STRINGSTRING
MAPK3 MAPK3 MEIOB MEIOB NUP37 NUP37 HSPA1L HSPA1L ENSMFAP00000044257 ENSMFAP00000044257 DNAJB4 DNAJB4 ENSMFAP00000043943 ENSMFAP00000043943 ENSMFAP00000043889 ENSMFAP00000043889 DNAJB3 DNAJB3 EFCAB10 EFCAB10 ST13 ST13 NUP155 NUP155 AAAS AAAS HSPA5 HSPA5 YWHAE YWHAE DNAJB2 DNAJB2 ENSMFAP00000040719 ENSMFAP00000040719 BAG5 BAG5 SIRT1 SIRT1 ENSMFAP00000039569 ENSMFAP00000039569 HSPA8 HSPA8 METRNL METRNL OGFR OGFR NUP205 NUP205 HSPA12A HSPA12A HSPA6 HSPA6 SHLD1 SHLD1 ENSMFAP00000034794 ENSMFAP00000034794 ENSMFAP00000034373 ENSMFAP00000034373 ANKRD45 ANKRD45 LOC107126466 LOC107126466 HSPA4L HSPA4L NUP62 NUP62 NUP42 NUP42 ENSMFAP00000032511 ENSMFAP00000032511 SEC13 SEC13 NUP88 NUP88 NUP188 NUP188 NUP210L NUP210L DNAJB6 DNAJB6 NUP58 NUP58 NUP93 NUP93 DNAJB1 DNAJB1 HSPA12B HSPA12B RPA3 RPA3 NUP85 NUP85 TMEM59L TMEM59L HSPA13 HSPA13 HSPA9 HSPA9 NUP98 NUP98 BAG1 BAG1 DNAJC2 DNAJC2 NUP210 NUP210 NUP133 NUP133 HSPA14 HSPA14 BAG2 BAG2 NCOA5 NCOA5 RAE1 RAE1 ENSMFAP00000022974 ENSMFAP00000022974 HSPA2 HSPA2 ENSMFAP00000022812 ENSMFAP00000022812 NUP43 NUP43 ATM ATM DNAJB13 DNAJB13 ENSMFAP00000021941 ENSMFAP00000021941 BAG3 BAG3 NUP50 NUP50 HIKESHI HIKESHI MAPKAPK2 MAPKAPK2 HSF2 HSF2 TPR TPR RPS19BP1 RPS19BP1 NUP107 NUP107 DNAJB5 DNAJB5 HSF4 HSF4 BAG4 BAG4 NUP160 NUP160 DNAJC7 DNAJC7 OGFRL1 OGFRL1 NUP54 NUP54 ENSMFAP00000015786 ENSMFAP00000015786 ENSMFAP00000015231 ENSMFAP00000015231 HSF1 HSF1 RANBP2 RANBP2 DNAJB8 DNAJB8 METRN METRN ENSMFAP00000014202 ENSMFAP00000014202 HSPA4 HSPA4 ENSMFAP00000013161 ENSMFAP00000013161 HSPH1 HSPH1 ENSMFAP00000010659 ENSMFAP00000010659 NDC1 NDC1 SEH1L SEH1L RPA1 RPA1 NUP35 NUP35 ATR ATR ENSMFAP00000008080 ENSMFAP00000008080 POM121C POM121C ENSMFAP00000007027 ENSMFAP00000007027 GSK3B GSK3B ENSMFAP00000006110 ENSMFAP00000006110 LOC102139885 LOC102139885 MAPK1 MAPK1 ENSMFAP00000003736 ENSMFAP00000003736 ENSMFAP00000003622 ENSMFAP00000003622 ENSMFAP00000003043 ENSMFAP00000003043 ENSMFAP00000002425 ENSMFAP00000002425 NUP214 NUP214 ENSMFAP00000000858 ENSMFAP00000000858 NUP153 NUP153 ENSMFAP00000000762 ENSMFAP00000000762 NUP62CL NUP62CL HSF5 HSF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase. (322 aa)
MEIOBMeiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] (471 aa)
NUP37Nucleoporin 37. (326 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (643 aa)
ENSMFAP00000044257Uncharacterized protein. (83 aa)
DNAJB4J domain-containing protein. (344 aa)
ENSMFAP00000043943Uncharacterized protein. (65 aa)
ENSMFAP00000043889Uncharacterized protein; Belongs to the heat shock protein 70 family. (619 aa)
DNAJB3J domain-containing protein. (232 aa)
EFCAB10EF-hand calcium binding domain 10. (149 aa)
ST13ST13 Hsp70 interacting protein. (369 aa)
NUP155Nucleoporin 155. (1449 aa)
AAASAladin WD repeat nucleoporin. (546 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
DNAJB2J domain-containing protein. (324 aa)
ENSMFAP0000004071914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (217 aa)
BAG5BCL2 associated athanogene 5. (488 aa)
SIRT1Sirtuin 1. (743 aa)
ENSMFAP00000039569TPR_REGION domain-containing protein. (218 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
METRNLMeteorin like, glial cell differentiation regulator. (331 aa)
OGFROpioid growth factor receptor. (691 aa)
NUP205Nucleoporin 205. (2013 aa)
HSPA12AHeat shock protein family A (Hsp70) member 12A. (693 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (600 aa)
SHLD1Shieldin complex subunit 1. (269 aa)
ENSMFAP00000034794HipN domain-containing protein. (158 aa)
ENSMFAP00000034373Uncharacterized protein. (201 aa)
ANKRD45ANK_REP_REGION domain-containing protein. (266 aa)
LOC107126466HSF_DOMAIN domain-containing protein. (355 aa)
HSPA4LHeat shock protein family A (Hsp70) member 4 like. (840 aa)
NUP62Nucleoporin 62. (338 aa)
NUP42Nucleoporin 42. (435 aa)
ENSMFAP00000032511Uncharacterized protein. (372 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
NUP88Nucleoporin 88. (741 aa)
NUP188Nucleoporin 188. (1749 aa)
NUP210LNucleoporin 210 like. (1861 aa)
DNAJB6DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). (334 aa)
