STRINGSTRING
PCSK9 PCSK9 DMP1 DMP1 TMEM132E TMEM132E KLK1 KLK1 MEN1 MEN1 CCN1 CCN1 QSOX2 QSOX2 FSTL3 FSTL3 FSTL1 FSTL1 EVA1C EVA1C APP APP BMP4 BMP4 PAPPA2 PAPPA2 AFP AFP APOL2 APOL2 SERPINA2 SERPINA2 CDH2 CDH2 TMEM132B TMEM132B RRBP1 RRBP1 PEAR1 PEAR1 EVA1A EVA1A ENSMFAP00000012679 ENSMFAP00000012679 RCN1 RCN1 ENSMFAP00000013911 ENSMFAP00000013911 PRSS35 PRSS35 HRC HRC LAMB2 LAMB2 IGF1 IGF1 ENAM ENAM APOA2 APOA2 SERPIND1 SERPIND1 SPARCL1 SPARCL1 PENK PENK TF TF SCG3 SCG3 SERPINC1 SERPINC1 APOL4 APOL4 GNPTG GNPTG F2 F2 FN1 FN1 MBTPS1 MBTPS1 ENSMFAP00000018589 ENSMFAP00000018589 IGFBP7 IGFBP7 MSLNL MSLNL VCAN VCAN ENSMFAP00000019853 ENSMFAP00000019853 RCN3 RCN3 SHISA5 SHISA5 FAM20A FAM20A CALU CALU FRZB FRZB ANO8 ANO8 MMP1 MMP1 SERPINA1 SERPINA1 CST3 CST3 FAM20C FAM20C MEGF10 MEGF10 IGFBP4 IGFBP4 MATN3 MATN3 GAS6 GAS6 GOLM1 GOLM1 MGAT4A MGAT4A MELTF MELTF APLP1 APLP1 P4HB P4HB TIMP1 TIMP1 APOA5 APOA5 PRKCSH PRKCSH ITIH2 ITIH2 ENSMFAP00000039674 ENSMFAP00000039674 KNG1 KNG1 SDC2 SDC2 ENSMFAP00000041402 ENSMFAP00000041402 SFRP4 SFRP4 KLK3 KLK3 EDIL3 EDIL3 QSOX1 QSOX1 IGFBP2 IGFBP2 VGF VGF IGFBP5 IGFBP5 WFS1 WFS1 CHRDL1 CHRDL1 FBN1 FBN1 PDIA6 PDIA6 IL6 IL6 KLK13 KLK13 VWA1 VWA1 FGF23 FGF23 BMP15 BMP15 MAPK1IP1L MAPK1IP1L GPC3 GPC3 LTBP1 LTBP1 SPP2 SPP2 KTN1 KTN1 TMEM132A TMEM132A IGF2 IGF2 FUCA2 FUCA2 CP CP C3 C3 PROC PROC PNPLA2 PNPLA2 FGA FGA IGFALS IGFALS CHRDL2 CHRDL2 LOC102139474 LOC102139474 APOE APOE MEPE MEPE LAMC1 LAMC1 AMTN AMTN LGALS1 LGALS1 HSP90B1 HSP90B1 MMP2 MMP2 TGOLN2 TGOLN2 MXRA8 MXRA8 NUCB1 NUCB1 PDIA2 PDIA2 AHSG AHSG ADAM10 ADAM10 IGFBP1 IGFBP1 PAPPA PAPPA TMEM132C TMEM132C ENSMFAP00000036068 ENSMFAP00000036068 DNAJC3 DNAJC3 APOA1 APOA1 MFGE8 MFGE8 AMBN AMBN NUCB2 NUCB2 SPP1 SPP1 F5 F5 IGFBP6 IGFBP6 APOL1 APOL1 CHGB CHGB ENSMFAP00000000657 ENSMFAP00000000657 APLP2 APLP2 NOTUM NOTUM CSF1 CSF1 MEGF11 MEGF11 APOB APOB BPIFB2 BPIFB2 CTSG CTSG SERPINA10 SERPINA10 STC2 STC2 ALB ALB CKAP4 CKAP4 AMELX AMELX TMEM132D TMEM132D APOLD1 APOLD1 MSLN MSLN IGFBP3 IGFBP3 TNC TNC MIA3 MIA3 FGG FGG LAMB1 LAMB1 APOL6 APOL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK9Proprotein convertase subtilisin/kexin type 9. (811 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (506 aa)
TMEM132ETransmembrane protein 132E. (1074 aa)
KLK1Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. (258 aa)
MEN1Menin 1. (615 aa)
CCN1Cellular communication network factor 1. (381 aa)
QSOX2Sulfhydryl oxidase. (666 aa)
FSTL3Follistatin like 3. (154 aa)
FSTL1Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). (319 aa)
EVA1CEva-1 homolog C. (441 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PAPPA2Pappalysin 2. (1790 aa)
AFPAlpha fetoprotein. (622 aa)
APOL2Uncharacterized protein. (332 aa)
SERPINA2Serpin family A member 2 (gene/pseudogene); Belongs to the serpin family. (419 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
TMEM132BTransmembrane protein 132B. (1078 aa)
RRBP1Ribosome binding protein 1. (1440 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1041 aa)
EVA1AEva-1 homolog A, regulator of programmed cell death. (152 aa)
ENSMFAP00000012679Uncharacterized protein. (157 aa)
RCN1Uncharacterized protein. (331 aa)
ENSMFAP00000013911Galectin. (134 aa)
PRSS35Serine protease 35. (412 aa)
HRCHistidine rich calcium binding protein. (706 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
IGF1Insulin like growth factor 1. (159 aa)
ENAMEnamelin. (1138 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (132 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (499 aa)
SPARCL1SPARC like 1. (661 aa)
PENKProenkephalin. (267 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
SCG3Secretogranin III. (468 aa)
SERPINC1Serpin family C member 1; Belongs to the serpin family. (464 aa)
APOL4Apolipoprotein L4. (345 aa)
GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma. (305 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
FN1Fibronectin 1. (2477 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1054 aa)
ENSMFAP00000018589Cystatin domain-containing protein. (103 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
MSLNLMesothelin like. (747 aa)
VCANVersican. (3398 aa)
ENSMFAP00000019853Uncharacterized protein. (3228 aa)
RCN3Reticulocalbin 3. (300 aa)
SHISA5Shisa family member 5. (238 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (533 aa)
CALUUncharacterized protein. (323 aa)
FRZBFrizzled related protein. (325 aa)
ANO8Anoctamin. (1237 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
SERPINA1Serpin family A member 1; Belongs to the serpin family. (418 aa)
