STRINGSTRING
CCL2 CCL2 ATP6V0D1 ATP6V0D1 EXOSC2 EXOSC2 MYDGF MYDGF ATF4 ATF4 KHSRP KHSRP ENSMFAP00000045139 ENSMFAP00000045139 PDIA6 PDIA6 EXOSC5 EXOSC5 SSR1 SSR1 KLHDC3 KLHDC3 WIPI1 WIPI1 ENSMFAP00000043889 ENSMFAP00000043889 DNAJB11 DNAJB11 FKBP14 FKBP14 WFS1 WFS1 LOC102132274 LOC102132274 PREB PREB ERN1 ERN1 CREB3L3 CREB3L3 HSPA5 HSPA5 SRPRB SRPRB DCP2 DCP2 ENSMFAP00000041402 ENSMFAP00000041402 ASNS ASNS CEBPB CEBPB CUL7 CUL7 GSK3A GSK3A ARFGAP1 ARFGAP1 NFYA NFYA ATF6 ATF6 HDGF HDGF ZBTB17 ZBTB17 ENSMFAP00000037120 ENSMFAP00000037120 EIF2S1 EIF2S1 MYNN MYNN DNAJC3 DNAJC3 HERPUD1 HERPUD1 TSPYL2 TSPYL2 ENSMFAP00000035793 ENSMFAP00000035793 ENSMFAP00000035364 ENSMFAP00000035364 IGFBP1 IGFBP1 GFPT1 GFPT1 GOSR2 GOSR2 ENSMFAP00000033101 ENSMFAP00000033101 CAGE1 CAGE1 ENSMFAP00000032601 ENSMFAP00000032601 EIF2S2 EIF2S2 HSP90B1 HSP90B1 TATDN1 TATDN1 ZBTB46 ZBTB46 MBTPS2 MBTPS2 ZBTB47 ZBTB47 PPP2R5B PPP2R5B SERP1 SERP1 LMNA LMNA DCSTAMP DCSTAMP EXTL3 EXTL3 HERPUD2 HERPUD2 DDIT3 DDIT3 SHC1 SHC1 PARN PARN CREB3 CREB3 TATDN2 TATDN2 CTDSP2 CTDSP2 TLN1 TLN1 CREB3L2 CREB3L2 ENSMFAP00000021728 ENSMFAP00000021728 PLA2G4B PLA2G4B EXOSC6 EXOSC6 DDX11 DDX11 TPP1 TPP1 ATF3 ATF3 CTDSP1 CTDSP1 SRPRA SRPRA YIF1A YIF1A SERP2 SERP2 MBTPS1 MBTPS1 ZBTB10 ZBTB10 EIF2AK3 EIF2AK3 EXTL1 EXTL1 EIF2S3 EIF2S3 CREB3L1 CREB3L1 CREB3L4 CREB3L4 PDIA5 PDIA5 CEBPG CEBPG EXOSC8 EXOSC8 DIS3 DIS3 ENSMFAP00000008565 ENSMFAP00000008565 EXTL2 EXTL2 EXOSC7 EXOSC7 ATF6B ATF6B ZNF652 ZNF652 EXOSC4 EXOSC4 ERN2 ERN2 CREBRF CREBRF ADD1 ADD1 ENSMFAP00000006576 ENSMFAP00000006576 ENSMFAP00000006481 ENSMFAP00000006481 EDEM1 EDEM1 SYVN1 SYVN1 DNAJB9 DNAJB9 HYOU1 HYOU1 EXOSC3 EXOSC3 SEC31A SEC31A EXOSC1 EXOSC1 CTDSPL CTDSPL TATDN3 TATDN3 EXOSC9 EXOSC9 YIF1B YIF1B ACADVL ACADVL CXXC1 CXXC1 XBP1 XBP1 DCTN1 DCTN1 NFYC NFYC CALR CALR NFYB NFYB ENSMFAP00000000347 ENSMFAP00000000347
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
EXOSC2Uncharacterized protein. (293 aa)
MYDGFMyeloid derived growth factor. (190 aa)
ATF4Activating transcription factor 4. (351 aa)
KHSRPKH-type splicing regulatory protein. (650 aa)
ENSMFAP00000045139eIF2B_5 domain-containing protein. (271 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (492 aa)
EXOSC5Exosome component 5. (260 aa)
SSR1Signal sequence receptor subunit 1. (298 aa)
KLHDC3Kelch domain containing 3. (382 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (449 aa)
ENSMFAP00000043889Uncharacterized protein; Belongs to the heat shock protein 70 family. (619 aa)
DNAJB11J domain-containing protein. (358 aa)
FKBP14Peptidylprolyl isomerase. (211 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
LOC102132274Tr-type G domain-containing protein. (430 aa)
PREBWD_REPEATS_REGION domain-containing protein. (419 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (301 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
SRPRBSRP receptor subunit beta. (271 aa)
DCP2Decapping mRNA 2. (420 aa)
ENSMFAP00000041402Uncharacterized protein. (155 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
CEBPBCCAAT/enhancer-binding protein. (314 aa)
CUL7Cullin 7; Belongs to the cullin family. (1780 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
ARFGAP1ADP ribosylation factor GTPase activating protein 1. (414 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
ATF6Activating transcription factor 6. (669 aa)
HDGFHeparin binding growth factor. (256 aa)
ZBTB17Zinc finger and BTB domain containing 17. (807 aa)
ENSMFAP00000037120Tr-type G domain-containing protein. (366 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
MYNNMyoneurin. (610 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa)
TSPYL2Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity). (695 aa)
ENSMFAP00000035793Tr-type G domain-containing protein. (411 aa)
ENSMFAP00000035364Uncharacterized protein. (430 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