NUP58Nucleoporin 58. (599 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (880 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (340 aa)
HSPA12BHeat shock protein family A (Hsp70) member 12B. (686 aa)
RPA3Uncharacterized protein. (121 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
TMEM59LTransmembrane protein 59 like. (342 aa)
HSPA13Heat shock protein family A (Hsp70) member 13. (471 aa)
HSPA9Uncharacterized protein; Belongs to the heat shock protein 70 family. (679 aa)
NUP98Nucleoporin 98. (1610 aa)
BAG1BCL2 associated athanogene 1. (345 aa)
DNAJC2DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] (621 aa)
NUP210Nucleoporin 210. (1887 aa)
NUP133Nucleoporin 133. (1156 aa)
HSPA14Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). (509 aa)
BAG2BAG domain-containing protein. (211 aa)
NCOA5Nuclear receptor coactivator 5. (584 aa)
RAE1mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. (368 aa)
ENSMFAP00000022974DnaJ_C domain-containing protein. (213 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (641 aa)
ENSMFAP00000022812Uncharacterized protein. (421 aa)
NUP43WD_REPEATS_REGION domain-containing protein. (380 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
DNAJB13DnaJ heat shock protein family (Hsp40) member B13. (316 aa)
ENSMFAP00000021941Uncharacterized protein. (362 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
NUP50Testis cDNA clone: QtsA-12809, similar to human nucleoporin 50kDa (NUP50), transcript variant 2. (468 aa)
HIKESHIHeat shock protein nuclear import factor hikeshi. (197 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (381 aa)
HSF2Heat shock transcription factor 2. (536 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
RPS19BP1Uncharacterized protein. (137 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
DNAJB5DnaJ heat shock protein family (Hsp40) member B5. (462 aa)
HSF4Heat shock transcription factor 4. (492 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
NUP160Nucleoporin 160. (1436 aa)
DNAJC7Uncharacterized protein. (545 aa)
OGFRL1Opioid growth factor receptor like 1. (452 aa)
NUP54Testis cDNA, clone: QtsA-18807, similar to human nucleoporin 54kDa (NUP54). (508 aa)
ENSMFAP00000015786Uncharacterized protein. (484 aa)
ENSMFAP00000015231Uncharacterized protein. (118 aa)
HSF1Heat shock transcription factor 1. (529 aa)
RANBP2RAN binding protein 2. (3221 aa)
DNAJB8DnaJ heat shock protein family (Hsp40) member B8. (232 aa)
METRNMeteorin, glial cell differentiation regulator. (284 aa)
ENSMFAP00000014202Uncharacterized protein; Belongs to the heat shock protein 70 family. (571 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (840 aa)
ENSMFAP00000013161HSF_DOMAIN domain-containing protein. (423 aa)
HSPH1Heat shock protein family H (Hsp110) member 1. (978 aa)
ENSMFAP00000010659WD_REPEATS_REGION domain-containing protein. (377 aa)
NDC1NDC1 transmembrane nucleoporin. (523 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (267 aa)
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (326 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ENSMFAP00000008080Uncharacterized protein. (438 aa)
POM121CUncharacterized protein. (1225 aa)
ENSMFAP00000007027Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (506 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
ENSMFAP00000006110Uncharacterized protein. (373 aa)
LOC102139885HSF_DOMAIN domain-containing protein. (475 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSMFAP00000003736BAG domain-containing protein. (360 aa)
ENSMFAP00000003622HSF_DOMAIN domain-containing protein. (287 aa)
ENSMFAP00000003043J domain-containing protein. (225 aa)
ENSMFAP00000002425STI1 domain-containing protein. (340 aa)
NUP214Nucleoporin 214. (2090 aa)
ENSMFAP00000000858STI1 domain-containing protein. (343 aa)
NUP153Nucleoporin 153. (1492 aa)
ENSMFAP00000000762Uncharacterized protein; Belongs to the heat shock protein 70 family. (578 aa)
NUP62CLNsp1_C domain-containing protein. (238 aa)
HSF5Heat shock transcription factor 5. (589 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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