CST3Cystatin C; Belongs to the cystatin family. (146 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (584 aa)
MEGF10Multiple EGF like domains 10. (1137 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
MATN3Matrilin 3. (445 aa)
GAS6Growth arrest specific 6. (657 aa)
GOLM1Golgi membrane protein 1. (405 aa)
MGAT4AAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By sim [...] (535 aa)
MELTFMelanotransferrin. (812 aa)
APLP1A4_EXTRA domain-containing protein. (655 aa)
P4HBProtein disulfide-isomerase. (510 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
APOA5Apolipoprotein A5. (366 aa)
PRKCSHProtein kinase C substrate 80K-H. (534 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain 2. (946 aa)
ENSMFAP00000039674Uncharacterized protein. (397 aa)
KNG1Kininogen 1. (644 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
ENSMFAP00000041402Uncharacterized protein. (155 aa)
SFRP4Secreted frizzled related protein 4. (368 aa)
KLK3Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. (261 aa)
EDIL3EGF like repeats and discoidin domains 3. (480 aa)
QSOX1Sulfhydryl oxidase. (753 aa)
IGFBP2Insulin like growth factor binding protein 2. (302 aa)
VGFVGF nerve growth factor inducible. (615 aa)
IGFBP5Uncharacterized protein. (272 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
CHRDL1Chordin like 1. (458 aa)
FBN1Fibrillin 1. (2871 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (492 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (212 aa)
KLK13Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (277 aa)
VWA1Von Willebrand factor A domain containing 1. (408 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
MAPK1IP1LMAPK-interacting and spindle-stabilizing protein-like; Belongs to the MISS family. (245 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1683 aa)
SPP2Secreted phosphoprotein 2. (211 aa)
KTN1Kinectin 1. (1357 aa)
TMEM132ATransmembrane protein 132A. (1023 aa)
IGF2Insulin like growth factor 2. (183 aa)
FUCA2Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1090 aa)
C3Complement C3. (1663 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (462 aa)
PNPLA2Patatin like phospholipase domain containing 2. (484 aa)
FGAFibrinogen alpha chain. (928 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (605 aa)
CHRDL2Chordin like 2. (452 aa)
LOC102139474Kallikrein related peptidase 2; Belongs to the peptidase S1 family. (223 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
MEPEMatrix extracellular phosphoglycoprotein. (555 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
AMTNAmelotin. (208 aa)
LGALS1Galectin. (135 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
TGOLN2Trans-golgi network protein 2. (417 aa)
MXRA8Matrix remodeling associated 8. (442 aa)
NUCB1Nucleobindin 1. (463 aa)
PDIA2Protein disulfide isomerase family A member 2. (623 aa)
AHSGAlpha 2-HS glycoprotein. (367 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
PAPPAPappalysin 1. (1556 aa)
TMEM132CTransmembrane protein 132C. (1108 aa)
ENSMFAP00000036068Uncharacterized protein. (114 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (267 aa)
MFGE8Milk fat globule-EGF factor 8 protein. (387 aa)
AMBNAmeloblastin. (447 aa)
NUCB2Nucleobindin 2. (420 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2181 aa)
IGFBP6Thyroglobulin type-1 domain-containing protein. (128 aa)
APOL1Apolipoprotein L1. (381 aa)
CHGBChromogranin B. (677 aa)
ENSMFAP00000000657Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (268 aa)
APLP2Amyloid beta precursor like protein 2. (760 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
CSF1Colony stimulating factor 1. (587 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
APOBApolipoprotein B. (4555 aa)
BPIFB2BPI fold containing family B member 2. (458 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
SERPINA10Serpin family A member 10; Belongs to the serpin family. (471 aa)
STC2Stanniocalcin 2. (302 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
CKAP4Cytoskeleton associated protein 4. (506 aa)
AMELXUncharacterized protein. (205 aa)
TMEM132DTransmembrane protein 132D. (1099 aa)
APOLD1Apolipoprotein L domain containing 1. (279 aa)
MSLNMesothelin. (622 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
TNCTenascin C. (2205 aa)
MIA3MIA SH3 domain ER export factor 3. (1907 aa)
FGGFibrinogen gamma chain. (453 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
APOL6Apolipoprotein L6. (437 aa)
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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