GOSR2Uncharacterized protein; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa)
ENSMFAP00000033101WD_REPEATS_REGION domain-containing protein. (386 aa)
CAGE1Cancer-associated gene 1 protein homolog. (840 aa)
ENSMFAP00000032601CBFD_NFYB_HMF domain-containing protein. (287 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit beta. (333 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa)
TATDN1TatD DNase domain containing 1. (321 aa)
ZBTB46Zinc finger and BTB domain containing 46. (588 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (520 aa)
ZBTB47Zinc finger and BTB domain containing 47. (748 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (72 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
EXTL3Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa)
HERPUD2Ubiquitin-like domain-containing protein. (406 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
SHC1SHC adaptor protein 1. (584 aa)
PARNPoly(A)-specific ribonuclease. (628 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
TATDN2Uncharacterized protein. (762 aa)
CTDSP2FCP1 homology domain-containing protein. (277 aa)
TLN1Talin 1. (2556 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ENSMFAP00000021728eIF2B_5 domain-containing protein. (282 aa)
PLA2G4BPhospholipase A2. (781 aa)
EXOSC6Exosome component 6. (272 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
TPP1Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). (563 aa)
ATF3Activating transcription factor 3. (181 aa)
CTDSP1CTD small phosphatase 1. (261 aa)
SRPRASRP receptor subunit alpha. (638 aa)
YIF1AYip1 interacting factor homolog A, membrane trafficking protein. (293 aa)
SERP2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1054 aa)
ZBTB10Zinc finger and BTB domain containing 10. (873 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
EXTL1Exostosin like glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (675 aa)
EIF2S3Tr-type G domain-containing protein. (472 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
CREB3L4Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). (422 aa)
PDIA5Protein disulfide isomerase family A member 5. (519 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
EXOSC8Exosome component 8. (276 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
ENSMFAP00000008565PID domain-containing protein. (467 aa)
EXTL2Exostosin like glycosyltransferase 2. (337 aa)
EXOSC7Exosome component 7. (293 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
ZNF652Zinc finger protein 652. (606 aa)
EXOSC4Exosome component 4. (245 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (767 aa)
CREBRFBZIP domain-containing protein. (642 aa)
ADD1Adducin 1. (768 aa)
ENSMFAP00000006576ECR1_N domain-containing protein. (330 aa)
ENSMFAP00000006481eIF2B_5 domain-containing protein. (287 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (657 aa)
SYVN1Synoviolin 1. (617 aa)
DNAJB9J domain-containing protein. (222 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
EXOSC3Exosome component 3. (275 aa)
SEC31ASEC31 homolog A, COPII coat complex component. (1250 aa)
EXOSC1Exosome component 1. (195 aa)
CTDSPLCTD small phosphatase like. (267 aa)
TATDN3TatD DNase domain containing 3. (274 aa)
EXOSC9Exosome component 9. (456 aa)
YIF1BYip1 interacting factor homolog B, membrane trafficking protein. (315 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons (By similarity); Belongs to the acyl-CoA dehydrogenase family. (677 aa)
CXXC1CXXC finger protein 1. (656 aa)
XBP1BZIP domain-containing protein. (380 aa)
DCTN1CAP-Gly domain-containing protein. (1278 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
CALRCalreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. (417 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
ENSMFAP00000000347CBFD_NFYB_HMF domain-containing protein. (200 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
Server load: low (16%) [HD]