STRINGSTRING
GLUD2 GLUD2 IDH2 IDH2 GABPB2 GABPB2 HELZ2 HELZ2 ATF2 ATF2 HDAC3 HDAC3 ENSMFAP00000006305 ENSMFAP00000006305 SIRT5 SIRT5 TFAM TFAM TFB2M TFB2M TBL1X TBL1X TBL1XR1 TBL1XR1 NCOA6 NCOA6 ENSMFAP00000011991 ENSMFAP00000011991 NCOA2 NCOA2 ENSMFAP00000012453 ENSMFAP00000012453 LOC102120841 LOC102120841 ENSMFAP00000013592 ENSMFAP00000013592 MTERF2 MTERF2 CYCS CYCS TGS1 TGS1 LOC102117102 LOC102117102 ENSMFAP00000014371 ENSMFAP00000014371 ENSMFAP00000014426 ENSMFAP00000014426 MEF2D MEF2D SRFBP1 SRFBP1 POLRMT POLRMT PPARA PPARA TFB1M TFB1M SMARCD3 SMARCD3 TWNK TWNK SSBP1 SSBP1 ENSMFAP00000021707 ENSMFAP00000021707 HCFC1 HCFC1 ESRRA ESRRA NRF1 NRF1 GABPB1 GABPB1 ENSMFAP00000022686 ENSMFAP00000022686 CRTC3 CRTC3 LOC101926166 LOC101926166 RXRA RXRA MEF2C MEF2C CRTC1 CRTC1 SIRT3 SIRT3 PPARGC1B PPARGC1B ENSMFAP00000031523 ENSMFAP00000031523 CAMK4 CAMK4 CARM1 CARM1 POLG2 POLG2 ENSMFAP00000034444 ENSMFAP00000034444 ENSMFAP00000035291 ENSMFAP00000035291 ATP5F1B ATP5F1B CREBBP CREBBP ALAS1 ALAS1 NCOR1 NCOR1 ACSS2 ACSS2 NR1D1 NR1D1 MTERF1 MTERF1 MED1 MED1 CRTC2 CRTC2 SOD2 SOD2 NCOA1 NCOA1 CHD9 CHD9 GABPA GABPA CREB1 CREB1 SIRT4 SIRT4 PPARGC1A PPARGC1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (534 aa)
IDH2Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GABPB2ANK_REP_REGION domain-containing protein. (112 aa)
HELZ2Helicase with zinc finger 2. (2649 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
ENSMFAP00000006305Uncharacterized protein. (62 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (348 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
TFB2MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (396 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (569 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (543 aa)
NCOA6Nuclear receptor coactivator 6. (2065 aa)
ENSMFAP00000011991Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ENSMFAP00000012453Hist_deacetyl domain-containing protein. (223 aa)
LOC102120841Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMFAP00000013592Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MTERF2Mitochondrial transcription termination factor 2. (385 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TGS1Trimethylguanosine synthase 1. (854 aa)
LOC102117102Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ENSMFAP00000014371Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
ENSMFAP00000014426Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
SRFBP1Serum response factor binding protein 1. (429 aa)
POLRMTDNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1228 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
TFB1MDimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). (345 aa)
SMARCD3SWIB domain-containing protein. (483 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
ENSMFAP00000021707Nuclear receptor domain-containing protein. (255 aa)
HCFC1Host cell factor C1. (2080 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
GABPB1ANK_REP_REGION domain-containing protein. (319 aa)
ENSMFAP00000022686Uncharacterized protein. (440 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
LOC101926166ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (562 aa)
RXRARetinoid X receptor alpha. (443 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CRTC1CREB regulated transcription coactivator 1. (628 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
ENSMFAP00000031523Uncharacterized protein. (91 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (593 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (431 aa)
ENSMFAP00000034444Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (97 aa)
ENSMFAP00000035291Uncharacterized protein. (159 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
CREBBPCREB binding protein. (2442 aa)
ALAS15-aminolevulinate synthase. (640 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
MTERF1Mitochondrial transcription termination factor 1. (399 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
NCOA1Nuclear receptor coactivator 1. (1534 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2901 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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