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| | ENSMFAP00000043974 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (462 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa) |
| | NUP37 | Nucleoporin 37. (326 aa) |
| | TFE3 | Transcription factor binding to IGHM enhancer 3. (575 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (798 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (461 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1047 aa) |
| | ENSMFAP00000045276 | RRM domain-containing protein. (281 aa) |
| | ENSMFAP00000045186 | BTB domain-containing protein. (145 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (853 aa) |
| | EP300 | E1A binding protein p300. (2414 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | TDG | Thymine DNA glycosylase. (410 aa) |
| | ENSMFAP00000000260 | Uncharacterized protein. (454 aa) |
| | NUP62CL | Nsp1_C domain-containing protein. (238 aa) |
| | NUP153 | Nucleoporin 153. (1492 aa) |
| | ENSMFAP00000000767 | Uncharacterized protein. (208 aa) |
| | NR3C1 | Nuclear receptor subfamily 3 group C member 1. (778 aa) |
| | E4F1 | E4F transcription factor 1. (784 aa) |
| | SCML1 | Scm polycomb group protein like 1. (329 aa) |
| | ENSMFAP00000001669 | Uncharacterized protein. (268 aa) |
| | CFAP53 | Cilia and flagella associated protein 53. (514 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (464 aa) |
| | LOC102121517 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa) |
| | LOC102138275 | Histone H4. (103 aa) |
| | NUP214 | Nucleoporin 214. (2090 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) |
| | CDCA8 | Cell division cycle associated 8. (280 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (403 aa) |
| | ENSMFAP00000004513 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa) |
| | LOC102128732 | Rad60-SLD domain-containing protein. (94 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (453 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (634 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2510 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa) |
| | PML | Promyelocytic leukemia. (882 aa) |
| | ENSMFAP00000005736 | Protein kinase domain-containing protein. (334 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | RING1 | Ring finger protein 1. (412 aa) |
| | ENSMFAP00000006058 | Uncharacterized protein. (305 aa) |
| | HNRNPC | RRM domain-containing protein. (321 aa) |
| | ENSMFAP00000006551 | Uncharacterized protein. (229 aa) |
| | NR3C2 | Nuclear receptor subfamily 3 group C member 2. (988 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | ENSMFAP00000007027 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa) |
| | NR1I2 | Nuclear receptor subfamily 1 group I member 2. (473 aa) |
| | BIRC5 | Uncharacterized protein. (209 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa) |
| | FOXL2 | Forkhead box L2. (376 aa) |
| | RNF2 | Ring finger protein 2. (336 aa) |
| | CBX8 | Chromobox 8. (420 aa) |
| | PCGF2 | Polycomb group ring finger 2. (344 aa) |
| | PHC3 | Polyhomeotic homolog 3. (995 aa) |
| | POM121C | Uncharacterized protein. (1225 aa) |
| | NR5A2 | Nuclear receptor subfamily 5 group A member 2. (541 aa) |
| | KCTD2 | Potassium channel tetramerization domain containing 2. (263 aa) |
| | VTCN1 | V-set domain containing T cell activation inhibitor 1. (285 aa) |
| | SP3 | Sp3 transcription factor. (756 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | ZNF618 | Zinc finger protein 618. (1012 aa) |
| | NPM1 | Uncharacterized protein. (305 aa) |
| | NUP35 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (326 aa) |
| | SP5 | Sp5 transcription factor. (398 aa) |
| | NR2C1 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] (603 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa) |
| | ENSMFAP00000009974 | Histone H4. (103 aa) |
| | HIC2 | HIC ZBTB transcriptional repressor 2. (615 aa) |
| | SEH1L | SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa) |
| | ENSMFAP00000010148 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (421 aa) |
| | NDC1 | NDC1 transmembrane nucleoporin. (523 aa) |
| | ENSMFAP00000010517 | Histone H4. (103 aa) |
| | LOC102138794 | RING-type domain-containing protein. (321 aa) |
| | ENSMFAP00000010659 | WD_REPEATS_REGION domain-containing protein. (377 aa) |
| | ENSMFAP00000010686 | Histone H4. (103 aa) |
| | SUMO3-2 | Ubiquitin-like domain-containing protein. (141 aa) |
| | THRB | Uncharacterized protein. (476 aa) |
| | ENSMFAP00000010848 | Histone H4. (103 aa) |
| | ENSMFAP00000010867 | Histone H4. (103 aa) |
| | ENSMFAP00000010884 | Histone H4. (103 aa) |
| | PHC1 | Polyhomeotic homolog 1. (1003 aa) |
| | ENSMFAP00000011138 | Histone H4. (103 aa) |
| | XRCC4 | XRCC4. (334 aa) |
| | RANBP3L | RAN binding protein 3 like. (490 aa) |
| | ENSMFAP00000011486 | Uncharacterized protein. (702 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (317 aa) |
