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GLUD2 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (534 aa) | ||||
IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa) | ||||
GABPB2 | ANK_REP_REGION domain-containing protein. (112 aa) | ||||
HELZ2 | Helicase with zinc finger 2. (2649 aa) | ||||
ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) | ||||
HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa) | ||||
ENSMFAP00000006305 | Uncharacterized protein. (62 aa) | ||||
SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (348 aa) | ||||
TFAM | Transcription factor A, mitochondrial. (248 aa) | ||||
TFB2M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (396 aa) | ||||
TBL1X | F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa) | ||||
TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (543 aa) | ||||
NCOA6 | Nuclear receptor coactivator 6. (2065 aa) | ||||
ENSMFAP00000011991 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) | ||||
NCOA2 | Nuclear receptor coactivator. (1464 aa) | ||||
ENSMFAP00000012453 | Hist_deacetyl domain-containing protein. (223 aa) | ||||
LOC102120841 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
ENSMFAP00000013592 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
MTERF2 | Mitochondrial transcription termination factor 2. (385 aa) | ||||
CYCS | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) | ||||
TGS1 | Trimethylguanosine synthase 1. (854 aa) | ||||
LOC102117102 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) | ||||
ENSMFAP00000014371 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) | ||||
ENSMFAP00000014426 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa) | ||||
MEF2D | Myocyte enhancer factor 2D. (521 aa) | ||||
SRFBP1 | Serum response factor binding protein 1. (429 aa) | ||||
POLRMT | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1228 aa) | ||||
PPARA | Peroxisome proliferator activated receptor alpha. (467 aa) | ||||
TFB1M | Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). (345 aa) | ||||
SMARCD3 | SWIB domain-containing protein. (483 aa) | ||||
TWNK | Twinkle mtDNA helicase. (582 aa) | ||||
SSBP1 | Single stranded DNA binding protein 1. (148 aa) | ||||
ENSMFAP00000021707 | Nuclear receptor domain-containing protein. (255 aa) | ||||
HCFC1 | Host cell factor C1. (2080 aa) | ||||
ESRRA | Estrogen related receptor alpha. (422 aa) | ||||
NRF1 | Nuclear respiratory factor 1. (522 aa) | ||||
GABPB1 | ANK_REP_REGION domain-containing protein. (319 aa) | ||||
ENSMFAP00000022686 | Uncharacterized protein. (440 aa) | ||||
CRTC3 | CREB regulated transcription coactivator 3. (619 aa) | ||||
LOC101926166 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (562 aa) | ||||
RXRA | Retinoid X receptor alpha. (443 aa) | ||||
MEF2C | Myocyte enhancer factor 2C. (483 aa) | ||||
CRTC1 | CREB regulated transcription coactivator 1. (628 aa) | ||||
SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa) | ||||
PPARGC1B | PPARG coactivator 1 beta. (1023 aa) | ||||
ENSMFAP00000031523 | Uncharacterized protein. (91 aa) | ||||
CAMK4 | Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa) | ||||
CARM1 | Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (593 aa) | ||||
POLG2 | DNA polymerase gamma 2, accessory subunit. (431 aa) | ||||
ENSMFAP00000034444 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (97 aa) | ||||
ENSMFAP00000035291 | Uncharacterized protein. (159 aa) | ||||
ATP5F1B | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa) | ||||
CREBBP | CREB binding protein. (2442 aa) | ||||
ALAS1 | 5-aminolevulinate synthase. (640 aa) | ||||
NCOR1 | Nuclear receptor corepressor 1. (2442 aa) | ||||
ACSS2 | Acyl-CoA synthetase short chain family member 2. (714 aa) | ||||
NR1D1 | Nuclear receptor subfamily 1 group D member 1. (613 aa) | ||||
MTERF1 | Mitochondrial transcription termination factor 1. (399 aa) | ||||
MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa) | ||||
CRTC2 | CREB regulated transcription coactivator 2. (694 aa) | ||||
SOD2 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa) | ||||
NCOA1 | Nuclear receptor coactivator 1. (1534 aa) | ||||
CHD9 | Chromodomain helicase DNA binding protein 9. (2901 aa) | ||||
GABPA | GA binding protein transcription factor subunit alpha. (454 aa) | ||||
CREB1 | cAMP responsive element binding protein 1. (341 aa) | ||||
SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa) | ||||
PPARGC1A | PPARG coactivator 1 alpha. (798 aa) |