745	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.624
CREBBP	HDAC10	ENSMFAP00000036160	ENSMFAP00000002742	CREB binding protein.	Histone deacetylase 10.	0.484
CREBBP	HDAC11	ENSMFAP00000036160	ENSMFAP00000003038	CREB binding protein.	Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).	0.495
CREBBP	HDAC2	ENSMFAP00000036160	ENSMFAP00000000083	CREB binding protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.716
CREBBP	HDAC3	ENSMFAP00000036160	ENSMFAP00000005789	CREB binding protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.664
CREBBP	HDAC4	ENSMFAP00000036160	ENSMFAP00000020858	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.535
CREBBP	HDAC5	ENSMFAP00000036160	ENSMFAP00000023829	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.554
CREBBP	HDAC6	ENSMFAP00000036160	ENSMFAP00000025185	CREB binding protein.	Histone deacetylase 6.	0.640
CREBBP	HDAC7	ENSMFAP00000036160	ENSMFAP00000025456	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.586
CREBBP	HDAC8	ENSMFAP00000036160	ENSMFAP00000033409	CREB binding protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.543
CREBBP	HDAC9	ENSMFAP00000036160	ENSMFAP00000011481	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.548
CREBBP	HIF1A	ENSMFAP00000036160	ENSMFAP00000018622	CREB binding protein.	Uncharacterized protein.	0.998

page 1 of 53

Server load: medium (46%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About