| | ZBTB38 | Zinc finger and BTB domain containing 38. (1195 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | MAGEE2 | MAGE family member E2. (523 aa) |
| | ENSMFAP00000012391 | Ubiquitin-like domain-containing protein. (132 aa) |
| | ZBED1 | Zinc finger BED-type containing 1. (694 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2000 aa) |
| | NRIP1 | Nuclear receptor interacting protein 1. (1155 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1632 aa) |
| | SUMO2 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] (95 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | NFATC2IP | NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). (468 aa) |
| | ENSMFAP00000013484 | Histone H4. (103 aa) |
| | MAGEF1 | MAGE family member F1. (308 aa) |
| | ZBED4 | Zinc finger BED-type containing 4. (1171 aa) |
| | MBD1 | Methyl-CpG binding domain protein 1. (630 aa) |
| | BIRC5-2 | Uncharacterized protein. (142 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa) |
| | RANBP2 | RAN binding protein 2. (3221 aa) |
| | G7PB98_MACFA | Small ubiquitin-related modifier. (95 aa) |
| | CBX4 | Chromobox 4. (558 aa) |
| | ENSMFAP00000015065 | Histone H4. (103 aa) |
| | ENSMFAP00000015119 | Histone H4. (103 aa) |
| | ENSMFAP00000015138 | Histone H4. (103 aa) |
| | ENSMFAP00000015196 | Histone H4. (103 aa) |
| | SUMO1 | Ubiquitin-like domain-containing protein. (146 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | SP100 | SP100 nuclear antigen. (863 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (899 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | ENSMFAP00000016028 | Uncharacterized protein. (232 aa) |
| | NUP54 | Testis cDNA, clone: QtsA-18807, similar to human nucleoporin 54kDa (NUP54). (508 aa) |
| | ENSMFAP00000016083 | RRM domain-containing protein. (250 aa) |
| | MTA1 | Metastasis associated 1. (726 aa) |
| | RNF169 | Ring finger protein 169. (709 aa) |
| | INCENP | Inner centromere protein. (897 aa) |
| | RANBP3 | Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). (567 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (467 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1092 aa) |
| | UHRF2 | Ubiquitin like with PHD and ring finger domains 2. (802 aa) |
| | ENSMFAP00000020443 | Rad21_Rec8 domain-containing protein. (521 aa) |
| | ENSMFAP00000019793 | DJ-1_PfpI domain-containing protein. (134 aa) |
| | FAM111B | Family with sequence similarity 111 member B. (732 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2439 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | NUP107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa) |
| | SUMO3 | Ubiquitin-like domain-containing protein. (137 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | RARA | Retinoic acid receptor alpha. (462 aa) |
| | THRA | Uncharacterized protein. (602 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (620 aa) |
| | NUP160 | Nucleoporin 160. (1436 aa) |
| | FOXD2 | Forkhead box D2. (495 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (939 aa) |
| | CBX2 | Chromobox 2. (555 aa) |
| | ENSMFAP00000020733 | Uncharacterized protein. (103 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1085 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (601 aa) |
| | PHC2 | Polyhomeotic homolog 2. (859 aa) |
| | ENSMFAP00000021572 | Uncharacterized protein. (107 aa) |
| | NUP50 | Testis cDNA clone: QtsA-12809, similar to human nucleoporin 50kDa (NUP50), transcript variant 2. (468 aa) |
| | SATB2 | DNA-binding protein SATB. (733 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | BLM | BLM RecQ like helicase. (1416 aa) |
| | NUP43 | WD_REPEATS_REGION domain-containing protein. (380 aa) |
| | RORA | RAR related orphan receptor A. (555 aa) |
| | RAE1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. (368 aa) |
| | WRN | WRN RecQ like helicase. (1428 aa) |
| | ENSMFAP00000023932 | Uncharacterized protein. (256 aa) |
| | NCOA5 | Nuclear receptor coactivator 5. (584 aa) |
| | ING1 | Inhibitor of growth protein. (417 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1626 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1073 aa) |
| | ENSMFAP00000025317 | Hist_deacetyl domain-containing protein. (258 aa) |
| | ENSMFAP00000025396 | Uncharacterized protein. (274 aa) |
| | HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa) |
| | NR5A1 | Nuclear receptor subfamily 5 group A member 1. (461 aa) |
| | ENSMFAP00000025493 | Uncharacterized protein. (274 aa) |
| | BRCA1 | Uncharacterized protein. (1884 aa) |
| | NUP133 | Nucleoporin 133. (1156 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | NUP210 | Nucleoporin 210. (1887 aa) |
| | ENSMFAP00000026148 | Small ubiquitin-related modifier. (95 aa) |
| | RXRA | Retinoid X receptor alpha. (443 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (733 aa) |
| | CETN2 | Uncharacterized protein. (172 aa) |
| | ENSMFAP00000027483 | annotation not available (107 aa) |
| | NUP98 | Nucleoporin 98. (1610 aa) |
| | ENSMFAP00000027910 | Rad60-SLD domain-containing protein. (81 aa) |
| | ENSMFAP00000028396 | DJ-1_PfpI domain-containing protein. (166 aa) |
| | SUMO1-2 | Rad60-SLD domain-containing protein. (67 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (266 aa) |
| | ENSMFAP00000029118 | Small ubiquitin-related modifier. (104 aa) |
| | NUP85 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa) |
| | PARK7 | DJ-1_PfpI domain-containing protein. (189 aa) |
| | SATB1 | DNA-binding protein SATB. (795 aa) |
| | ENSMFAP00000029982 | Uncharacterized protein. (102 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | PGR | Progesterone receptor. (936 aa) |
| | SCML2 | Scm polycomb group protein like 2. (701 aa) |
| | NUP93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (880 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | NUP58 | Nucleoporin 58. (599 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (895 aa) |
| | RANGAP1 | Ran GTPase activating protein 1. (639 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (611 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | NUP210L | Nucleoporin 210 like. (1861 aa) |
| | CASP8AP2 | Caspase 8 associated protein 2. (1986 aa) |
| | PCNA | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] (261 aa) |
| | NUP188 | Nucleoporin 188. (1749 aa) |
| | MAGEB6B | MAGE family member B6B. (407 aa) |
| | CETN3 | Centrin 3. (191 aa) |
| | SCMH1 | SAM domain-containing protein. (660 aa) |
| | ENSMFAP00000031774 | DJ-1_PfpI domain-containing protein. (133 aa) |
| | NOP58 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Belongs to the NOP5/NOP56 family. (540 aa) |
| | NUP88 | Nucleoporin 88. (741 aa) |
| | SEC13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa) |
| | MAGEB6 | MAGE family member B6. (407 aa) |
| | ENSMFAP00000032552 | ROKNT domain-containing protein. (71 aa) |
| | NUP42 | Nucleoporin 42. (435 aa) |
| | NUP62 | Nucleoporin 62. (338 aa) |
| | ENSMFAP00000032863 | Uncharacterized protein. (238 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | ENSMFAP00000033991 | Uncharacterized protein. (418 aa) |
| | FOXD4L1 | Forkhead box D4 like 1. (408 aa) |
| | ENSMFAP00000034417 | Uncharacterized protein. (422 aa) |
| | ENSMFAP00000034482 | Rad60-SLD domain-containing protein. (86 aa) |
| | CBX5 | Chromobox 5. (191 aa) |
| | ENSMFAP00000034738 | KH domain-containing protein. (380 aa) |
| | TFAP2C | Transcription factor AP-2 gamma. (521 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | SAFB | Scaffold attachment factor B. (917 aa) |
| | SHLD1 | Shieldin complex subunit 1. (269 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2. (598 aa) |
| | ZMIZ2 | Zinc finger MIZ-type containing 2. (921 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (2091 aa) |
| | CREBBP | CREB binding protein. (2442 aa) |
| | SP110 | SP110 nuclear body protein. (550 aa) |
| | STAG1 | Stromal antigen 1. (1258 aa) |
| | ENSMFAP00000036744 | Uncharacterized protein. (90 aa) |
| | SP4 | Sp4 transcription factor. (784 aa) |
| | L3MBTL2 | L3MBTL histone methyl-lysine binding protein 2. (705 aa) |
| | ENSMFAP00000037126 | Rad60-SLD domain-containing protein. (71 aa) |
| | NUP205 | Nucleoporin 205. (2013 aa) |
| | BMI1 | RING-type domain-containing protein. (326 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa) |
| | ENSMFAP00000037907 | Fork-head domain-containing protein. (260 aa) |
| | VDR | Vitamin D receptor. (477 aa) |
| | MITF | Melanocyte inducing transcription factor. (519 aa) |
| | MAGEE1 | Melanoma-associated antigen E1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). (891 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (393 aa) |
| | DAXX | Death domain associated protein. (740 aa) |
| | PIAS1 | Uncharacterized protein. (653 aa) |
| | ENSMFAP00000039110 | TTD domain-containing protein. (163 aa) |
| | DDX17 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. (733 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (510 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa) |
| | TRIM28 | Tripartite motif containing 28. (721 aa) |
| | ENSMFAP00000040050 | Uncharacterized protein. (287 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (469 aa) |
| | ZNF131 | Zinc finger protein 131. (629 aa) |
| | MRTFA | Myocardin related transcription factor A. (970 aa) |
| | NCOA1 | Nuclear receptor coactivator 1. (1534 aa) |
| | SP140 | SP140 nuclear body protein. (866 aa) |
| | SAFB2 | Scaffold attachment factor B2. (953 aa) |
| | TFAP2A | Transcription factor AP-2 alpha. (439 aa) |
| | AAAS | Aladin WD repeat nucleoporin. (546 aa) |
| | SUZ12 | SUZ12 polycomb repressive complex 2 subunit. (739 aa) |
| | MAGEB4 | MAGE family member B4. (268 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4818 aa) |
| | TFEB | Transcription factor EB. (490 aa) |
| | TRIM7 | Tripartite motif containing 7. (511 aa) |
| | NUP155 | Nucleoporin 155. (1449 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | SMC5 | SMC_N domain-containing protein. (1044 aa) |
| | ZNF350 | Zinc finger protein 350. (533 aa) |
